Fractionated half–body irradiation (HBI) for the rapid palliation of widespread, symptomatic, metastatic bone disease: a randomized Phase III trial of the International Atomic Energy Agency (IAEA)

New Approach for Treatment of Vertebral Metastases Using Intensity-Modulated Radiotherapy*

“…A single dose or fractionated half-body irradiation has been applied for widespread metastatic bone lesions [17,19,21]. On the other hand, a surgical procedure should be considered whenever cortical erosion of a weight-bearing area may cause a pathologic fracture.…”

“…With regard to different therapeutic goals, the dose concepts and fractionation schedules should be adapted individ ually [18]. In this study, the median prescribed dose was 40 Gy (range, 16-67.5 Gy), the median fraction dose was 6 Gy (range, 2.8-20 Gy), and the median fraction number was 5 (range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Based on each patient condition, we decided the treatment schedules adjusted by BED 10 and BED 2 .…”

A novel study investigating the therapeutic outcome of patients with lytic, mixed and sclerotic bone metastases treated with combined radiotherapy and ibandronate

“…Complete pain relief was reported in 53% of patients and 30% experienced partial pain relief. In cases of widespread metastatic skeletal disease whole-body or half-body irradiation can offer symptomatic pain relief in 91% of patients, 45% experiencing complete pain response [18].…”

Management of Bone Metastases in Patients with Castration-Resistant Prostate Cancer

“…Historically, the treatment of multiple bone metastases comprises half-body irradiation [43,44] and systemic β-emitter radionuclides such as strontium-89 [45] and samarium-153. The side effects of radiopharmaceuticals and half-body irradiation include bone marrow suppression, which may be worse in heavily pretreated patients [32] and may compromise future chemotherapy treatment.…”