Fragility and Extractable Collagen in the Lathyritic Chick Embryo. An Assay for Lathyrogenic Agents.

Gross, Jerome; Levene, C. I.; Orloff, Serge; Waksman, Byron H.

doi:10.3181/00379727-105-26040

Cited by 43 publications

(22 citation statements)

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“…Extractibility is high in the skin of actively growing animals [22] ; it diminishes with aging in the human skin [20,23]. It is largely increased in animals treated with an inhibitor of lysyl oxidase, the enzyme involved in the formation of the covalent aldehyde cross-links in the mature fibrils of collagen [24]. The main characteristic of the fascias from the direct hernia was a significant increase in collagen extractibility with pepsin, when compared to the control fascias (5.2 versus 2.6%).…”

Section: Discussionmentioning

confidence: 99%

Biochemical Study of Collagen in Adult Groin Hernias

Pans¹,

Albert²,

Lapière³

et al. 2001

Journal of Surgical Research

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Background. Previous works have suggested that a defect in collagen fiber structure may play a role in inguinal hernia formation. These studies focused mainly on the rectus sheath or the skin, while only few reports dealt with the transversalis fascia. According to these findings and to our previous biomechanical and histological studies suggesting that a connective tissue pathology could play a role in the genesis of groin hernias, we performed a biochemical investigation of the collagen in the transversalis fascia and rectus sheath.

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Section: Discussionmentioning

confidence: 99%

Biochemical Study of Collagen in Adult Groin Hernias

Pans¹,

Albert²,

Lapière³

et al. 2001

Journal of Surgical Research

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“…The toxin BAPN exerts its influence mainly on collagen and elastin metabolism of the connective tissue of the animal system (O'Dell et aZ.,1966;Siege1 et al, 1970). As a consequence, the skin, bone, aorta and blood vessels undergo extensive abnormalities characterized by increased fragility and elasticity of the affected tissues (Lalich et aZ., 1957; Levene and Gross, 1959;Gross et al, 1960;Gristwood, personal communication). The influence of lathyrogens on the protein system of shell membranes is consistent with the general mode of their action on animal systems.…”

Section: Influence Of Lathyrogensmentioning

confidence: 99%

Shell membrane protein system in relation to lathyrogen toxicity and copper deficiency

Chowdhury

1990

World's Poultry Science Journal

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A chronological account of observations on the nature of the shell membrane protein system is presented. The review indicates that although the major protein in the shell membrane is not elastin, it does contain desmosine and isodesmosinethe cross-linking amino acids. The membranes also contain small amounts of collagen. The formation of these proteins can be impaired by the inclusion of lathyrogens in the diet of laying hens. This impairment is caused by a failure to synthesize cross-links of membrane protein and this is very similar to the effect obtained when hens are fed copper-deficient diets. The disruption of the protein system has a considerable effect on the development of eggs, which are abnormal in size, shape and shell texture. The lathyrogens also have a depressing effect on egg production. The problems and prospects of utilizing seeds of certain Lathyrus plants containing lathyrogens are indicated.

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“…Another approach is suggested by the reports of scoliosis and dissecting aneurysms in young rats fed lathyrus odoratus (Ponseti and Baird, 1952;McKay, Lalich, Schilling, and Strong, 1954) and by the similar effects of some derivatives on the chick embryo (Gross, Levene, and Orloff, 1960;Levene, 1958Levene, , 1961. The experiments of Levene and Gross (1959) indicated an alteration in the molecular aggregation of collagen when ,-aminopropionitrile was administered to chick embryos.…”

Section: Thrombosismentioning

confidence: 99%

Pathological findings in homocystinuria

Gibson¹,

Carson²,

Neill³

1964

J Clin Pathol

207

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Pathological findings are described in four cases of a new aminoaciduria in which homocystine is excreted in the urine. All the patients were mentally retarded children. Three of them presented diagnostic features of Marfan's syndrome. Necropsy on one case and biopsy findings in the others are described. Fatty change occurs in the liver. The most striking lesions are vascular. Metachromatic medial degeneration of the aorta and of the elastic arteries in the necropsied case are considered in relation to Marfan's syndrome. Other changes, particularly thrombosis which is prevalent in homocystinuria, suggest the possibility of a platelet defect. The findings are discussed in respect of an upset in the metabolism of sulphur-containing amino-acids and with particular reference to Marfan's syndrome.

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Fragility and Extractable Collagen in the Lathyritic Chick Embryo. An Assay for Lathyrogenic Agents.

Cited by 43 publications

References 0 publications

Biochemical Study of Collagen in Adult Groin Hernias

Biochemical Study of Collagen in Adult Groin Hernias

Shell membrane protein system in relation to lathyrogen toxicity and copper deficiency

Pathological findings in homocystinuria

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