Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity

Talmadge, James E.; Chavez, Jennifer; Jacobs, Lori; Munger, Corey M.; Chinnah, Tony; Chow, Jimmy T.; Williamson, David A.; Yates, Kenneth M.

doi:10.1016/j.intimp.2004.07.013

Cited by 110 publications

(66 citation statements)

References 52 publications

(79 reference statements)

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“…Aloe leaves contain many physiologically active substances with immunomodulatory, antimicrobial, anti-inflammatory and wound-healing properties, belonging to glycoproteins, anthraquinones, polysaccharides and low-molecular-weight species [1]. Some of these compounds also presented indirect and direct anti-tumor activity [2][3][4][5][6][7]. It was reported in experiments on mice implanted with sarcoma cells that Aloe polysaccharides between 400 and 5 KDa molecular size exhibited the most potent antitumor activity in vivo and in vitro [8].…”

Section: Introductionmentioning

confidence: 99%

Aloe arborescens and American cranberry ( Vaccinium macrocarpon ) extracts inhibit tumor-induced cutaneous angiogenesis in mice

Skopiński¹,

Zdanowski²,

Bałan³

et al. 2013

cejoi

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Section: Introductionmentioning

confidence: 99%

Aloe arborescens and American cranberry ( Vaccinium macrocarpon ) extracts inhibit tumor-induced cutaneous angiogenesis in mice

Skopiński¹,

Zdanowski²,

Bałan³

et al. 2013

cejoi

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“…such as B-complex, C,β-carotene and α-tocopherol (Vinson et al 2005); and other organic compounds, such as triglicerides, triterpenoid, gibberellin, potassium sorbate and salicylic acid (Hamman 2008). AvLE possesses various biological and physiological attributes: healing ability of skin burns and cutaneous injuries, prophylactic effect against radiation leucopenia, anti-ulcer, inhibitory action against some bacteria and fungi, inflammation-inhibiting effect, inhabitation of the prostaglandin synthesis by anthraquinone-type compounds and inhabitation of the AIDS virus by acemannan (Hernandez-Cruz et al 2002, Talmadge et al 2004.…”

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confidence: 99%

The Effects of <i>Aloe vera</i> L. Leaf Extract on Some Physiological and Cytogenetical Parameters in <i>Allium cepa</i> L. Seeds Germinated under Salt Stress

2016

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SummaryThe present study was performed to evaluate the role of Aloe vera L. leaf extract (AvLE) on some physiological and cytogenetical parameters of Allium cepa L. seeds exposed to salinity. The radicle length of the seeds germinated in the medium with AvLE alone increased as compared with ones of the control seeds germinated in distilled water medium, while their radicle number and fresh weight reduced according to the control. In addition, the germination percentage of the mentioned seeds statistically was the same as the control seeds. Furthermore, the seeds germinated in the media containing 0.1 mg/L AvLE alone showed a significant increase of mitotic index, although they exhibited a higher number of chromosomal aberrations and micronucleus (MN) formation as compared with the seeds germinated in control conditions. On the other hand, salt stress considerably inhibited the seed germination and seedling growth of A. cepa. Moreover, salinity markedly decreased the mitotic index in root tip meristems of the seeds and increased the number of chromosomal aberrations. The negative effect of salt on the seed germination, seedling growth, mitotic activity and MN formation was alleviated in dramatically varying degrees by AvLE application. In contrast, the detrimental effects of salt on the chromosomal aberrations greatly increased with this treatment. Consequently, we reported that the application of AvLE alone induced chromosomal aberrations and MN formation, which are an indicator of genotoxicity, and had cytotoxic activity in normal conditions. However, the frequency of MN is greatly reduced in root tip cells of the seeds germinated in the medium containing 0.1 mg/L AvLE +0.15 M NaCl.

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“…This remedy also promotes wounds and ulcers healing, exerts hematopoietic activity and possesses antimicrobial and anti-inflammatory properties (Talmadge et al 2004). Thai authors reported the effects of Aloe vera in rat models of gastric ulcers induced with acetic acid or Helicobacter pylori infection (Eamlammam et al 2006, Prabjone et al 2006.…”

Section: Discussionmentioning

confidence: 99%

In vivo inhibitory effect of Aloe vera gel on the ability of mouse parental splenic lymphocytes to induce cutaneous angiogenesis in recipient F1 mice

Skopiński¹,

Lewicki

Bałan³

et al. 2014

Polish Journal of Veterinary Sciences

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Lymphocyte-induced angiogenesis test (LIA) is a model of local graft-versus-host (GVH) reaction, marker of the earliest events resulting from activation of donor lymphocytes after contact with host semi-allogeneic histocompatibility antigens. The effect of in vivo oral administration of Aloe vera gel for 21 days to maternal strain (Balb/c) donor mice on the ability of their splenic lymphocytes to induce cutaneous angiogenesis (LIA test) in F1 Balb/c x C3H recipients, was studied.Results: Neovascular reaction evaluated 72 hours after cells grafting was significantly lower in F1 mice grafted with lymphocytes collected from Aloe-fed donors, than in recipients of lymphocytes collected from respective controls. Conclusions: This observation opens the promise of safe and ethically acceptable possibility of use of Aloe vera gel in human donors in prevention of GVHD in recipients of bone marrow grafts.

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Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity

Cited by 110 publications

References 52 publications

Aloe arborescens and American cranberry ( Vaccinium macrocarpon ) extracts inhibit tumor-induced cutaneous angiogenesis in mice

Aloe arborescens and American cranberry ( Vaccinium macrocarpon ) extracts inhibit tumor-induced cutaneous angiogenesis in mice

The Effects of <i>Aloe vera</i> L. Leaf Extract on Some Physiological and Cytogenetical Parameters in <i>Allium cepa</i> L. Seeds Germinated under Salt Stress

In vivo inhibitory effect of Aloe vera gel on the ability of mouse parental splenic lymphocytes to induce cutaneous angiogenesis in recipient F1 mice

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