Fractionated stereotactic radiotherapy for the treatment of vestibular schwannomas: combined experience of the Toronto-Sunnybrook Regional Cancer Centre and the Princess Margaret Hospital

Szumacher, Ewa; Schwartz, Michael L.; Tsao, May; Jaywant, S.; Franssen, Edmée; Wong, C. Shun; Ramaseshan, R.; Lightstone, A. W.; Michaels, Howard B.; Hayter, Charles; Laperriere, N.

doi:10.1016/s0360-3016(02)02779-7

Cited by 43 publications

(14 citation statements)

References 26 publications

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“…Serviceable hearing was defined clinically as ''any hearing allowing both use of the telephone on the affected side and intelligible words to be heard.'' 1 Hearing preservation was thus defined as those patients who had baseline serviceable hearing that was retained post-FSRT. The Gardner-Robertson Hearing Class 18 was not retrospectively assigned to patients with both baseline serviceable hearing and audiometric assessments.…”

Section: Methodsmentioning

confidence: 99%

“…These benign tumors are typically characterized by slow growth, but may eventually be associated with significant neurologic symptoms related to compression of both involved and adjacent cranial nerves and the brainstem. 1,2 Ideal treatment for AN should offer a high probability of local control with minimal risks to neural structures. Microsurgery has been the traditional treatment, representing a safe and effective treatment with resultant excellent local control rates ranging from 94% to 99%.…”

mentioning

confidence: 99%

“…Microsurgery has been the traditional treatment, representing a safe and effective treatment with resultant excellent local control rates ranging from 94% to 99%. 3,4 Other treatment options for AN include fractionated stereotactic radiotherapy (FSRT) 1,5,6 and stereotactic radiosurgery-using both linear accelerator (linac) 7 and gamma knife (GK)-based approaches. 8,9 Alternatively, in selected cases a conservative management approach may be a desirable alternative.…”

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confidence: 99%

“…It may therefore be asso-ciated with a lesser risk of cranial nerve toxicity. 1,14 Various series of FSRT outcomes in AN have reported 5-year local control rates ranging from 93% to 98% utilizing a variety of fractionation regimens, 6,14,15 with a recent series of a 20-year experience with FSRT documenting very long-term efficacy. 16 The purpose of this study was to contribute our experience with a linac-based FSRT regimen.…”

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confidence: 99%

“…The current study represents an update of our previously reported experience. 1 Our purpose was to assess the clinical outcome, toxicity, and tolerance of FSRT in patients treated for AN from the inception of the FSRT program for intracranial targets at our institution.…”

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confidence: 99%

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Fractionated stereotactic radiotherapy for acoustic neuroma

Koh

Millar

Ménard

et al. 2007

Cancer

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BACKGROUND.The clinical outcome and toxicity of fractionated stereotactic radiotherapy (FSRT) was assessed for acoustic neuroma in 60 patients treated in a single institution.METHODS.Between October 1996 and February 2005, 60 patients received FSRT for acoustic neuroma (AN). The mean total dose applied was 50 Gy in single daily 2‐Gy fractions over 5 weeks. The median irradiated tumor volume was 4.9 cm3 (range, 0.3–49.0 cm3). The median follow‐up period was 31.9 months.RESULTS.FSRT was well tolerated in all patients. The 5‐year actuarial local control rate was 96.2% (95% CI: 91.1%–100.0%). Five‐year actuarial progression‐free survival was 92.8% (95% CI: 84.8%–100.0%). The overall hearing preservation rate was 77.3%. Five of 6 patients with initial cranial nerve V (CNV) numbness remained stable post‐FSRT. Two of 3 patients with baseline trigeminal neuralgia improved with the remaining patient stable. All 3 patients with nonsurgically related facial nerve weakness either improved or achieved stability in function. There were no cases of new cranial nerve toxicity post‐FSRT.CONCLUSIONS.FSRT for the treatment of AN is safe, effective, and well tolerated. FSRT should thus be considered as an effective alternative treatment modality when compared with microsurgical resection or single fraction stereotactic radiosurgery. Cancer 2007. © 2007 American Cancer Society.

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Fractionated stereotactic radiotherapy for acoustic neuroma

Koh

Millar

Ménard

et al. 2007

Cancer

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Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma

Paek

Chung

Jeong

et al. 2005

Cancer

176

115

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We studied the distributions of interneurons containing the calcium‐binding proteins parvalbumin and calbindin D‐28k, as well as that of pyramidal neurons containing nonphosphorylated neurofilament (NNF), in the middle temporal visual area (MT) of marmoset monkeys. The distributions of these classes of cells in MT are distinct from those found in adjacent areas. Similar to the primary visual area (V1), in MT, calbindin‐immunopositive neurons can be objectively classified into “dark” and “light” subtypes based on optical density of stained cell bodies. Calbindin‐positive dark neurons are particularly concentrated in layers 2 and 3, whereas light neurons have a more widespread distribution. In addition, a subcategory of calbindin‐positive dark neuron, characterized by a “halo” of stained processes surrounding the cell body, is found within and around layer 4 of MT and V1. These cells are rare in most other visual areas. In comparison, parvalbumin‐immunopositive cells in area MT have a relatively homogeneous distribution, although with a trend toward higher spatial density in lower layer 3, and are relatively uniform in terms of density of staining. Finally, MT shows a characteristic trilaminar distribution of NNF‐immunopositive pyramidal cells, with stained cell bodies evident in layers 3, 5, and 6. Although the laminar distribution of cells stained for the three markers overlap to some extent, these subcategories can be readily distinguished in terms of morphology, including cell body size. Chemoarchitectural parallels observed between MT and V1 suggest comparable physiological requirements and neuronal circuitry. J. Comp. Neurol. 500:832–849, 2007. © 2006 Wiley‐Liss, Inc.

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Benign Primary Brain Tumors

Day

Halasz

2017

Controversies in Radiation Oncology

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Fractionated stereotactic radiotherapy for the treatment of vestibular schwannomas: combined experience of the Toronto-Sunnybrook Regional Cancer Centre and the Princess Margaret Hospital

Cited by 43 publications

References 26 publications

Fractionated stereotactic radiotherapy for acoustic neuroma

Fractionated stereotactic radiotherapy for acoustic neuroma

Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma

Benign Primary Brain Tumors

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