Fractionation of 50kGy electron beam irradiation: Effects on biomechanics of human flexor digitorum superficialis tendons treated with ascorbate

Effects of high-dose gamma irradiation on tensile properties of human cortical bone: Comparison of different radioprotective treatment methods

“…This finding is consistent with those of Hoburg et al (2011);Wei et al (2013), providing additional support for efficiency of the dose fractionation method in preserving the gamma sterilized bone mechanical properties. Furthermore, our results are in line with the previous studies (Kattaya et al, 2008;Miekka et al, 2003) that reported a reduced amount of radiation-induced damages by slower dose rates (in the order of days) of gamma-ray than a rapid one (in the order of hours).…”

“…Therefore, the radioprotective methods such as free radical scavenger treatments as well as fractionation of the E-beam irradiation have been proposed to overcome this limitation (Hoburg et al, 2011;Wei et al, 2013). The rationale behind these methods is the minimization of the possibility of the free radical production that result from radiolysis of the collagen water bonds during exposure to ionizing radiation.…”

“…They used the fractionation of 34 kGy E-beam irradiation (3.4 kGy at 10 fractions) for improving the viscoelastic and structural properties of bone-patellar tendon-bone (BPTB) grafts. Furthermore, Wei et al (2013) showed that splitting the sterilization dose of 50 kGy to 20 equal fractions maintains the native post-yield tensile properties of the human flexor digitorum superficialis tendons.…”

“…(2005) Free radical scavengers: -Improvement of the tensile post yield properties of the 36.4 kGy gamma irradiated human femoral bone (Akkus et al, 2005) -Decreases in the degradation of the tensile properties of the Achilles tendons from the mature rabbits with during gamma doses of 25 and 50 kGy gamma rays(Seto et al, 2012) -Improvement of the microhardness (Allaveisi et al, 2014) as well as compressive mechanical properties (Allaveisi et al, 2015) of the bovine femoral cortical bone irradiated with 18-70 kGy gamma-(Hoburg et al, 2011) and 50 kGy (Wei et al, 2013) E-beam dose fractionation Improving of the viscoelastic (Hoburg et al, 2011) as well as tensile post-yield (Wei et al, 2013) mechanical properties of the irradiated tendons -Not reported Wei et al (2013)Wei et al (2013) Dual treatment by 50 kGy E-beam dose fractionation and ascorbate free radical scavengerReduction of impairments of post-yield tensile properties of the 50 kGy irradiated human flexor digitorum superficialis tendons to the level of non-irradiated specimens Not…”

The effects of irradiation on the biological and biomechanical properties of an acellular porcine superflexor tendon graft for cruciate ligament repair

“…[22][23][24] For products with a very low bioburden a lower dose of 15 kGy (VDMax 15) is acceptable (ISO 11137-2-212), as would be the case for grafts which have undergone PAA treatment. More recently, the use of electron beam (Ebeam) irradiation sterilization has increased, 25,26 and has been shown to have different effects on the tissue biomechanics compared to gamma irradiation. 27 These differences are thought to be a function of the higher dose rate of Ebeam compared to gamma irradiation, reducing the sterilization time and detrimental effects on the tissue.…”