Frailty and Brain-Muscle Correlates in Older People With Type 2 Diabetes: A structural-MRI Explorative Study

Bourdel-Marchasson, I.; Catheline, Gwénaëlle; Regueme, Sophie; Danet-Lamasou, Marie; Barse, Elodie; Ratsimbazafy, F.; Rodríguez‐Mañas, Leocadio; Hood, Kerenza; Sinclair, A.J.

doi:10.1007/s12603-019-1229-3

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…The English reported that elderly men with newly diagnosed diabetes revealed much weaker muscle strength and a higher probability of physical functions impairment than non-diabetic patients [ 58 ]. In the study by Bourdel-Marchasson et al (2019) the sarcopenia symptoms were found more often in patients with frailty syndrome and were connected with a decreased volume of grey matter responsible for locomotor control [ 59 ]. Diabetes also influenced the grip strength in the study by Gundmi et al 2018 [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Adherence to Medication in Older Adults with Type 2 Diabetes Living in Lubuskie Voivodeship in Poland: Association with Frailty Syndrome

Bonikowska

Szwamel

Uchmanowicz

2022

JCM

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Purpose: Diabetic patients aged 65 years or older are more likely to be frail than non-diabetic older adults. Adherence to therapeutic recommendations in the elderly suffering from diabetes and co-existent frailty syndrome may prevent complications such as micro- or macroangiopathy, as well as significantly affect prevention and reversibility of frailty. The study aimed at assessing the impact of frailty syndrome (FS) on the level of adherence to medication in elderly patients with type 2 diabetes (DM2). Patients and Methods: The research was carried out among 175 DM2 patients (87; 49.71% women and 88; 50.29% men) whose average age amounted to 70.25 ± 6.7. Standardized research instruments included Tilburg frailty indicator (TFI) to assess FS and adherence in chronic disease scale questionnaire (ACDS) to measure adherence to medications. Results: The group of 101 (57.71%) patients displayed medium, 39 (22.29%)—low, and 35 (20.00%)—high adherence. As many as 140 of them (80.00%) were diagnosed with frailty syndrome. The median of the average result of TFI was significantly higher in the low adherence group (p ˂ 0.001) (Mdn = 9, Q1–Q3; 7–10 pt.) than in the medium (Mdn = 6, Q1–Q3; 5–9 pt.) or high adherence (Mdn = 6.00, Q1–Q3; 4.5–8 pt.) ones. The independent predictors of the chance to be qualified to the non-adherence group included three indicators: TFI (OR 1.558, 95% CI 1.245–1.95), male gender (OR 2.954, 95% CI 1.044–8.353), and the number of all medications taken daily (each extra pill decreased the chance of being qualified to the non-adherence group by 15.3% (95% CI 0.728–0.954). Conclusion: Frailty syndrome in elderly DM2 patients influenced medical adherence in this group. The low adhesion group had higher overall TFI scores and separately higher scores in the physical and psychological domains compared to the medium and high adhesion groups.

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Section: Discussionmentioning

confidence: 99%

Adherence to Medication in Older Adults with Type 2 Diabetes Living in Lubuskie Voivodeship in Poland: Association with Frailty Syndrome

Bonikowska

Szwamel

Uchmanowicz

2022

JCM

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“…It was proven that sarcopenia characteristics were present with greater frequency in frail compared to prefrail patients. In addition, a correlation was noted between these characteristics and a reduction in grey matter volumes linked with motor control 54 .…”

Section: Mri Characteristics and Capabilities Contributing To High Di...mentioning

confidence: 90%

The assessment of sarcopenia using magnetic resonance imaging

Bisyri¹,

Lambrou²

2022

JRPMS

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frailty, cardiac and pulmonary disease, mental decline, increased risk for falls, fractures and hospitalization. Even though recognizing sarcopenia can be done through a special questionnaire filling in and clinical test performance, imaging plays a determinant role in sarcopenia's diagnosis confirmation by estimating the muscle quality and quantity. There are various imaging methods that can be used for this purpose, such us ultrasonography, dual energy-ray absorptiometry, computed tomography and Magnetic Resonance Imaging (MRI) 5 .The aim of this review is to present the applications of MRI in sarcopenia assessment, by giving prominence to the advantages of this imaging modality, the specific MRIderived surrogate parameters/biomarkers of sarcopenia and the MRI techniques serving that scope.

