Fractional Esterification Rate of Cholesterol and Ratio of Triglycerides to HDL-Cholesterol Are Powerful Predictors of Positive Findings on Coronary Angiography

Fröhlich, Jiří; Dobiášová, M

doi:10.1373/clinchem.2003.022558

Cited by 246 publications

(199 citation statements)

References 80 publications

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“…These findings seem to reflect the metabolic alterations characteristic of DM2, with higher means for BMI, SP, DP, ApoB, TC, TG, logTG, logTG/HDL and BChE activities. The elevation of logTG/HDL in these patients indicates that they have a higher proportion of small and dense LDL particles (24) and, therefore, a higher risk for coronary artery disease (CAD). Table 2 shows the t-test results for the mean values of age and BChE activities in the DM1 and DM2 groups with the CHE2 C5-phenotype, compared to controls, and paired by sex and age.…”

Section: Resultsmentioning

confidence: 99%

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cwiertnia

Alcântara

Réa

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus. Subjects and methods: BChE activities (BChEA, AC 4/5 , AC OF and RC 5 ) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C 4/5 and C 5 complex were separated from other molecular forms (C OF ) using an acid agar gel. Results: The BChE activity (BChEA) and the absolute activities of C 4/5 (AC 4/5 ) and C OF (AC OF ) showed a high positive correlation coefficient to weight in the CHE2 C5-group, while the relative activity of C 5 complex (RC 5 ) showed a negative correlation to weight. Conclusions: The present study suggests that the positive correlation of the BChE activities to diabetes mellitus and to insulin resistance may depend on the CHE2 locus variability. High values of BChE activities were associated with insulin resistance only in CHE2 C5-diabetic patients, while in CHE2 C5+ diabetic patients, the presence of C 5 complex, especially in a relatively high proportion, leads to less fat storage and better protection against metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(1):60-7 Keywords BCHE and CHE2 loci; C 4/5 and C 5 complexes; obesity, insulin resistance; metabolic syndrome; serum cholinesterase RESUMO Objetivo: Investigar a associação entre as atividades (total e banda específica) da butirilcolinesterase (BChE) e diabetes melito. Sujeitos e métodos: As atividades da BChE (BChEA, AC 4/5 , AC OF e RC 5 ) foram analisadas em 101 pacientes diabéticos do tipo 1 (DM1) e 145 do tipo 2 (DM2) em relação aos fenótipos, ao peso e à incidência da síndrome metabólica. Os complexos C 4/5 e C 5 foram separados das outras formas moleculares (C OF ), usando gel de ágar ácido. Resultados: A atividade da BChE (BChEA) e as atividades absolutas de C 4/5 (AC 4/5 ) e de C OF (AC OF ) mostraram altos coeficientes de correlações positivos com peso no grupo de CHE2 C5-, enquanto a atividade relativa do complexo C 5 (RC 5 ) mostrou correlação negativa com o peso. Conclusões: O presente estudo sugere que as correlações positivas das atividades da BChE com diabetes melito e com a resistência à insulina podem depender da variabilidade do loco CHE2. Altos valores nas atividades da BChE estão associados com a resistência à insulina somente nos pacientes diabéticos CHE2 C5-, enquanto nos pacientes diabéticos CHE2 C5+ a presença do complexo C 5 , especialmente em alta proporção relativa, leva a um menor estoque de gordura e à maior proteção contra a síndrome metabólica. Arq Bras Endocrinol Metab. 2010;54(1):60-7 DescritoresLocos BCHE e CHE2; complexos C 4/5 e C 5 ; obesidade, resistência à insulina; síndrome metabólica; colinesterase do soro

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Section: Resultsmentioning

confidence: 99%

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cwiertnia

Alcântara

Réa

et al. 2010

Arq Bras Endocrinol Metab

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“…In this context, the plasma parameter log (TG/HDL-C), well known as 'atherogenic index of plasma' (AIP), has been considered as a marker of plasma atherogenicity, since it indicates the lipoprotein particle size (4) and is associated with coronary artery disease (5).…”

Section: Introductionmentioning

confidence: 99%

Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men

Caminhotto

Fonseca

Castro

et al. 2015

Arch. Endocrinol. Metab.

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Background:The Atkins diet program is a great example of the application of low carbohydrate diets for obesity, with the intention of weight loss and improvement in cardiovascular risk (CV risk). A good CV risk predictor is the atherogenic index of plasma (AIP) calculated as log (TG/HDL [mmol]), which is strongly affected by serum triglycerides, which in turn is associated with the carbohydrate intake. This study determined the effect of the initial phase of Atkins diet program, consisting in 20 g/day of carbohydrate intake with positive urinary ketones measure, in AIP of 12 adult overweight trained adapted men. The AIP was calculated before and after intervention. Results: After 14 days, BMI and triglycerides decreased significantly, while HDL-C increased. No alterations were described in LDL plasmatic concentration. Prior to the diet, 58.3% of subjects presented high CV risk and after 14 days of the diet program only 33.3% of subjects were classified as high CV risk, while more than 66% were low CV risk. The intervention was effective in 11 of 12 participants. However, in one person the dietary intervention increased AIP index. Conclusion: The initial phase of Atkins diet program could significantly decrease the AIP in 11 of 12 adult overweight trained adapted men. Dietary individual responses need to be more studied. Arch Endocrinol Metab. 2015;59(6):568-71

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“…16 Logarithmic ratio of triglycerides to HDL was defined as atherogenic index of plasma (AIP) and this index was found to be closely associated with atherosclerosis in general population. 17 However, in the literature, data regarding the AIP in ESRD patients are scant. Hence, we aimed to investigate the relationship between AIP and EAT in ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD) and to compare these results with the others that obtained from healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients

Erdur¹,

Tonbul²,

Özbiner

et al. 2013

Renal Failure

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Fractional Esterification Rate of Cholesterol and Ratio of Triglycerides to HDL-Cholesterol Are Powerful Predictors of Positive Findings on Coronary Angiography

Cited by 246 publications

References 80 publications

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men

The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients

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