Fractional nonablative 1540 nm laser resurfacing for thermal burn scars: A randomized controlled trial

Hædersdal, Merete; Moreau, Karen Estell R.; Beyer, Ditte Maria; Nymann, Peter; Alsbjørn, Bjarne

doi:10.1002/lsm.20756

Cited by 106 publications

(85 citation statements)

References 24 publications

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“…Patients were treated with 3 treatments, at 4-week intervals using 10-mm handpiece, 15 ms, 21 to 40 J/cm 2 , 3 to 4 passes, and results showed moderate to significant improvement in skin texture compared to untreated controls. The authors noticed that superficial burns did better than deep burns, which could be a result of the utilized laser's ability to cause thermal damage to a depth of 400 to 1000 nm, leaving the deeper fibrous tissues unaffected [50].…”

Section: Burn Scarsmentioning

confidence: 99%

Scar Treatment with Lasers: A Review and Update

Harithy

Pon

2012

Curr Derm Rep

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Section: Burn Scarsmentioning

confidence: 99%

Scar Treatment with Lasers: A Review and Update

Harithy

Pon

2012

Curr Derm Rep

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“…Postoperative period -6 months Postoperative period -1 year Therapeutic measures such as use of corticosteroids, botulinum toxin, vitamins A and E, silicone tapes and laser e radiotherapy are used for prevention or in the presence of hypertrophic scars or keloids 3,[8][9][10][11] . This clinical, prospective, and randomized study was conducted with the same objective: the improvement of scars.…”

Section: Postoperative Period -1 Month Postoperative Period -3 Monthsmentioning

confidence: 99%

“…In their surgeries, they seek to conceal the scars by placing them according to the force lines of the skin in areas where they will not be visible or will be only minimally noticeable. When the scars are located in constantly exposed areas, as in the face, they use or conduct concealing therapeutic and cosmetic measures to make the scars less noticeable 3,[8][9][10][11] . Progress in studies of cellular and molecular biology may have a large impact on understanding the healing process and its clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Adipose tissue mature stem cells in skin healing: a controlled randomized study

Martins

Uebel

Silva³

2011

Rev. Bras. Cir. Plást. (Impr.)

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ORIGINAL ARtIcLeABSTRACT Background: The differences between fetal and adult scars suggest the possibility of manipulating skin scarring outcomes. This study aimed to assess whether the use of adult stem cells from adipose tissue is beneficial to skin healing. Methods: This was a randomized controlled study for which 18 patients were selected based on inclusion and exclusion criteria. The adult stem cells used were autologous and were extracted from infraumbilical adipose tissue prior to abdominoplasty. These cells were implanted into the surgical wound dermis in the suprapubic region before skin synthesis. The results were assessed blindly based on the Draaijers scale by three physicians and by the patients themselves in a self-assessment. Photometric assessment by digital photography was also performed. Results: Among the 18 operated patients, considering the surgical result, 17 (94.4%) had excellent or good results and one (5.5%) had wound dehiscence, which was considered a bad result. Considering skin healing in the searched area, there was no statistically significant difference in the photometric evaluation; in both the self-assessment by the patients and the physicians' assessment, the results were significantly in favor of intervention with stem cells (P = 0.12 and P = 0.003, respectively). Consideration of all assessments (physicians, patients and photometric) found a statistically significant difference in favor of the implantation of adult stem cells from adipose tissue (P <0.001). Conclusions: Skin healing results after implantation of adult stem cells derived from adipose tissue were satisfactory.Keywords: Stem cells. Wound healing. Abdomen/surgery. RESUMO Introdução:Fatores que diferenciam a cicatrização fetal e a do adulto instigam a possibilidade de manipulação das soluções de continuidade da pele. Este estudo teve como objetivo avaliar se o uso de células-tronco adultas do tecido adiposo é benéfico à cicatrização da pele. Método: Estudo controlado, randomizado, para o qual foram selecionadas 18 pacientes, considerando-se critérios de inclusão e exclusão. As células-tronco adultas utilizadas eram autólogas, extraídas do tecido adiposo da região infraumbilical, precedendo a realização da abdominoplastia. Essas células, antes da síntese da pele, foram implantadas na derme da ferida operatória, na região suprapúbica. A avaliação dos resultados foi realizada com base na escala de Draaijers, por três avaliadores médicos cegados, e pelas próprias pacientes, por autoavaliação. Foi realizada, também, avaliação fotométrica por fotografia digital. Resultados: Dentre as 18 pacientes operadas, sob o ponto de vista cirúrgico, 17 (94,4%) apresentaram resultados excelentes ou bons e uma (5,5%) apresentou deiscência de sutura, considerado mau resultado. Quanto à cicatrização da pele na área pesquisada, à avaliação fotométrica, não houve diferença estatisticamente significante; à autoavaliação pelas pacientes, os resultados atingiram nível de significância a favor da intervenção com células-tronco (P = 0,12); e à...

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“…Multiple studies report significant improvement in scar thickness, erythema, pruritus, and texture when the appropriate laser treatment has been utilized; these studies have examined surgical scars, hypertrophic scars, keloids, and burn scars. 42,43,44 PDL (585-595 nm) reduces hyperemia and edema of the immature burn scar. Fractional CO 2 laser (10,600 nm) corrects abnormal texture, thickness, and stiffness of more mature scars.…”

Section: Laser Therapymentioning

confidence: 99%

Emerging Therapies for Scar Prevention

Block

Gosain

2015

Advances in Wound Care

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Significance: There are *12 million traumatic lacerations treated in the United States emergency rooms each year, 250 million surgical incisions created worldwide every year, and 11 million burns severe enough to warrant medical treatment worldwide. In the United States, over $20 billion dollars per year are spent on the treatment and management of scars. Recent Advances: Investigations into the management of scar therapies over the last decade have advanced our understanding related to the care of cutaneous scars. Scar treatment methods are presented including topical, intralesional, and mechanical therapies in addition to cryotherapy, radiotherapy, and laser therapy. Critical Issues: Current treatment options for scars have significant limitations. This review presents the current and emerging therapies available for scar management and the scientific evidence for scar management is discussed. Future Directions: Based upon our new understanding of scar formation, innovative scar therapies are being developed. Additional research on the basic science of scar formation will lead to additional advances and novel therapies for the treatment of cutaneous scars.

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Fractional nonablative 1540 nm laser resurfacing for thermal burn scars: A randomized controlled trial

Abstract: Nonablative 1540 nm fractional laser improves burn scar texture, which raises a new potential for future burn scar treatment.

Cited by 106 publications

References 24 publications

Scar Treatment with Lasers: A Review and Update

Scar Treatment with Lasers: A Review and Update

Adipose tissue mature stem cells in skin healing: a controlled randomized study

Emerging Therapies for Scar Prevention

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