Fractional protein synthesis rate and polyamine concentrations in tissues of Merino sheep selected for gastrointestinal nematode resistance

Liu, Shimin; Smith, Tanya; Briegel, J. R.; Gao, Shuo; Peng, W.K.

doi:10.1016/j.livsci.2006.07.004

Cited by 6 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dullness, depression, emaciation, weakness, diarrheic feces, soiled hind quarters, fever and anemia had earlier been demonstrated in animals heavily infested with H. contortus (Soulsby 1982) as well as with M. expansa (Miglani et al 1993;Kar et al 2007). The dullness and depression of the animals observed in the present study could be attributed to hypoglycemia in the infected individuals, whereas, weakness and emaciation recorded could easily be correlated with hypoproteinemia leading to loss in body muscles during severe gastrointestinal parasitic infestations (Ahmed et al 2015) and also due to reduced protein synthesis in the muscles in gastrointestinal nematode infections (Liu et al 2007). Diarrheic feces and soiled hind quarters had also earlier been reported in small ruminants infected with M. expansa (Kar et al 2007).…”

Section: Discussionmentioning

confidence: 51%

Gastrointestinal parasitic infections in Indian Gaddi (goat) breed bucks: clinical, hemato-biochemical, parasitological and chemotherapeutic studies

et al. 2017

View full text Add to dashboard Cite

The present study was envisaged with an aim to evaluate gastrointestinal parasitic infections in a herd of conserved Gaddi (goat) breed bucks (6-9 months of age) kept on semi-intensive feeding management. The individuals (n = 20) representing the herd were selected and divided into two groups; group I (n = 10), clinically ill and group II (n = 10), sub clinically infected individuals. The clinical examination revealed anemia, emaciation and rise in body temperature of the individuals of group I as compared to group II. The detailed copro-parasitological examination and copro-culture revealed the presence of eggs of and larvae of species, respectively in the fecal samples of both clinically and sub clinically infected individuals. The hemato-biochemical parameters proved vital indicators of the health of group I individuals and exhibited decline in the values of hemoglobin, packed cell volume and total erythrocyte count as compared to group II. Significant ( < 0.05) hypoproteinemia, hypoalbuminemia, hypoglycemia and increased levels of alanine aminotransferase and aspartate aminotransferase were observed in infected individuals as compared to treated ones. The detailed parasitological, hemato-biochemical observations and clinical findings elucidated and supported the presence of concurrent gastrointestinal parasitism in the herd. The significant improvement was observed in the health status of the herd after 1 month of the therapeutic management, which was carried out using a combination of fenbendazole and praziquantel in both clinically and sub clinically infected individuals.

show abstract

Section: Discussionmentioning

confidence: 51%

Gastrointestinal parasitic infections in Indian Gaddi (goat) breed bucks: clinical, hemato-biochemical, parasitological and chemotherapeutic studies

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Methionine, as the only essential sulphur-containing AA (SAA) and a precursor to a number of other SAA ( 25 ) , plays pivotal roles in protein synthesis, maintenance of gut functions and regulation of the mucosal response to antigens ( 25 , 26 ) . There is evidence suggesting that demand for SAA may be increased during gastrointestinal nematode infections ( 27 , 28 ) , probably due to the loss of SAA-rich endogenous protein via increased sloughing of epithelial cells and especially mucin secretion ( 29 ) . Importantly, methionine supplementation of growing rats infected with Nippostrongylus brasiliensis has resulted in a reduction of worm burdens ( 30 ) .…”

mentioning

confidence: 99%

Leucine and methionine deficiency impairs immunity to gastrointestinal parasites during lactation

et al. 2012

View full text Add to dashboard Cite

Lactating rats reinfected with Nippostrongylus brasiliensis fed low-crude protein (CP) foods show reduced lactational performance and less resistance to parasites compared with their high-CP counterparts. Here, we hypothesised that feeding high-CP foods deficient in specific essential amino acids (AA) would result in similar penalties. Second-parity lactating rats, immunised with 1600 N. brasiliensis infective larvae before mating, were fed foods with either 250 (high protein; HP) or 150 (low protein; LP) g CP/kg, or were HP deficient in either leucine (HP-Leu) or methionine (HP-Met). On day 1 of lactation, litter size was standardised at twelve pups. On day 2, dams were either reinfected with 1600 N. brasiliensis larvae or sham-infected with PBS. Dams and litters were weighed daily until either day 8 or 11, when worm burdens, and inflammatory cells and systemic levels of N. brasiliensis-specific Ig isotypes were assessed. Data from five out of sixteen HP-Met rats were omitted due to very high levels of food refusals from parturition onwards. Relative to feeding HP foods, feeding LP, HP-Met and HP-Leu foods reduced dam weight gain and, to a lesser extent, litter weight gain, and increased the number of worm eggs in the colon, indicative of a reduction in resistance to parasites. However, only feeding LP and HP-Leu foods resulted in increased worm numbers, while none of the feeding treatments affected systemic Ig, mast and goblet cells, and eosinophil numbers. The present results support the view that resistance to parasites during lactation may be sensitive to specific essential AA scarcity.

show abstract

Amino Acids in the Nutrition and Production of Sheep and Goats

Cao

Yao

Sun

et al. 2021

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Fractional protein synthesis rate and polyamine concentrations in tissues of Merino sheep selected for gastrointestinal nematode resistance

Cited by 6 publications

References 38 publications

Gastrointestinal parasitic infections in Indian Gaddi (goat) breed bucks: clinical, hemato-biochemical, parasitological and chemotherapeutic studies

Gastrointestinal parasitic infections in Indian Gaddi (goat) breed bucks: clinical, hemato-biochemical, parasitological and chemotherapeutic studies

Leucine and methionine deficiency impairs immunity to gastrointestinal parasites during lactation

Amino Acids in the Nutrition and Production of Sheep and Goats

Contact Info

Product

Resources

About