Fractionated high-dose-rate brachytherapy as monotherapy in prostate cancer: Does implant displacement and its correction influence acute and late toxicity?

Aluwini, S.; Busser, W.; Baartman, Lizette E.A.; Bhawanie, A.; Alemayehu, Wendimagegn; Boormans, Joost L.; Kolkman-Deurloo, I.K.K.

doi:10.1016/j.brachy.2016.05.008

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…In our study, perineal oedema, movement of the prostate, and prostate oedema mainly occurred from day 1 to 2 and only prostate oedema occurred between day 2 and 3. Previous studies have shown that a larger amount of oedema occurs on the second than the third day (7,8), which the finding from our study is consistent with. Perineal oedema and movement of the prostate cause displacement of applicators, resulting in changes in dose distribution.…”

Section: Discussionsupporting

confidence: 93%

“…However, displacement of applicators may occur between fractions and the reliability of treatment is reduced if displacement occurs. In fractionated HDR-BT, ensuring geometrical reproducibility is important for dose concentration (6)(7)(8)(9)13). To solve this issue, in our study, we replanned every day using daily CT simulation images.…”

Section: Discussionmentioning

confidence: 99%

“…The dosimetric advantage of HDR-BT relies on the correct positioning of applicators to the prostate and the organs at risk. Several studies have reported that displacement of applicators occurs between fractions, and conformal, highdose delivery is not achieved if adequate correction cannot be performed (6)(7)(8). However, there are no standard criteria for correcting the treatment plan, such as through the correction of an applicator or replanning, and the optimum correction method is unclear.…”

mentioning

confidence: 99%

“…To the best of our knowledge, no reports have described quantitative assessment of perineal oedema. In evaluation of changes in a dose-volume histogram, several reports have shown that changes occur from the first to the second day but few reports have shown changes after the second day (6)(7)(8)(9). Therefore, some correction, such as correction of applicators or replanning appears to be necessary on the second day but whether correction on the third day is necessary is unclear.…”

mentioning

confidence: 99%

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Assessment of Daily Replanning and Geometrical Variation of High-dose-rate Brachytherapy for the Prostate

et al. 2020

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Background: The present study aimed to estimate geometric changes in applicators and prostate over 3 days in patients with high-dose-rate brachytherapy (HDR-BT) and to assess the need for daily replanning. Patients and Methods: This study retrospectively investigated 18 patients who underwent HDR-BT as monotherapy from February 2016 to October 2018. Results: Without replanning, the planning target volume coverage significantly worsened on day 2 (p<0.001) and day 3 (p=0.003). The minimum dose distributed to the highest irradiated rectal volume of 5 cc became significantly higher on day 2 (p=0.02), and the maximum dose distributed to the urethra became significantly higher on day 2 (p=0.01). Conclusion: Conformal, high-dose delivery of HDR-BT is impaired without replanning not only on the second day but also on the third day. Daily replanning is required for achieving accuracy of HDR-BT.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Assessment of Daily Replanning and Geometrical Variation of High-dose-rate Brachytherapy for the Prostate

et al. 2020

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“…For prostate BT, implant displacements may occur due to organ movement and the development of peri-prostatic oedema between fractions [6,23]. EMT has the potential to detect catheter movement between fractions as well as possible reconstruction errors.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of dwell position detection with a combined electromagnetic tracking brachytherapy system for treatment verification in pelvic brachytherapy

Heerden

Schiphof-Godart

Christianen

et al. 2021

Radiotherapy and Oncology

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Background and purpose: To investigate the accuracy of dwell position detection with a combined electromagnetic tracking (EMT) brachytherapy (BT) system for treatment verification, by quantifying positional errors due to EM field interference in typical pelvic BT clinical settings. Materials and methods: Dedicated prostate and cervix BT phantoms were imaged with CT. For the cervix phantom, the Utrecht applicator + interstitial catheters were used. The implants were reconstructed and treatment plans were created with 270/65 dwell positions for the prostate/cervix phantom. Next, EMT experiments were performed in clinical BT settings using a prototype of a combined EMT/BT system. We quantified positional errors due to EM field interference from surrounding equipment by comparing planned and EMT-measured dwell positions. The mean residual error between planned and EMTmeasured dwell positions was calculated in the prostate interstitial catheters and in the whole cervix implant including the applicator. For the cervix phantom, the analysis was repeated for only the interstitial catheters. Results: Mean residual errors of less than 0.5/0.4 mm in the prostate/cervix catheters were found. For the whole cervix implant including the applicator, large deviations up to 2.4 mm were found. Compared to the interference free set-up, the CT and patient bed environments showed larger residual errors in the interstitial catheters, but residual errors remained <1 mm in all cases. Conclusion: Dwell position detection with the combined system in interstitial catheters is sufficiently accurate to perform EMT-based treatment verification. The effect of EM interference from the surrounding equipment was limited.

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Needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer evaluated by repeated MRI

et al. 2018

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Fractionated high-dose-rate brachytherapy as monotherapy in prostate cancer: Does implant displacement and its correction influence acute and late toxicity?

Cited by 7 publications

References 32 publications

Assessment of Daily Replanning and Geometrical Variation of High-dose-rate Brachytherapy for the Prostate

Assessment of Daily Replanning and Geometrical Variation of High-dose-rate Brachytherapy for the Prostate

Accuracy of dwell position detection with a combined electromagnetic tracking brachytherapy system for treatment verification in pelvic brachytherapy

Needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer evaluated by repeated MRI

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