Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study

Andrews, James S.; Trupin, Laura; Yelin, Edward H.; Hough, Catherine L.; Covinsky, Kenneth E.; Katz, Patricia P.

doi:10.1007/s10067-017-3541-9

Cited by 51 publications

(66 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our RA population, hand grip strength [ 40 , 41 ] and knee extensor strength [ 42 ] were markedly lower than the normative values in the general population. A recent study on frailty and physical function in RA patients [ 43 ] revealed a lower than average hand grip strength and a similar level of knee extensor strength; however, the study population was slightly older, but the percentage of women was similar. Another study [ 44 ] reported similar values for hand grip strength and knee extensor strength in RA patients in remission.…”

Section: Discussionmentioning

confidence: 92%

Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function

Berner

Haider

Grabovac

et al. 2018

International Journal of Rheumatology

View full text Add to dashboard Cite

Objective The aim of the present study was to assess the association between muscle strength, lower extremity function, employment status, and work ability in RA patients. Methods One hundred seropositive RA outpatients of working age were included in this cross-sectional study. Employment status was assessed by interview and work ability by the Work Ability Index-Single Item Scale (WAS). Muscle strength was determined using dynamometer measurement of isometric hand grip and knee extensor strength. Lower extremity function was measured using the short physical performance battery (SPPB). Regression models estimate the association between unemployment, work ability and muscle strength, and lower extremity function, controlling for sociodemographic and disease-related factors. Results Forty-one percent of the RA patients were not gainfully employed, and their median work ability had a good WAS value (7.00 [4.00-7.00]). Patients with better knee extensor strength (OR=1.07, 95% CI [1.02-1.12) and better physical performance (OR=1.71, 95% CI [1.18-2.49]) had a significantly better chance of gainful employment. The odds for hand grip strength remained significant when adjusted for sociodemographic (OR=1.5, 95% CI [1.00-1.09]), but not for disease-specific variables. Better hand grip strength (β=0.25, p=0.039) and better knee extensor strength (β=0.45, p=0.001) as well as better lower extremity function (SPPB) (β=0.51, p<0.001) remained significantly associated with work ability following adjustment for sociodemographic and disease-specific variables. Conclusions The association of employment status and work ability with parameters of physical fitness suggests that improvement in muscle strength and lower extremity function may positively influence work ability and employment in individuals with RA.

show abstract

Section: Discussionmentioning

confidence: 92%

Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function

Berner

Haider

Grabovac

et al. 2018

International Journal of Rheumatology

View full text Add to dashboard Cite

show abstract

“…Multivariable logistic regressions were performed to evaluate the cross-sectional relationship between CVD (any CVD and specific CVDs) and other factors known to be associated with frailty: chronic lung disease[ 25 , 26 ], arthritis[ 25 , 27 , 28 ], cancer[ 29 ], diabetes[ 25 ], urine incontinence[ 30 ], and polypharmacy[ 31 ]. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the frail compared with the non-frail.…”

Section: Methodsmentioning

confidence: 99%

Frailty in Older Adults with Cardiovascular Disease: Cause, Effect or Both?

Kleipool¹,

Hoogendijk²,

Trappenburg³

et al. 2018

Aging and disease

View full text Add to dashboard Cite

Cardiovascular disease (CVD) has been associated with an increased risk of frailty, but the direction of the association remains unclear. This study set out to examine the bidirectional longitudinal association between CVD and frailty over an extended period of time. Data are from 1432 older adults (aged 65-88yrs) of the Longitudinal Aging Study Amsterdam (LASA), who were followed for 17 years. At baseline and follow-up, CVD was assessed through self-report, medication use and medical records, and classified as angina pectoris, myocardial infarction, heart failure (HF), stroke, and peripheral artery disease. Throughout the study, frailty was assessed using Fried’s frailty criteria. Cox regression models showed that patients with HF had an increased frailty risk (HR 2.7; 95%CI: 1.5-5.1) after a median follow-up of 8.4 yrs. This finding was independent of potential confounders (age, sex, several comorbidities). Examinations of the reverse association revealed that frail older adults were not at risk of incident CVD. Of all older adults with CVD, those with HF have an increased risk of frailty and frail older adults do not have an increased risk of CVD. Our findings emphasize the need for cardiac rehabilitation programs evaluating the effect of physical exercise programs in order to prevent frailty and therewith improve quality of life and independence of care in CVD patients.

show abstract

“…There is considerable literature demonstrating that frail older people tend to have poorer general health and function . However, frailty per se is associated with some diseases (such as depression and dementia) but not others, suggesting that the nature of frailty has not yet been completely characterised .…”

Section: Introductionmentioning

confidence: 99%

“…There is considerable literature demonstrating that frail older people tend to have poorer general health and function. [16][17][18][19][20][21] However, frailty per se is associated with some diseases (such as depression and dementia) but not others, suggesting that the nature of frailty has not yet been completely characterised. 22 For example, what aspects of oral health are worse in frail, compared to non-frail, older people and what are the relationships between various general health comorbidities, frailty and oral health?…”

Section: Introductionmentioning

confidence: 99%

Frailty and oral health: Findings from the Concord Health and Ageing in Men Project

et al. 2019

View full text Add to dashboard Cite

Objective To examine whether frailty in older men is associated with poorer oral health and lower levels of dental service utilisation. Background Poor oral health has been associated with some frailty components. Less is known about the link between frailty and oral health outcomes. Methods A cross‐sectional analysis. Data were collected from 601 older men with both frailty status and oral health information. Frailty was defined as meeting three or more of the Cardiovascular Health Study criteria: weight loss, weakness, exhaustion, slowness and low activity. Dental service utilisation (DSU) behaviour was collected from self‐response questionnaires and face‐to‐face interviews. Oral status (number of remaining and functional teeth, periodontal disease, active coronal decayed surface [ACDS] and self‐rated oral health [SROH]) was recorded by two oral health therapists. The association between frailty and oral health behaviour and risk markers was modelled using logistic regression. Results Nineteen per cent of the participants were identified as frail. There were significant associations between frailty and dentition status (odds ratio [OR]: 2.49, 95% confidence interval [CI]: (1.17‐5.30), and frailty and ACDS (OR: 3.01, CI: 1.50‐6.08) but only ACDS remained significant after adjusting for confounders (adjusted OR: 2.46, CI: 1.17‐5.18). There was no association between frailty and DSU and frailty and SROH. Conclusion Frailty was independently associated with the presence of dental caries. However, DSU, SROH and other oral health markers were not significantly associated with frailty after adjusting for confounders. The prevalence of periodontal disease was high regardless of their frailty status.

show abstract

Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study

Cited by 51 publications

References 41 publications

Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function

Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function

Frailty in Older Adults with Cardiovascular Disease: Cause, Effect or Both?

Frailty and oral health: Findings from the Concord Health and Ageing in Men Project

Contact Info

Product

Resources

About