Abstract:Background: The preliminary experiments indicated that a 30% aqueous extract of seeds of the Terminalia chebula has a significant neutralizing activity against tick-borne encephalitis virus (TBEV). In this study, we developed the most gentle approach to purify the antiviral substance. Methods and Results: The extract of T. chebula seeds was fractionated using gel filtration in Sephadex G-200 and G-50. The fractions were tested in vitro for the presence of a direct antiviral action against TBEV and profiled usi… Show more
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