Fractionated Casein Ingredients—Recaldent

Reynolds, Eric C.

doi:10.1016/b978-0-12-818766-1.00136-7

Cited by 1 publication

(2 citation statements)

References 67 publications

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“…In regard to these results, ROS levels were not accentuated by the SSL‐irradiation (14.5 kJ m −2 UVA or 29 kJ m −2 UVA). The decrease in type I ROS following CSE treatment could indicate that CSE has an antioxidant potential, or at least that it contains a reducing compound, such as formic acid, ascorbic acid, citric acid, hydrogen sulfide and carbon disulfide, which are found in cigarette smoke and have a reducing potential (37,38).…”

Section: Resultsmentioning

confidence: 99%

“…Human primary keratinocytes were obtained from the skin biopsies of breast reduction surgeries. Donors were all Caucasian females aged between 38 and 49 years old (38,46 and 49 years old). The study was in agreement with the Declaration of Helsinki and performed under the guidelines of the Research Ethics Committee of the "Centre Hospitalier Universitaire (CHU) de Qu ebec-Universit e Laval" (ethics code: DR-002-1121, protocol renewal approved on January 12 th , 2022).…”

Section: Methodsmentioning

confidence: 99%

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Toxic Interaction Between Solar Radiation and Cigarette Smoke on Primary Human Keratinocytes

Grenier

Morissette

Rochette

et al. 2023

Photochem & Photobiology

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Solar radiation and cigarette smoke are two environmental risk factors known to affect skin integrity. Although the toxic effects of these factors on skin have been widely studied separately, few studies have focused on their interaction. The objective of this study was to evaluate and understand the synergistic harmful effects of cigarette smoke and solar rays on human primary keratinocytes. The keratinocytes were exposed to cigarette smoke extract (CSE) and then irradiated with a solar simulator light (SSL). The viability, as determined by measuring metabolic activity of skin cells, and the levels of global reactive oxygen species (ROS) were evaluated after exposure to CSE and SSL. The combination of 3% CSE with 29 kJ m−2 UVA caused a decrease of 81% in cell viability, while with 10% to 20% CSE, the cell viability was null. This phototoxicity was accompanied by an increase in singlet oxygen but a decrease in type I ROS when CSE and SSL were combined in vitro. Surprisingly, an increase in the CSE's total antioxidant capacity was also observed. These results suggest a synergy between the two environmental factors in their effect on skin cells, and more precisely a phototoxicity causing a drastic decrease in cell viability.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%