Frailty

Morley, John E.; Haren, Matthew T.; Rolland, Yves; Kim, Moon Jong

doi:10.1016/j.mcna.2006.05.019

Cited by 135 publications

(94 citation statements)

References 89 publications

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“…Fragilidade pode ser considerada quando, sob condições de estresse, um indivíduo tem reduzida sua habilidade para executar importantes práticas de atividades instrumentais de vida diária (AIVD) 13 . Isso representa uma forma de pré-incapacidade e, como tal, precisa ser distinto da redução de capacidade funcional.…”

Section: Fragilidade Como Conceitounclassified

“…O conhecimento sobre os eventos que resultam nesta condição é limitado e alguns pesquisadores vêm buscando de forma intensa a identificação da etiologia e as características dessa síndrome [7][8][9][10][11]13 . 15, as pesquisas são realizadas por diferentes especialistas, subdivididas em 11 domínios: 1) história, conceitos e definições; 2) bases biológicas; 3) serviços de saúde; 4) bases sociais; 5) prevalência; 6) história natural e fatores de risco; 7) impacto da fragilidade; 8) identificação; 9) prevenção e conduta terapêutica; 10) ambiente e tecnologia; 11) política social e de saúde.…”

Section: Fragilidade Como Conceitounclassified

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Síndrome da fragilidade no idoso: importância da fisioterapia

Macedo

Gazzola

Najas

2008

Arq. Bras. Ciên. Saúde

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ResumoA fragilidade é conceituada como uma síndrome clínica, que pode ser identificada por perda de peso involuntária, exaustão, fraqueza, diminuição da velocidade da marcha e do equilíbrio e diminuição da atividade física. Cada uma dessas manifestações clínicas é preditora de uma série de reações adversas (quedas, hospitalização, institucionalização, declínio funcional e morte). O objetivo desta revisão de literatura foi expor os elementos sobre a Síndrome da Fragilidade dos Idosos, em uma revisão narrativa da literatura, dando um panorama geral sobre epidemiologia, tendências atuais, ciclo da fragilidade, sarcopenia, alterações imunológicas, alterações neuroendócrinas, diagnósticos clínico, laboratorial e diferencial e as possibilidades de intervenções fisioterapêuticas. Para esses fins, realizou-se revisão bibliográfica da literatura nacional e internacional sobre o tema. Com o conhecimento de estudos envolvendo idosos frágeis, é possível planejar as estratégias voltadas para a identificação da parcela da população que mais se beneficiaria de ações para postergar, atenuar e, se possível, reverter tais desfechos.Palavras-chave: Idoso; fragilidade; envelhecimento; sarcopenia; exercício físico. AbstractThe frailty syndrome is a clinical syndrome that may be identified by involuntary loss of weight, exhaustion, weakness, decrease of walking rate and balance, and decrease of physical activity. Each one of these clinical manifestations predicts a series of adverse reactions (falls, hospitalization, institutionalization, functional decline, and death). The aim of this literature review was to expose the elements on Frailty Syndrome in the elderly in a narrative literature review, providing a general panorama upon epidemiology, actual trends, frailty cycle, sarcopenia, immunological disorders, neuroendocrinal disorders, clinical, laboratorial and differential diagnosis, and the possibilities of physiotherapeutic intervention. Therefore, a national and international literature review on the subject was performed. By knowing studies involving fragile elderly patients, it is possible to plan strategies towards the identification of parcel of the population that would benefit the most from actions to delay, to attenuate and, if possible, to revert such manifestations.

