Fragrance material review on tetrahydrolinalool

Lapczynski, A.; Foxenberg, R.J.; Bhatia, S.P.; Letizia, C.S.; Api, A.M.

doi:10.1016/j.fct.2008.06.076

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…[7] Tetrahydrolinalool (THL) is an acyclic monoterpene presenting as a colorless liquid with a pleasant fragrance. [8] This does not exist of effects related to genotoxicity, phototoxicity or photoallergenicity, according to data obtained from experimental tests using in vitro and in vivo models. [9] It is found in aromatic plants and used in cosmetics, soaps, fine fragrances, and shampoos.…”

Section: Introductionmentioning

confidence: 99%

“…[9] It is found in aromatic plants and used in cosmetics, soaps, fine fragrances, and shampoos. [8] Buckwheat (Fagopyrum tataricum L.), for example, has a series of terpenoid compounds, such as THL, which provide a floral and woody odor to the natural product. [10] THL is produced during linalool metabolism through hydrogenation reaction of the endocyclic double bond, and can also be synthesized in the laboratory.…”

Section: Introductionmentioning

confidence: 99%

“…This does not exist of effects related to genotoxicity, phototoxicity or photoallergenicity, according to data obtained from experimental tests using in vitro and in vivo models [9] . It is found in aromatic plants and used in cosmetics, soaps, fine fragrances, and shampoos [8] . Buckwheat (Fagopyrum tataricum L.), for example, has a series of terpenoid compounds, such as THL, which provide a floral and woody odor to the natural product [10] .…”

Section: Introductionmentioning

confidence: 99%

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Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Fonsêca,

da Silva,

Pires

et al. 2024

ChemMedChem

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Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests. The results may be related to GABAergic regulation, which was also suggested in seizure testing induced by 3‐mercapto‐propionic acid. In the strychnine‐induced seizure testing, none of the groups pretreated with THL modulated the parameters indicative of anticonvulsant effect. The electrophysiological results revealed that THL treatment reduces seizures induced by pentylenetetrazole. The in silico molecular docking studies showed that the interaction between THL and a GABAA receptor model formed a stable complex, in comparison to the crystaligraphic structure of diazepam, a structurally related ligand. In conclusion, all the evidences showed that THL presents effective anticonvulsant activity related to the GABAergic pathway, being a candidate for treatment of epileptic syndromes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Fonsêca,

da Silva,

Pires

et al. 2024

ChemMedChem

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“…These compounds were obviously brought into the vehicle cabin by the passengers, and finally contributed with relevant impact to the overall odor in vehicle 1 in the last measurement (at 23 weeks). The identified odorants are typical representatives of natural products and are common fragrance chemicals used in perfumery or essential oils [27][28][29]. Even the mushroom-like smelling 1-octen-3-ol, being a potential derivative of 1-octen-3-one, is commonly found in manifold applications.…”

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confidence: 99%

Smells like new car or rather like an old carriage? ‐ Resolution of the decay behavior of odorants in vehicle cabins during usage

2022

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In recent years, people spend more and more time in vehicles, for commuting, shopping, and other activities. The vehicle interior can therefore be considered to be part of the living environment.Recently, awareness about the air quality in general and especially the air quality in vehicles has increased. 1 As a consequence, research on the topic of indoor emissions in vehicles has gained momentum, and researchers focused, as a first approximation to the problem, on the total volatile organic compound (TVOC) concentration, and on individual volatile organic compounds (VOCs) that are present in high concentrations or have the potential to be harmful to human health. 1,2

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Conveyor-belt drying of Eugenia uniflora L. leaves: Influence of drying conditions on the yield, composition, antioxidant activity and total phenolic content of supercritical CO2 extracts

Canabarro

Ugalde

Mazutti

et al. 2019

Food and Bioproducts Processing

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Fragrance material review on tetrahydrolinalool

Cited by 5 publications

References 3 publications

Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Smells like new car or rather like an old carriage? ‐ Resolution of the decay behavior of odorants in vehicle cabins during usage

Conveyor-belt drying of Eugenia uniflora L. leaves: Influence of drying conditions on the yield, composition, antioxidant activity and total phenolic content of supercritical CO2 extracts

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