Fracture risks in patients with atopic dermatitis

Lin, Teng-Li; Wu, Chunying; Yen, Jeffrey J-Y; Juan, Chao-Kuei; Chang, Yi-Ling; Ho, H.P.; Chen, Yi–Ju

doi:10.1016/j.anai.2021.09.004

Cited by 10 publications

(7 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Systemic treatment of AD impaired the risk of fracture and indicated that While disease-modifying antirheumatic medications (HR = 0.71; 95% CI = 0.53–0.90) and phototherapy (HR = 0.73; 95% CI = 0.56–0.95) treatment decreased the risk of fractures, severe AD was linked to a higher risk of fractures (HR = 1.31, 95% CI = 1.08–1.59) [ 63 ].…”

Section: Osteoporosismentioning

confidence: 99%

Involvement of Atopic Dermatitis in the Development of Systemic Inflammatory Diseases

Itamura

Sawada

2022

IJMS

View full text Add to dashboard Cite

The skin is recognized as a peripheral lymphoid organ that plays an essential defensive action against external environmental stimuli. However, continuous stimulation of these factors causes chronic inflammation at the local site and occasionally causes tissue damage. Chronic inflammation is recognized as a trigger for systemic organ inflammation. Atopic dermatitis (AD) is a chronic inflammatory skin disease that is influenced by various external environmental factors, such as dry conditions, chemical exposure, and microorganisms. The pathogenesis of AD involves various Th2 and proinflammatory cytokines. Recently updated studies have shown that atopic skin-derived cytokines influence systemic organ function and oncogenesis. In this review, we focus on AD’s influence on the development of systemic inflammatory diseases and malignancies.

show abstract

Section: Osteoporosismentioning

confidence: 99%

Involvement of Atopic Dermatitis in the Development of Systemic Inflammatory Diseases

Itamura

Sawada

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…118 Elderly patients with AD, especially those with longer disease duration, lower vitamin D levels, and systemic inflammation, face higher osteoporosis and fracture risks, recognized by the American Academy of Dermatology. 11,[119][120][121][122][123] Hence, appropriate exercises programs, proactive osteoporosis intervention, and education on fall prevention might be considered essential for elderly patients with AD, whose benefits still require further research for substantiation.…”

Section: Ad and Musculoskeletal Agingmentioning

confidence: 99%

Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms

Chen,

Shen,

Cai

et al. 2024

JIR

View full text Add to dashboard Cite

As one of the most prevalent chronic inflammatory skin diseases, atopic dermatitis (AD) increasingly affects the aging population. Amid the ongoing global aging trend, it's essential to recognize the intricate relationship between AD and aging. This paper reviews existing knowledge, summarizing clinical observations of associations between AD and aging-related diseases in various systems, including endocrine, cardiovascular, and neurological. Additionally, it discusses major theories explaining the correlation, encompassing skin-mucosal barriers, systemic inflammation and stress, genes, signal transduction, and environmental and behavioral factors. The association between AD and aging holds significant importance, both in population and basic perspectives. While further research is warranted, this paper aims to inspire deeper exploration of inflammation/allergy-aging dynamics and the timely management of elderly patients with AD.

show abstract

“…The study endpoint was when the study participants were diagnosed with atopic dermatitis. To improve the validity of atopic dermatitis diagnosis, only events consisting of more than three outpatient visits or one inpatient record due to atopic dermatitis were defined as outcome events (14). Each person in the study was followed up from the index date to the date of diagnosis of atopic dermatitis (outcome event), quitting registration from the NHI or on 31 December 2018 (the endpoint of the current study).…”

Section: Study Population Exposure and Outcomesmentioning

confidence: 99%

The association between non-alcoholic fatty liver disease and atopic dermatitis: a population-based cohort study

Gau,

Huang,

Yang

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

BackgroundIn previous studies, it was reported that non-alcoholic fatty liver disease (NAFLD) incidence and prevalence increased in children with atopic dermatitis. Nevertheless, the actual association between the two diseases has not been fully proven in large-scale studies, and real-world evidence is missing. The objective of this nationwide, longitudinal cohort study was to evaluate the association between NAFLD and atopic dermatitis.MethodsThe National Health Insurance Research Database in Taiwan was utilized in this study. Patients with records of NAFLD diagnosis were recruited as the experimental group, and patients having less than three outpatient visits or one inpatient visiting record due to NAFLD were excluded from the study design. Non-NAFLD controls were matched based on a 1:4 propensity score matching. Potential confounders including age, gender, comorbidity, and medical utilization status were considered as covariates. The risk of future atopic dermatitis would be evaluated based on multivariate Cox proportional hazard regression.ResultsCompared with people without NAFLD, a decreased risk of atopic dermatitis in NALFD patients had been observed (aHR = 0.93, 95% CI 0.87–0.98). The trend was especially presented in young NAFLD patients. In patients younger than 40 years old, a 20% decreased risk of atopic dermatitis was reported (aHR = 0.80, 95% CI 0.70–0.92).ConclusionPeople with NAFLD were not associated with an increased risk of atopic dermatitis. Conversely, a 0.93-fold risk was noted in NAFLD patients, compared with NAFLD-free controls. Future studies are warranted to evaluate further the mechanism regarding the interplay between the inflammatory mechanisms of NAFLD and atopic dermatitis.

show abstract

Fracture risks in patients with atopic dermatitis

Cited by 10 publications

References 49 publications

Involvement of Atopic Dermatitis in the Development of Systemic Inflammatory Diseases

Involvement of Atopic Dermatitis in the Development of Systemic Inflammatory Diseases

Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms

The association between non-alcoholic fatty liver disease and atopic dermatitis: a population-based cohort study

Contact Info

Product

Resources

About