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“…( 26 ) investigated the amino acid metabolism profile of older adults with diabetes and frailty and discovered that the levels of some characteristic metabolites such as serum 3-methylhistidine were higher. A structural magnetic resonance study found that, in patients with diabetes and frailty, the decreased size of gray matter involved in motor control was linked to decreased muscle size and strength ( 27 ). In addition, metabolites of the intestinal microbiota and peripheral inflammation affected the decomposition and synthesis of muscle proteins through various signal pathways regulated by inflammation and insulin sensitivity, which also indirectly impacted food intake, resulting in decreased protein synthesis and body frailty ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Combined effect of diabetes and frailty on mortality among Chinese older adults: A follow-up study

et al. 2023

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BackgroundFrailty and diabetes are two important health problems associated with aging in older individuals. This paper seeks to analyze the frailty in older adults suffering from diabetes and the combined effect of diabetes and frailty on mortality risk.MethodsThe frailty index (FI) model was employed when evaluating frailty among the older adults based on the baseline data conducted in 2009; and death as outcome variables collected in 2020 were analyzed. The influence of diabetes on age-related changes in frailty in the older adults and resulting mortality rates was analyzed. Cox regression and Kaplan-Meier curves were applied to evaluate the influence on the risk of death and the 11-year survival of the older adults with varying diabetes and frailty statuses.ResultsUltimately, 1,213 older people aged between 60 and 101, with an average age of (74.79 ± 8.58) at baseline, were included in the analysis. By 2020, there had been 447 deaths with mortality at 36.9% (447/1,213); there were 271 cases of diabetes, with a prevalence of 22.3% (271/1,213). The mean FI value for older adults with diabetes was higher than that of those without regardless of age, and the average annual relative growth rate of the FI value for older adults with diabetes was higher than that of those without diabetes (β = 0.039 vs. β = 0.035, t = 8.367, P < 0.001). For all FI value levels, the mortality rate among older adults with diabetes was higher than that of those without. The Cox Regression analysis showed that, compared with those suffering from neither diabetes nor frailty, older adults with both had the higher mortality risk (HR = 1.760. P < 0.001), followed by older adults suffering from frailty alone (HR = 1.594, P = 0.006), and then by older adults suffering from only diabetes (HR = 1.475, P = 0.033). The survival analysis showed that the median survival of those suffering from diabetes and frailty to be the shortest at just 57.23 (95% CI: 54.05 to 60.41) months, lower than the 83.78 (95% CI: 79.33 to 88.23) months in those suffering from frailty alone, and 119.93 (95% CI: 113.84 to 126.02) months in those with only diabetes, and 124.39 (95% CI: 119.76 to 129.02) months in older adults with neither diabetes nor frailty (P < 0.001).ConclusionFrailty is common among older adults suffering from diabetes, and there is an increased risk of poor health outcomes, such as death, among older adults suffering from diabetes and frailty. When diagnosing, treating, and dealing with older adults with diabetes, attention should be paid to screening and assessing frailty in hopes of identifying it early so that appropriate measures of intervention can be taken to avoid or delay the resulting adverse effects.

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Frailty and Brain-Muscle Correlates in Older People With Type 2 Diabetes: A structural-MRI Explorative Study

Cited by 7 publications

References 24 publications

Adherence to Medication in Older Adults with Type 2 Diabetes Living in Lubuskie Voivodeship in Poland: Association with Frailty Syndrome

Adherence to Medication in Older Adults with Type 2 Diabetes Living in Lubuskie Voivodeship in Poland: Association with Frailty Syndrome

The assessment of sarcopenia using magnetic resonance imaging

Combined effect of diabetes and frailty on mortality among Chinese older adults: A follow-up study

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