Fragrance material review on geraniol

Lapczynski, A.; Bhatia, S.P.; Foxenberg, R.J.; Letizia, C.S.; Api, A.M.

doi:10.1016/j.fct.2008.06.048

Cited by 95 publications

(64 citation statements)

References 36 publications

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“…24) Moreover, geraniol also shows antioxidant and anti-inflammatory activities in the C. martinii essential oil. 33) In the T. vulgaris essential oil, the primary compounds were p-cymene (14.63%) and thymol (21.46%). This correlates with the antioxidant activities of the T. vulgaris essential oil, because essential oils with elevated proportions of thymol and carvacrol exhibit upregulated antioxidant activities.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs

Tsai

Lin

et al. 2011

Bioscience, Biotechnology, and Biochemistry

148

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Section: Resultsmentioning

confidence: 99%

Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs

Tsai

Lin

et al. 2011

Bioscience, Biotechnology, and Biochemistry

148

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“…1) is a natural plant source of alcohol that is widely found in citronella, geranium, vanilla and rose oils. It is widely used as a spice ingredient and in cosmetics, fragrances, shampoos, soaps and other non-cosmetic products, including household and other detergents (9). The global use of geraniol is >1,000 tons per year.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK

Wang

Zhu

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Geraniol is a type of monoterpenoid with a rose scent and a slightly sweet flavor. It is found in the volatile oil of various plants, and has anti-inflammatory and anti-oxidant effects. The present study aimed to investigate the protective effect of geraniol in inhibiting the inflammatory response, oxidative stress and apoptosis in traumatic spinal cord injury (SCI), as well as to analyze the mechanism underlying its effect. Adult male Sprague-Dawley rats were induced to traumatic SCI through a surgical procedure and were defined as the SCI model group. SCI or normal rats were then administered 250 mg/kg/day geraniol for 4 weeks. The Basso, Beattie and Bresnahan (BBB) test and the spinal cord water content were used to analyze the effect of geraniol against traumatic SCI in rats. The inflammatory response, oxidative stress, and caspase-9 and -3 activities were measured using commercial ELISA kits. In addition, the associated mechanism was analyzed, using western blot analysis to determine the protein expression levels of nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK). The results of the present study demonstrated that BBB scores were significantly increased and the spinal cord water content was significantly inhibited in SCI rats after 3 weeks of geraniol treatment. Furthermore, the inflammatory response, oxidative stress, and the caspase-9 and -3 activities were significantly suppressed upon treatment with geraniol. Finally, the mechanism of geraniol against traumatic SCI downregulated the NF-κB and p38 MAPK pathways in SCI rats. Therefore, the protective effect of geraniol is suggested to inhibit the inflammatory response, oxidative stress and apoptosis in traumatic SCI through the modulation of NF-κB and p38 MAPK.

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“…Geraniol is a naturally occurring acyclic monoterpene derived from herb oils (1). Previous in vivo tumor model studies show that geraniol exerted chemotherapeutic or chemosensitizing activity against several types of cancers, including colon, pancreatic, hepatic, and prostate cancer (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells

Jeon

2011

Int J Oncol

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Abstract. Geraniol, an acyclic dietary monoterpene, suppresses prostate cancer growth and enhances docetaxel chemosensitivity in cultured cell or xenograft tumor models. However, the mechanisms of the geraniol action against prostate cancer are largely unknown. In this study, we investigated the cellular and molecular mechanisms of geraniol-induced cell death in PC-3 prostate cancer cells. Among the examined structurally and functionally similar monoterpenes, geraniol potently induced apoptosis and autophagy. Although independent processes, apoptosis and autophagy acted as cooperative partners to elicit geraniol-induced cell death in PC-3 cells. At a molecular level, geraniol inhibited AKT signaling and activated AMPK signaling, resulting in mTOR inhibition. Combined treatment of AKT inhibitor and AMPK activator markedly suppressed cell growth compared to either treatment alone. Our findings provide insight into future investigations that are aimed at elucidating the role of apoptosis and autophagy in prostate cancer therapy and at developing anticancer strategies co-targeting AKT and AMPK.

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Fragrance material review on geraniol

Cited by 95 publications

References 36 publications

Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs

Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs

Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK

Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells

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