Fractures in Jamaican Males with Prostate Cancer: A Retrospective Case Series

Abstract

Objective: Androgen deprivation therapy (ADT) reduces bone mineral density in men treated for prostate cancer. We sought to determine if there was an ethnic difference in fractures induced by ADT in Jamaican men. Methods: A retrospective analysis of orthopedic admissions to the University Hospital of the West Indies from 2000-2009 was done. Eligible patients had a history of prostate cancer and ADT. Etiology of fractures was determined. Methods of treatment of prostate cancer and clinicopathological data were extracted from medical records.Results: There were 13 admissions for fractures during the period and all were due to metastases. The mean duration of ADT use was 16.4 ± 19.0 (Range: 1-72) months. Conjugated estrogens were the most frequently used method of ADT however 55% of patients were exposed to multiple types of ADT. Conclusion:Fractures in Jamaican men with prostate cancer are rare and associated with metastatic disease.