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Section: Fragilidade Como Conceitounclassified

Síndrome da fragilidade no idoso: importância da fisioterapia

Macedo

Gazzola

Najas

2008

Arq. Bras. Ciên. Saúde

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“…[1][2][3][4][5] Multiple instruments to operationalize a definition of frailty have been developed and validated. 1 One index, proposed by Fried, defines frailty as the presence of three or more of five criteria: unintentional weight loss, exhaustion, weakness, slow walking speed, and low physical activity.…”

Section: Introductionmentioning

confidence: 99%

“…4 Using these criteria, estimates of the prevalence of frailty among independently living adults vary from 7 % of persons older than 65 years to 40 % of persons older than 80 years; prevalence estimates are higher among persons with chronic disease. [2][3][4]6 Frailty, using this definition, is associated with increased risk of falls, hospitalization, disability and death. 4 However, diagnosing frailty in the clinical setting can be cumbersome, because most indices of frailty require a combination of anthropometry and physical function testing.…”

Section: Introductionmentioning

confidence: 99%

Phase Angle, Frailty and Mortality in Older Adults

Wilhelm-Leen

Hall²,

Horwitz

et al. 2013

J GEN INTERN MED

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BACKGROUND: Frailty is a multidimensional phenotype that describes declining physical function and a vulnerability to adverse outcomes in the setting of physical stress such as illness or hospitalization. Phase angle is a composite measure of tissue resistance and reactance measured via bioelectrical impedance analysis (BIA). Whether phase angle is associated with frailty and mortality in the general population is unknown. OBJECTIVE: To evaluate associations among phase angle, frailty and mortality. DESIGN: Population-based survey. SETTING: Third National Health and Nutritional Examination Survey (1988)(1989)(1990)(1991)(1992)(1993)(1994). PARTICIPANTS: In all, 4,667 persons aged 60 and older. MEASUREMENTS: Frailty was defined according to a set of criteria derived from a definition previously described and validated. RESULTS: Narrow phase angle (the lowest quintile) was associated with a four-fold higher odds of frailty among women and a three-fold higher odds of frailty among men, adjusted for age, sex, race-ethnicity and comorbidity. Over a 12-year follow-up period, the adjusted relative hazard for mortality associated with narrow phase angle was 2.4 (95 % confidence interval [95 % CI] 1.8 to 3.1) in women and 2.2 (95 % CI 1.7 to 2.9) in men. Narrow phase angle was significantly associated with mortality even among participants with little or no comorbidity. LIMITATIONS: Analyses of BIA and frailty were crosssectional; BIA was not measured serially and incident frailty during follow-up was not assessed. Participants examined at home were excluded from analysis because they did not undergo BIA. CONCLUSIONS: Narrow phase angle is associated with frailty and mortality independent of age and comorbidity.

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“…1 Frail individuals have a higher risk of developing disabilities in basic and instrumental activities of daily living, falling, institutionalization, and death. Although different definitions have been proposed, two themes seem to better depict the frailty concept: i) loss of functional reserve in multiple areas/domains; ii) existence at a level close to or past the threshold for failure, with reduced tolerance to common stressors.…”

Section: Metabolic and Nutritional Approach To Older Frail Peoplementioning

confidence: 99%

Metabolic and nutritional approach to older frail people

Volpato

Zuliani

2017

Geriatr Care

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Frailty is a common clinical syndrome in older adults that carries an increased risk for poor health outcomes including falls, incident disability, hospitalization, and mortality. It is characterized by multisystem dysregulations, leading to a loss of dynamic homeostasis, decreased physiologic reserve, and increased vulnerability to stressors. A large body of literature suggests several important multisystem pathophysiologic processes in the pathogenesis of the frailty syndrome, including chronic inflammation and immune activation, insulin resistance and those in musculoskeletal and endocrine systems. Currently, no effective pharmaceutical interventions have been developed for the prevention and treatment of the frailty syndrome. Conversely, epidemiological and intervention studies suggest that adequate nutrition and physical exercise might prevent or postpone the onset of frailty and related clinical manifestations.

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Frailty

Cited by 135 publications

References 89 publications

Síndrome da fragilidade no idoso: importância da fisioterapia

Síndrome da fragilidade no idoso: importância da fisioterapia

Phase Angle, Frailty and Mortality in Older Adults

Metabolic and nutritional approach to older frail people

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