Fractionated proton beam irradiation of pituitary adenomas

Ronson, Brian B.; Schulte, R.; Han, Khanh P.; Loredo, Lilia N.; Slater, James M.; Slater, Jerry D.

doi:10.1016/j.ijrobp.2005.07.978

Cited by 84 publications

(31 citation statements)

References 33 publications

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“…The principal theoretical advantage of protons is marginally more localised radiation delivery. Helium and carbon ions also have higher linear energy transfer properties (Bolsi et al 2003;Ronson et al 2006) and theoretically produce a more potent biological effect.…”

Section: Radiotherapy Equipmentmentioning

confidence: 99%

Radiation-induced hypopituitarism

Fernández¹,

Brada²,

Zabuliene³

et al. 2009

Endocrine-Related Cancer

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The hypothalamic-pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, extrasellar brain tumours, head and neck tumours, and following whole body irradiation for systemic malignancies. Increasing tumour-related survival rates provide an expanding population at risk of developing hypopituitarism. In this population, long-term monitoring tailored to the individual risk profile is required to avoid the sequelae of untreated pituitary hormonal deficiencies and resultant decrease in the quality of life. This review analyses the pathogenesis, prevalence and consequences of radiation-induced hypopituitarism (RIH) in diverse subgroups at risk. Also discussed is the impact of modern radiotherapy techniques in the prevalence of RIH, the spectrum of endocrine disorders and radiation-induced brain conditions that also occur in patients with RIH.

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Section: Radiotherapy Equipmentmentioning

confidence: 99%

Radiation-induced hypopituitarism

Fernández¹,

Brada²,

Zabuliene³

et al. 2009

Endocrine-Related Cancer

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“…Data on proton treatment in pituitary adenomas are available both with the option of conventional fractionation [43] or with SRS [44][45][46][47]. In a small series of 22 patients treated with proton SRS for persistent acromegaly at a median follow-up of 6.3 years, the biochemical remission of disease was observed in 13 patients (59%) [44].…”

Section: • Pituitary Adenomamentioning

confidence: 99%

Radiosurgery and Hypofractionated Stereotactic Irradiation with Photons or Protons for Tumours of the Skull Base

Amelio¹,

Cianchetti²,

Rombi³

et al. 2013

Cancer Treatment - Conventional and Innovative Approaches

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“…With prices exceeding $100 million per unit, the cost-benefit ratio remains to be accurately described; efficacy data are still maturing. Diseases for which benefits have been seen with charged particles include uveal melanomas, 51 optic pathway gliomas, 52 skull-based tumors, 53 pituitary adenomas, 54 acoustic neuromas, 55 nasopharynx and paranasal sinuses, 56,57 spinal cord tumors, 58,59 prostate cancer, 60,61 lung cancer, [62][63][64][65] gastrointestinal malignancies, [66][67][68] and pediatric cancers. 69 …”

Section: Charged Particlesmentioning

confidence: 99%

Radiation Techniques in Neuro-Oncology

Khuntia

Mehta

2009

Neurotherapeutics

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Summary: Radiation therapy plays a critical role in the management of tumors of the brain. A variety of radiotherapy techniques have been used to treat these tumors. This review describes both classic and more recent and advanced techniques available to manage these tumors. Included is a discussion of standard two-and three-dimensional radiation, as well as intensity-modulated radiotherapy, image-guided radiation therapy, stereotactic radiosurgery, and heavy particles.

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Fractionated proton beam irradiation of pituitary adenomas

Cited by 84 publications

References 33 publications

Radiation-induced hypopituitarism

Radiation-induced hypopituitarism

Radiosurgery and Hypofractionated Stereotactic Irradiation with Photons or Protons for Tumours of the Skull Base

Radiation Techniques in Neuro-Oncology

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