Fragmentation of extracellular DNA by long-term exposure to radiation from uranium in aquatic environments

Arruda‐Neto, J. D. T.; Nieto, L.; Righi, Henriette; Cotta, M. A.; Carrer, Helaine; Rodrigues, T. E.; Genofre, Godofredo C.

doi:10.1039/c2em30196b

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…All uranium isotopes are radioactive and emit alpha particles, which are capable of inducing DNA damage (). Early investigations of somatic cell gene mutation in the FCC did not reveal a relationship between mutations and proximity to the FMPC ().…”

Section: Discussionmentioning

confidence: 99%

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Lu-Fritts

Kottyan

James

et al. 2014

Arthritis & Rheumatology

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Objective Explore the hypothesis that cases of SLE will be found more frequently in community members with high prior uranium exposure in the Fernald Community Cohort (FCC). Methods A nested case control study was performed. The FCC is a volunteer population that lived near a uranium ore processing plant in Fernald, Ohio, USA during plant operation and members were monitored for 18 years. Uranium plant workers were excluded. SLE cases were identified using American College of Rheumatology classification criteria, laboratory testing, and medical record review. Each case was matched to four age-, race-, and sex-matched controls. Sera from potential cases and controls were screened for autoantibodies. Cumulative uranium particulate exposure was calculated using a dosimetry model. Logistic regression with covariates was used to calculate odds ratios (OR) with 95% confidence intervals (CI). Results The FCC includes 4,187 individuals with background uranium exposure, 1,273 with moderate exposure, and 2,756 with higher exposure. SLE was confirmed in 23 of 31 individuals with a lupus ICD9 code, and in 2 of 43 other individuals prescribed hydroxychloroquine. The female:male ratio was 5.25:1. Of the 25 SLE cases, 12 were in the higher exposure group. SLE was associated with higher uranium exposure (OR 3.92, 95% CI 1.131-13.588, p = 0.031). Conclusion High uranium exposure is associated with SLE relative to matched controls in this sample of uranium exposed individuals. Potential explanations for this relationship include possible autoimmune or estrogen effects of uranium, somatic mutation, epigenetic effects, or effects of some other unidentified accompanying exposure.

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Section: Discussionmentioning

confidence: 99%

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Lu-Fritts

Kottyan

James

et al. 2014

Arthritis & Rheumatology

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“…The only abiotic degradation pathway that has been demonstrated to date is the breaking of DNA double strands induced by radiation from dissolved uranium. [43] Sedimentation appears to be an important pathway for the loss of dissolved DNA from the water column. [29] As seston ages there is a relative increase in phosphodiesters [44] much of which is DNA.…”

Section: Quantificationmentioning

confidence: 99%

Organic phosphorus in the aquatic environment

Baldwin¹

2013

Environ. Chem.

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Environmental context. Organic phosphorus can be one of the major fractions of phosphorus in many aquatic ecosystems. This paper discusses the distribution, cycling and ecological significance of five major classes of organic P in the aquatic environment and discusses several principles to guide organic P research into the future.Abstract. Organic phosphorus can be one of the major fractions of phosphorus in many aquatic ecosystems. Unfortunately, in many studies the 'organic' P fraction is operationally defined. However, there are an increasing number of studies where the organic P species have been structurally characterised -in part because of the adoption of 31 P NMR spectroscopic techniques. There are five classes of organic P species that have been specifically identified in the aquatic environment -nucleic acids, other nucleotides, inositol phosphates, phospholipids and phosphonates. This paper explores the identification, quantification, biogeochemical cycling and ecological significance of these organic P compounds. Based on this analysis, the paper then identifies a number of principles which could guide the research of organic P into the future. There is an ongoing need to develop methods for quickly and accurately identifying and quantifying organic P species in the environment. The types of ecosystems in which organic P dynamics are studied needs to be expanded; flowing waters, floodplains and small wetlands are currently all under-represented in the literature. While enzymatic hydrolysis is an important transformation pathway for the breakdown of organic P, more effort needs to be directed towards studying other potential transformation pathways. Similarly effort should be directed to estimating the rates of transformations, not simply reporting on the concentrations. And finally, further work is needed in elucidating other roles of organic P in the environment other than simply a source of P to aquatic organisms.

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Polyaniline/oxidation etching graphitic carbon nitride composites for U(VI) removal from aqueous solutions

Liu

Chen

et al. 2019

J Radioanal Nucl Chem

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Fragmentation of extracellular DNA by long-term exposure to radiation from uranium in aquatic environments

Cited by 6 publications

References 22 publications

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Organic phosphorus in the aquatic environment

Polyaniline/oxidation etching graphitic carbon nitride composites for U(VI) removal from aqueous solutions

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