Fragmentation of some 4H-pyran-4-one and pyridin-4-one derivatives under electron impact

Structure and Neuroprotector Properties of a Complex Compound of Lithium with Comenic Acid

“…Mass numbers 28 and 44 corresponded to the release of decomposition products, CO and CO 2 , while mass number 112 probably corresponded to the decarboxylation product of the ligand molecule, 3-hydroxy-4H-pyrone. At the same time, taking into account the data from works [ 21 ] regarding the thermal degradation of comenic acid, the formation of an unstable fragment O=C(CO)CH=CH–C=OH + with the same mass number cannot be ruled out. The intensity of the peak with a mass number of 112 was approximately 0.6 × 10 −9 A, which is more than 10 times less than the value for carbon dioxide (12 × 10 −9 A).…”

“…Comenic acid also broke down into smaller fragments (with a mass less than 112), the peak intensities of which gradually increased with increasing sample temperature (m = 57, 91 and 105). As shown earlier [ 21 ], it is difficult to unambiguously determine the degradation products of comenic acid, since a large number of variations that are formed during the degradation of fragments are possible. However, in all cases, the degradation process includes the opening of the pyran ring.…”

“…This effect is expressed as a decrease in the level of neuron death and a decrease in the number of calcium ions in the cytosol [ 18 ]. In addition to these properties, it has a neurotrophic effect; prevents the disruption of synaptic plasticity of hippocampal neurons under stress; and has antioxidant, moderately anti-amnestic and anxiolytic effects [ 7 , 19 , 20 , 21 ].…”