Frailty, aging, and periodontal disease: Basic biologic considerations

Clark, Daniel; Kotronia, Eftychia; Ramsay, Sheena E

doi:10.1111/prd.12380

Cited by 68 publications

(59 citation statements)

References 158 publications

(374 reference statements)

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“…Another (38), missing teeth (39) and DMFT values (40). Furthermore, age (41) and the socioeconomic factor may also influence some periodontal parameters (42). In the same way, current smoking (33) and diabetes (34) (9,24,43).…”

Section: Discussionmentioning

confidence: 98%

Primary dental care treatment in primary Sjögren's syndrome: a possible role in improving salivary flow rate

Martins

Floriano

Leon

et al. 2022

Clinical and Experimental Rheumatology

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ObjectivesPrimary Sjögren's syndrome (pSS) is an inflammatory chronic disorder that mainly affects exocrine glands. Additionally, oral infections can aggravate the glandular dysfunction. However, data on primary dental care (PDC) treatment in pSS are scarce. This study aimed to appraise the impact of PDC on Xerostomia Inventory (XI), unstimulated/stimulated salivary flow rates and salivary cytokine profile in pSS. Methods Fifty-two pSS patients and 52 sex-/age-matched control participants without systemic autoimmune diseases were comprisedin a prospective study. At inclusion, all participants were assessed through a standardized protocol, measurement of salivary pro-inflammatory cytokines, and underwent PDC. Dental procedures included: oral hygiene guidance, restorative treatment of caries, surgical removal of residual roots and impacted or partially erupted teeth, cysts, supra and subgingival periodontal scaling and treatment of soft tissue disorders (removal of lesions and treatment of opportunistic infections).After 3 months, the clinical/laboratorial assessments were repeated. group (13.3±8.2 vs. 8.6±6.2, p=0.002), whereas periodontal parameters were comparable in both groups (p>0.05). After PDC, 26.9% of pSS patients showed reduction of at least 6 points (clinical improvement) in XI, but mean XI remained unchanged (p=0.285). PDC resulted in increase in mean unstimulated (p<0.001) and stimulated (p=0.001) salivary flow rates in pSS, without change in salivary cytokine profile (p≥0.05). Results At inclusion, Decayed, Missing and Filled Teeth (DMFT) index was higher in pSS patients than in control ConclusionPDC promoted improvement in unstimulated and stimulated salivary flow rates in pSS. This novel finding reinforces the recommendation of this strategy for pSS patients. Clinicaltrials.gov (Identifier: NCT03711214).

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Section: Discussionmentioning

confidence: 98%

Primary dental care treatment in primary Sjögren's syndrome: a possible role in improving salivary flow rate

Martins

Floriano

Leon

et al. 2022

Clinical and Experimental Rheumatology

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show abstract

“…gingiva, cementum, periodontal ligament and alveolar bone). 4 Fig. 1 highlights the clinical signs of various stages of periodontal disease, ranging from gingivitis to mild, moderate and severe periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…1 Nevertheless, the implications of oral health on general health were not fully appreciated until a sizeable body of scientific evidence in the last 3 decades pointed towards a strong oral-systemic link. 2,3 In particular, periodontal disease, a highly prevalent chronic inflammatory disease of tooth-supporting structures, 4 has been linked to a wide range of common medical conditions. 5,6 Scientific evidence suggests periodontal disease to be associated with type 2 diabetes mellitus (T2DM), 7 cardiovascular disease 8 and adverse pregnancy outcomes, 9 among others.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease and systemic health: An update for medical practitioners

Kalhan

Wong

Allen

et al. 2022

Ann Acad Med Singap

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Introduction: Chronic periodontal disease is a highly prevalent dental condition affecting tooth-supporting tissues. Scientific evidence is accumulating on links between periodontal disease and various systemic conditions. This narrative review provides a holistic yet succinct overview that would assist medical practitioners to deliver integrated care for better clinical outcomes. Method: Scientific evidence on associations between periodontal disease and systemic conditions was synthesised and critically appraised. Key findings of latest prospective cohort studies, randomised clinical trials, and meta-analysis were closely assessed and compiled. Results: A bidirectional relationship has been established, indicating that diabetes and periodontal disease are closely linked and amplify one another, if not successfully controlled. Existing evidence also supports the associations of periodontal disease with cardiovascular diseases and adverse pregnancy outcomes. Successful treatment of periodontal disease and dental prophylaxis has been shown to improve clinical outcomes in these systemic conditions. Other systemic conditions associated with periodontal disease include respiratory diseases, Alzheimer’s disease, rheumatoid arthritis and chronic kidney disease. Although the underlying mechanisms remain to be fully elucidated, it is generally accepted that the inflammatory burden of chronic periodontal disease has an important systemic impact. Conclusion: Oral-systemic links are multifaceted and complex. While evidence linking periodontal disease with a variety of systemic conditions is still emerging, the nature of the relationship is becoming clearer. The updated understanding of these associations warrants the attention of medical experts and policymakers for a concerted effort to develop a patient-centric, integrated model for the treatment of comorbid dental and medical conditions. Keywords: Cardiovascular diseases, dentistry, diabetes, oral health, periodontal diseases, systemic diseases

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“…On the other, aging is a degenerative process, during which immune response capacity is impaired and resistance against infections deteriorates (immune senescence), leading to the occurrence and progression of age‐related pathologies 94,95 . As an extremely common inflammatory disease and a major health concern in aging population, periodontitis has attracted a myriad of studies that attempted to elucidate the role immune senescence might play in its pathophysiology 96 . By now, mounting evidences indicate that immune senescence is involved in the dysregulation of periodontal homeostasis as well as the development of periodontal disease 20 .…”

Section: Effects Of Immune Cells and Immune Senescence In Periodontitismentioning

confidence: 99%

Immune senescence and periodontitis: From mechanism to therapy

Liu

Dan

Zhou

et al. 2022

Journal of Leukocyte Biology

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Periodontitis is one of the most prevalent infectious inflammatory diseases, characterized by irreversible destruction of the supporting tissues of teeth, which is correlated with a greater risk of multiple systemic diseases, thus regarded as a major health concern. Dysregulation between periodontal microbial community and host immunity is considered to be the leading cause of periodontitis. Comprehensive studies have unveiled the double‐edged role of immune response in the development of periodontitis. Immune senescence, which is described as age‐related alterations in immune system, including a diminished immune response to endogenous and exogenous stimuli, a decline in the efficiency of immune protection, and even failure in immunity build‐up after vaccination, leads to the increased susceptibility to infection. Recently, the intimate relationship between immune senescence and periodontitis has come into focus, especially in the aging population. In this review, both periodontal immunity and immune senescence will be fully introduced, especially their roles in the pathology and progression of periodontitis. Furthermore, novel immunotherapies targeting immune senescence are presented to provide potential targets for research and clinical intervention in the future.

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Frailty, aging, and periodontal disease: Basic biologic considerations

Cited by 68 publications

References 158 publications

Primary dental care treatment in primary Sjögren's syndrome: a possible role in improving salivary flow rate

Primary dental care treatment in primary Sjögren's syndrome: a possible role in improving salivary flow rate

Periodontal disease and systemic health: An update for medical practitioners

Immune senescence and periodontitis: From mechanism to therapy

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