Frailty and Vulnerability as Predictors of Chemotherapy Toxicity in Older Adults: A Longitudinal Study in Peru

Runzer-Colmenares, Fernando M.; Urrunaga-Pastor, Diego; Roca-Moscoso, Max Antonio; Noriega, J. De; Rosas-Carrasco, Óscar; Parodi, José F.

doi:10.1007/s12603-020-1504-3

Cited by 12 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study from Peru analysed how frailty and vulnerability can predict chemotherapy toxicity in patients with cancer. 65 The study included 496 older men with cancer, of which 102 had haematological malignancies (55 with multiple myeloma and 47 with leukaemia or lymphoma). Patients with haematological malignancies were shown to have a high rate of chemotherapy toxicity: 83% in those with lymphoma or leukaemia and 82% in those with multiple myeloma.…”

Section: Methods and Time Of Administrationmentioning

confidence: 99%

“…Both frailty (according to the Fried phenotype) and vulnerability (assessed by VES-13 and G8) were independently associated with an increased risk of chemotherapy toxicity. 65 Two other studies 66,67 from Latin America examined the role of a comprehensive geriatric assessment in patients with lymphoma. A study from Mexico analysed the role of frailty for adjusting chemotherapy dosing in 56 older people with diffuse large B-cell lymphoma (median age 70•5 years).…”

Section: Methods and Time Of Administrationmentioning

confidence: 99%

See 1 more Smart Citation

Implementation of geriatric haematology programmes for the treatment of older people with haematological malignancies in low-resource settings

Soto‐Pérez‐de‐Celis

Martínez-Peromingo²,

Chávarri‐Guerra³

et al. 2021

The Lancet Healthy Longevity

View full text Add to dashboard Cite

In 2020, about 600 000 people aged 65 years and older were diagnosed with a haematological malignancy worldwide, and this number will increase to almost 1 million by 2040, with the largest growth taking place in regions with less developed economies. Health-care systems globally are ill-prepared to face this impending increase in the burden of haematological malignancies among older people, and geriatric oncology and haematology are not properly developed in most low-income and middle-income countries, as well as in many community settings in high-income countries. Here, we provide an overview of the status of geriatric haematology in resource-limited settings, with a focus on health-care systems, educational activities, availability of resource-stratified guidelines, development of clinical programmes, and ongoing research initiatives. We also provide recommendations for the future development of geriatric haematology globally, focusing on the creation of educational activities for health-care providers, fostering research initiatives, improving the inclusion of principles of geriatric care into everyday clinical practice, and building strong international and local partnerships among organisations. Health-care systems in LMICs and burden of haematological malignanciesNon-communicable disease burden has been growing during the last five decades and, because of demographic

show abstract

Section: Methods and Time Of Administrationmentioning

confidence: 99%

Section: Methods and Time Of Administrationmentioning

confidence: 99%

Implementation of geriatric haematology programmes for the treatment of older people with haematological malignancies in low-resource settings

Soto‐Pérez‐de‐Celis

Martínez-Peromingo²,

Chávarri‐Guerra³

et al. 2021

The Lancet Healthy Longevity

View full text Add to dashboard Cite

show abstract

“…We performed a secondary data analysis from a prospective cohort study that included military veterans (men aged 60 years and older) with an oncological diagnosis and curative therapeutic indications, evaluated and enrolled in 2013 and followed until 2015, in the Geriatrics service of Centro M edico Naval (CEMENA) "Cirujano Mayor Santiago Tavara", in Callao, Peru. Previous studies have been carried out with this database [24,25,26]. In the initial evaluation, we had 1178 potentially eligible participants, however, we excluded 81 due to dementia, 121 for having a score 23 in the Mini Mental State Examination, 4 due to incomplete data in the medical records, 9 because they will receive treatment without curative intention, 4 due to treatment discontinuation, 6 were lost during follow-up and 31 did not agree to participate in the study.…”

Section: Study Design Population and Samplementioning

confidence: 99%

Gait speed as a predictor of mortality in older men with cancer: A longitudinal study in Peru

