Fragmentation of the mitochondrial network in skin in vivo

Mellem, Daniel; Sattler, Martin; Pagel-Wolff, Sonja; Jaspers, Sören; Wenck, Horst; Rübhausen, Michael; Fischer, F.

doi:10.1371/journal.pone.0174469

Cited by 32 publications

(28 citation statements)

References 33 publications

(34 reference statements)

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“…Aymard et al 40 demonstrated a critical role of autophagy and mitophagy in keratinocyte differentiation, which also raises the possibility of mitochondrial fragmentation in aged keratinocytes owing to the increase in ROS levels with aging and elevated mitochondrial fission in response to oxidative stress. Recently, Mellem et al 41 studied the mitochondrial network in young and old human skin for the first time in vivo and found significantly fewer mitochondrial clusters in the keratinocytes. A highly connected physical network of mitochondria in the epidermal cells of the younger compared to the older skin.…”

Section: Chronological Skin Agingmentioning

confidence: 99%

Mitochondria in skin health, aging, and disease

2020

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The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven by a series of protein complexes collectively known as the electron transport chain (ETC) that is located on the inner membrane of the mitochondria. However, reactive oxygen species (ROS) like superoxide, singlet oxygen, peroxides are inevitably produced during respiration and disrupt macromolecular and cellular structures if not quenched by the antioxidant system. The oxidative damage caused by mitochondrial ROS production has been Is mitochondrial dysfunction a primary or a secondary cause of skin aging? • Does targeting mitochondria prevent or slow down skin aging?

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Section: Chronological Skin Agingmentioning

confidence: 99%

Mitochondria in skin health, aging, and disease

2020

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“…Most skin models used for research were developed from understanding collagen and its role in skin aging. However, skin aging is a more complex and dynamic process of changes in the biophysical network structures . Additionally, the absence of suitable substrates to create a microenvironment that has the correct ratio of elastic and viscoelastic components in tissues may result in errors…”

Section: Discussionmentioning

confidence: 99%

“…However, skin aging is a more complex and dynamic process of changes in the biophysical network structures. 34 Additionally, the absence of suitable substrates to create a microenvironment that has the correct ratio of elastic and viscoelastic components in tissues may result in errors. 1,6 F I G U R E 2 Fluorescent makeup methodology used to measure the cleansing efficacy the sonic brush.…”

Section: Discussionmentioning

confidence: 99%

Facial cleansing with a sonic brush—A review of the literature and current recommendations

Gold

Ablon

Andriessen

et al. 2019

J of Cosmetic Dermatology

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Summary Introduction Skin cleansing is important for removal of dirt, debris, and sebum and plays an important role in reduction of pollution‐induced skin aging. Cleansing is an established part of treatment recommendations and procedures in dermatology. Different methods for facial skin cleansing are established but recommendations on use of special devices are not fully integrated into clinical practice. Aim We review the current literature on sonic cleansing to demonstrate that a gentle and effective cleansing routine using a sonic brush followed by appropriate additional methods for rehydration and skin protection may improve both inflammatory conditions including acne vulgaris and skin damage associated with overexposure to exogenous light and pollution. Methods A working group of experienced clinicians managing facial inflammatory skin conditions convened for a meeting. The panel reviewed the literature surrounding sonic brush cleansing and discussed clinical questions aiming to optimize facial cleansing outcomes. Results The panel agreed there are increasing concerns over the rise of atmospheric pollution globally and its impact on health and skin aging and that cleansing in combination with nonspecific skin care is able to support physiological microenvironmental skin conditions including pH levels on the skin surface, barrier function, and hydration. Conclusion Cleansing poses a challenge in balancing debris removal while avoiding excess sebum removal, thereby maintaining an intact stratum corneum barrier. The sonic brush may offer a safe and effective treatment for various conditions.

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“…With regard to human tissue, aged human retinal pigment epithelium showed significant reductions in the number and area of mitochondria, as well as loss of cristae and matrix density [58]. A study on human skin in vivo showed a significantly more fragmented network with smaller mitochondrial clusters in keratinocytes in old skin compared to keratinocytes in young skin [62].…”

Section: Structural Changes In Mitochondriamentioning

confidence: 99%

Age-Related Deterioration of Mitochondrial Function in the Intestine

Schneider

Özsoy

Zimmermann

et al. 2020

Oxidative Medicine and Cellular Longevity

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Aging is an important and inevitable biological process in human life, associated with the onset of chronic disease and death. The mechanisms behind aging remain unclear. However, changes in mitochondrial function and structure, including reduced activity of the mitochondrial respiratory chain and increased production of reactive oxygen species—thus oxidative damage—are believed to play a major role. Mitochondria are the main source of cellular energy, producing adenosine triphosphate (ATP) via oxidative phosphorylation. Accumulation of damaged cellular components reduces a body’s capacity to preserve tissue homeostasis and affects biological aging and all age-related chronic conditions. This includes the onset and progression of classic degenerative diseases such as cardiovascular disease, kidney failure, neurodegenerative diseases, and cancer. Clinical manifestations of intestinal disorders, such as mucosal barrier dysfunction, intestinal dysmotility, and chronic obstipation, are highly prevalent in the elderly population and have been shown to be associated with an age-dependent decline of mitochondrial function. This review summarizes our current understanding of the role of mitochondrial dysfunction in intestinal aging.

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Fragmentation of the mitochondrial network in skin in vivo

Cited by 32 publications

References 33 publications

Mitochondria in skin health, aging, and disease

Mitochondria in skin health, aging, and disease

Facial cleansing with a sonic brush—A review of the literature and current recommendations

Age-Related Deterioration of Mitochondrial Function in the Intestine

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