Fractionation of Heteromorpha arborescens var abyssinica (Apiaceae) leaf extracts based on polarity leads to a marked change in cytotoxicity that may yield a commercially useful product

Adamu, M.; Bagla, Victor Patrick; Eloff, Jacobus Nicolaas

doi:10.1016/j.sajb.2015.08.009

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…These antibacterial activities exhibited by extracts of H. arborescens support the traditional usage of the species as remedy for diseases caused by bacterial pathogens such as boils [40], dysentery [3,6,32,36], gonorrhea [51], skin infections [39], and stomach problems [6,16,46]. [70].These antifungal activities exhibited by H. arborescens extracts validate the traditional use of the species against fungal infections and ringworm in South Africa and Tanzania [33,42].…”

Section: Anthelmintic Activitiesmentioning

confidence: 79%

“…The extracts exhibited moderate toxicity with LC 50 value of 0.04 mg/ml and selectivity index value of 0.07 [69]. Adamu et al [70] evaluated cytotoxicity activities of crude, butanol, ethyl acetate, chloroform, and hexane leaf extracts of H. arborescens using the MTT assay on Vero cells with berberine chloride (Sigma) as a positive control. The EC 50 values exhibited by the extracts ranged from 0.04 mg/ml to 2.1 mg/ml [70].…”

Section: Cytotoxicity Activitiesmentioning

confidence: 99%

“…Adamu et al [70] evaluated cytotoxicity activities of crude, butanol, ethyl acetate, chloroform, and hexane leaf extracts of H. arborescens using the MTT assay on Vero cells with berberine chloride (Sigma) as a positive control. The EC 50 values exhibited by the extracts ranged from 0.04 mg/ml to 2.1 mg/ml [70]. Elisha et al [73] evaluated the cytotoxicity activities of acetone leaf extracts of H. arborescens on Vero kidney cells using the MTT reduction assay with doxorubicin as a positive control.…”

Section: Cytotoxicity Activitiesmentioning

confidence: 99%

“…The activities in the larval development test were generally lower than the egg hatch assay[69]. Adamu et al[70] evaluated the anthelmintic activities of crude, butanol, ethyl acetate, chloroform, and hexane leaf extracts of H. arborescens using the egg hatch assay and the larval development test on the helminth, Haemonchus contortus. The extracts exhibited activities with EC 50 values of 0.6 mg/ml to 2.9 mg/ml for the egg hatch assay and EC 50 values of 0.6 mg/ml to 3.3 mg/ml in the larval development assay[70].…”

mentioning

confidence: 99%

“…Adamu et al[70] evaluated the anthelmintic activities of crude, butanol, ethyl acetate, chloroform, and hexane leaf extracts of H. arborescens using the egg hatch assay and the larval development test on the helminth, Haemonchus contortus. The extracts exhibited activities with EC 50 values of 0.6 mg/ml to 2.9 mg/ml for the egg hatch assay and EC 50 values of 0.6 mg/ml to 3.3 mg/ml in the larval development assay[70]. These anthelmintic activities exhibited by H. arborescens extracts corroborate the traditional usage of leaves and roots of the species against intestinal worms in Lesotho[35], South Africa[3,6,16,30,36], and Swaziland[11].…”

mentioning

confidence: 99%

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Heteromorpha Arborescens: A Review of Its Botany, Medicinal Uses, and Pharmacological Properties

Maroyi

2018

Asian J Pharm Clin Res

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Heteromorpha arborescens is an important medicinal plant species throughout its distributional range in tropical Africa. This study evaluated the botany, medicinal uses, and pharmacological activities of H. arborescens. Literature focusing on the botany, phytochemical, pharmacological, and toxicological properties of H. arborescens were obtained from scientific databases such as SCOPUS, Science Direct, PubMed, SciFinder, Medline, and Google Scholar. Pre-electronic literature sources such as book chapters, books, journal articles, conference papers, and other scientific documents were obtained from the University library. Literature search revealed that H. arborescens is used as an aphrodisiac, as herbal medicine for shortness of breath, intestinal worms, inflammation, pain, respiratory problems, skin infections, headache, fever, and malaria. Pharmacological studies of compounds and H. arborescens extracts revealed anthelmintic, antiarthritic, antibacterial, antifungal, anti-inflammatory, antimycobacterial, antinociceptive, antioxidant, antipeptic ulcer, anti-scabies, antispasmodic, antiviral, cytotoxicity, genotoxicity, and uterotonic activities. More detailed research is needed aimed at assessing phytochemical, pharmacological, and toxicological properties of different plant parts and phytochemical compounds isolated from the species.

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