Salazar

Barrueto-Deza

Urrunaga-Pastor

et al. 2022

Heliyon

Self Cite

View full text Add to dashboard Cite

Background: Given the increase in incidence and mortality from cancer in recent years in Latin America and Peru, it is necessary to identify frailty older adults at higher risk of disability, hospitalizations and mortality. However, its measure is complex and requires time. For this reason, it has been proposed that frailty can be evaluated by a single measure, as gait speed. We aimed to evaluate the role of gait speed as a predictor of mortality in older men with cancer in Peru. Methods: A prospective cohort study was carried out that included military veterans (aged 60 years and older) with an oncological diagnosis evaluated at the Centro M edico Naval in Peru during the period 2013-2015. Slow gait speed was defined as <0.8 m/s. All-cause mortality was recorded during a 2-year follow-up. Sociodemographic characteristics, medical and personal history, and functional assessment measures were collected. We performed Cox regression analysis to calculate hazard ratios with their respective 95% confidence intervals. Results: 922 older men were analyzed from 2013 to 2015, 56.9% (n ¼ 525) of whom were >70 years of age. 41.3% (n ¼ 381) had slow gait speed with a mortality incidence of 22.9% (n ¼ 211) at the end of follow-up. The most frequent types of cancer in the participants who died were of the lung and airways (26.1%), liver and bile ducts (23.2%), and lymphomas and leukemias (16.6%). In the adjusted Cox regression analysis, we found that slow gait speed was a risk factor for mortality in older men with cancer (adjusted hazard ratio ¼ 1.55; 95% confidence interval: 1.21-2.23). Conclusions: Slow gait speed was associated with an increased risk of mortality in older men with cancer. Gait speed could represent a simple, useful, inexpensive, rapidly applicable marker of frailty for the identification of older men at higher risk of mortality. Gait speed could be useful in low-and middle-income countries, and in rural areas with limited access to health services.

show abstract

“…There was also a good correlation between vulnerability assessed by the Vulnerable Elders Survey-13 (VES-13) or G-8 questionnaire screening tool and radiotoxicity. The same authors conducted another retrospective cohort study to evaluate the association between frailty with the development of chemotherapy toxicity in oncogeri-atric patients [25] and showed that the physical phenotype of Fried showed the strongest association with mortality.…”

Section: Frailty and Cancer Outcomesmentioning

confidence: 99%

Neuropsychiatric Disorders and Frailty in Older Adults over the Spectrum of Cancer: A Narrative Review

Muzyka

Tagliafico

Serafini

et al. 2022

Cancers

View full text Add to dashboard Cite

Background: The interplay between different neuropsychiatric conditions, beyond dementia, in the presence of a diagnosis of cancer in older adults may mediate patients’ fitness and cancer-related outcomes. Here, we aimed to investigate the presence of depression, sleep disturbances, anxiety, attitude, motivation, and support in older adults receiving a diagnosis of cancer and the dimension of frailty in order to understand the magnitude of the problem. Methods: This review provides an update of the state of the art based on references from searches of PubMed between 2000 and June 2021. Results: The evidence obtained underscored the tight association between frailty and unfavorable clinical outcomes in older adults with cancer. Given the intrinsic correlation of neuropsychiatric disorders with frailty in the realm of cancer survivorship, the evidence showed they might have a correlation with unfavorable clinical outcomes, late-life geriatric syndromes and higher degree of frailty. Conclusions: The identification of common vulnerabilities among neuropsychiatric disorders, frailty, and cancer may hold promise to unmask similar shared pathways, potentially intercepting targeted new interventions over the spectrum of cancer with the delivery of better pathways of care for older adults with cancer.

show abstract

Frailty and Vulnerability as Predictors of Chemotherapy Toxicity in Older Adults: A Longitudinal Study in Peru

Cited by 12 publications

References 35 publications

Implementation of geriatric haematology programmes for the treatment of older people with haematological malignancies in low-resource settings

Implementation of geriatric haematology programmes for the treatment of older people with haematological malignancies in low-resource settings

Gait speed as a predictor of mortality in older men with cancer: A longitudinal study in Peru

Neuropsychiatric Disorders and Frailty in Older Adults over the Spectrum of Cancer: A Narrative Review

Contact Info

Product

Resources

About