Fractionnement Et Mesure Des 17-Cetosteroides Urinaires Neutres Au Cours De La Maladie De Cushing

Baulieu, E E; Veld, L. G. Huis in't; Jaoude, Antoine Abou; Jayle, M F

doi:10.1530/acta.0.0260153

Cited by 5 publications

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“…This elevation of the 5/?/5oc ratio has been observed previously (Pond, 1954;Baulieu, Huis in't Veld, Jaoudé & Jayle, 1957;Jailer et al 1959), and may not be confined to the C-19 steroids, since Bush & Willoughby (1957) also observed a relative increase in the 5/3/5a ratio of the tetrahydro derivatives of cortisol excreted by patients with mild Cushing's syndrome. Jailer et al (1959) were also able to demonstrate this abnormality in the oxosteroids excreted by two patients treated over long periods with ACTH.…”

Section: Discussionsupporting

confidence: 84%

The Excretion of Individual 17-Oxosteroids in Cushing's Syndrome

James¹

1961

Journal of Endocrinology

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The urinary excretion levels of individual 17-oxosteroids in eight patients with Cushing's syndrome have been determined quantitatively. Using these values approximate secretion rates of cortisol and 11\g=b\-hydroxyandrostenedione were calculated and found to be elevated above the normal range. The excretion values for 11-deoxy-17-oxosteroids were highly variable, being below normal, normal or elevated in different patients. The excretion patterns in adrenocortical hyperplasia and carcinoma showed no characteristic differences; however, the patients with adrenal adenoma showed steroid excretions which suggested that these tumours secreted cortisol almost exclusively, together with small quantities of 11\g=b\-hydroxyandrostenedione, and minimal amounts of 11-deoxy-C19-steroids. The majority of patients excreted aetiocholanolone and androsterone in an abnormally high ratio; this also occurred after administration of androst-4-ene-3:17\x=req-\ dione, and it is suggested that in Cushing's syndrome the hepatic enzymes preferentially reduce adrenal androgen to metabolites with the 5\g=b\ configuration.

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Section: Discussionsupporting

confidence: 84%