Fracture Incidence, Quality of Life, and Back Pain during 18-Months Treatment with Teriparatide in Greek Postmenopausal Women with Osteoporosis: Results from the European Forsteo Observational Study

Abstract

Objective. To evaluate fracture incidence, effects on health-related quality of life(QoL), back pain (BP) occurrence and treatment compliance in Greek post-menopausal osteoporotic women treated with teriparatide (TPTD) for up to 18 months, in a naturalistic setting. Methods. 301 patients provided baseline information on demographic characteristics, fracture history, osteoporosis-related medication and risk factors. During treatment, QoL and BP severity were evaluated. Results. Mean (SD) age was 69.5 (±8.5) years. Fracture history was reported by 92.5% of patients. Incidence of fractures (per 10,000 patients/years) ranged from 402 during 0–6 months of treatment, to 346 during 12–18 months. All 5 dimensions of QoL showed improvement. At baseline and 18 months, BP was reported by 93.2% and 64.2% of patients, respectively. BP and limitation of activities were quantified as moderate or severe by 89.9% and 62.3% of patients at baseline versus 32.4% and 14.8% at 18 months. Patients on treatment at 6, 12, 17, and 18 months were 92.6%, 88.3%, 79.6%, and 36.5%, respectively. Conclusions. In the Greek EFOS study cohort, patients prescribed TPTD were severely osteoporotic, with considerable health-related problems. Significant improvements in QoL and BP together with low fracture rates and high compliance have been recorded during treatment.

Adherence to Teriparatide Treatment and Risk of Fracture: A Systematic Review and Meta-Analysis

“…This study shows that the fracture rate decreases with the increase of the time of administration of teriparatide. This is similar to our results [27][28][29][30][31][32][33][34][35][36][37][38][39][40]. There are three systematic reviews and meta-analysis of the impact of anti-osteoporotic drug adherence on prognosis [17][18][19].…”

Quality of Life among Iranian Postmenopausal Women: A Systematic Review and Meta-Analysis

“…Study findings also showed that the total mean score of QOL among 3413 postmenopausal women was 57.89±12.8 (in the possible range of 0-174), indicating good QOL. Several earlier studies in different countries also reported good QOL among postmenopausal women [40][41][42]. However, some studies reported low QOL among menopausal women [14,43,44].…”

Persistance du traitement et évolution du risque de fracture, des douleurs rachidiennes et de la qualité de vie chez les patients traités par du tériparatide en pratique clinique de routine en France : résultats de l’étude observationnelle européenne Forsteo

“…Plus de 95 % des femmes avaient eu deux ou plusieurs fractures vertébrales, en conformité avec le critère de remboursement [11]. Elles souffraient d'ostéoporose plus sévère que les femmes de la cohorte européenne complète [15,19] et de la cohorte grecque [20], sur la base du nombre de fractures antérieures, et avec moins de maladies concomitantes [15,19].…”