Oxide dispersion-strengthened (ODS) and molybdenum-0.5 pct titanium-0.1 pct zirconium (TZM) molybdenum have excellent creep resistance and strength at high temperatures in inert atmospheres. Fracture toughness and tensile testing was performed at temperatures between Ϫ150 ЊC and 450 ЊC to characterize 6.35-mm-thick plate material of ODS and TZM molybdenum. A transition from low fracture-toughness values (5.8 to 29.6 MPaΊm) to values Ͼ30 MPaΊm is observed for TZM molybdenum in the longitudinal orientation at 100 ЊC and in the transverse orientation at 150 ЊC. These results are consistent with data reported in literature for molybdenum. A transition to low fracture-toughness values (Ͻ30 MPaΊm) was not observed for longitudinal ODS molybdenum at temperatures ՆϪ150 ЊC, while a transition to low fracture-toughness values (12.6 to 25.4 MPaΊm) was observed for the transverse orientation at room temperature. The fine spacing of La-oxide precipitates which are present in ODS molybdenum results in a transition temperature that is significantly lower than any molybdenum alloy reported to date, with upper-bound fracture-toughness values that bound the literature data. A comparison of fracture-toughness values obtained using 1T, 0.5T, and 0.25T three-point bend specimens shows that a 0.5T bend specimen could be used as a subsized geometry.