Fracture of an ossified Achilles tendon

Brotherton, B. Jason; Jb, Ball

doi:10.1016/0020-1383(79)90019-6

Cited by 16 publications

(6 citation statements)

References 4 publications

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“…The process during which HO forms is governed by MSCs that are attempting to regenerate tissue based on cues from the inflammatory niche. HO can occur in nearly any anatomic site and has been described throughout the musculoskeletal system including ligaments 5 , tendon 6 , periosteum 7 and the fascial or connective tissues surrounding muscles 8 .…”

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confidence: 99%

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

et al. 2020

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Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in response to musculoskeletal trauma, in which mesenchymal stem cells (MSC) differentiate into osteochondrogenic cells instead of myocytes or tenocytes. Despite frequent cases of hospitalized musculoskeletal trauma, the inflammatory responses and cell population dynamics that regulate subsequent wound healing and tissue regeneration are still unclear. Here we examine, using a mouse model of trauma-induced HO, the local microenvironment of the initial post-injury inflammatory response. Single cell transcriptome analyses identify distinct monocyte/macrophage populations at the injury site, with their dynamic changes over time elucidated using trajectory analyses. Mechanistically, transforming growth factor beta-1 (TGFβ1)-producing monocytes/macrophages are associated with HO and aberrant chondrogenic progenitor cell differentiation, while CD47-activating peptides that reduce systemic macrophage TGFβ levels and help ameliorate HO. Our data thus implicate CD47 activation as a therapeutic approach for modulating monocyte/macrophage phenotypes, MSC differentiation and HO formation during wound healing.

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confidence: 99%

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

et al. 2020

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“…Previous reported findings for tendon rupture are soft tissue swelling, loss of soft tissue planes, retraction and interruption of musculotendon tracts, amorphous calcification present in the tendon, and a fracture through an ossified tendon (Brotherton and Ball, 1979;Newberg and Wales, 1977). Only once before has a fracture of an osteophyte of the triceps tendon been reported (Tarnsey, 1972).…”

Section: Discussionmentioning

confidence: 98%

“…This situation frequently is the case in orthopedics, especially with fractures. Radiographic diagnosis of tendon rupture has been made before for the quadraceps, patellar, achilles and triceps tendon (Brotherton and Ball, 1979; Newberg and Wales, 1977;Pantazopoules et a/, 1975;Rucher et al, 1974;Tarsney, 1972). We wish to report two cases of rupture of the triceps tendon; one of the findings has been rarely reported.…”

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confidence: 99%

Ruptured Triceps Tendon Diagnosed Radiographically

Newmark

Halls

1985

Australasian Radiology

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SUMMARY The authors present two cases involving rupture of the triceps tendon that was initially diagnosed on radiographs. Tendon ruptures have been radiographically diagnosed before but only once by a fractured osteophyte of the triceps tendon, to our knowledge. The first case demonstrated this while the other showed an avulsion fracture at the tendon's insertions which has been described previously (seven times) on radiographs.

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“…Only a few cases have been published 4,8,9,10,12,13,14 . The bilateral form and especially with fracture on one side is even more uncommon 1,3,5,6,7,12,15,16,17…”

Section: Discussionmentioning

confidence: 99%

Bilateral Ossification in the Achilles Tendon: A case report

Mády¹,

Vajda²

2000

Foot Ankle Int.

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Bilateral symmetrical Achilles tendon ossification is presented, with a fracture on one side. A 57 year old male patient was conservatively treated for bilateral clubfeet in his childhood. Part of his Achilles tendons were replaced by ectopic bony mass and on the left it fractured without any trauma. The fracture was treated surgically by vertical thinning, intraosseal suture "osteosynthesis", and tendon flap plasty. This pathological condition healed in three months. Seven years after the operation the X-ray revealed total bony rebuilding. The ectopic bone mass has the same biological behaviour as the anatomic bones.

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Fracture of an ossified Achilles tendon

Cited by 16 publications

References 4 publications

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

Ruptured Triceps Tendon Diagnosed Radiographically

Bilateral Ossification in the Achilles Tendon: A case report

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