Fractional amplitude of low-frequency fluctuation changes in monkeys with spinal cord injury: A resting-state fMRI study

Rao, Jia‐Sheng; Ma, Mingxing; Zhao, Chen; Zhang, Aifeng; Yang, Zhaoyang; Liu, Zuxiang; Li, Xiaoguang

doi:10.1016/j.mri.2014.02.001

Cited by 24 publications

(19 citation statements)

References 47 publications

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“…In accordance, restingstate functional MRI showed alterations in spontaneous neuronal activity in several brain regions in monkeys [67] as well as in rats [62 & ] with a thoracic hemisection. These observations might further help to understand the pathophysiological mechanisms behind these changes.…”

Section: Animal Models Of Spinal Cord Injury: Invasive Tracking Of Trmentioning

confidence: 57%

“…3 [67,68], as in human SCI [25,34]. In addition, cortical reorganization of S1 increased over time and correlated with the rostral, anterio-posterior diameter of the spinal cord indicating that a more severe SCI leads to greater cortical reorganization.…”

Section: Animal Models Of Spinal Cord Injury: Invasive Tracking Of Trmentioning

confidence: 89%

“…atrophy rates and possible recovery) to be determined more accurately via longitudinal image registration procedures [78]. [67].…”

Section: Future Directionsmentioning

confidence: 99%

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Tracking trauma-induced structural and functional changes above the level of spinal cord injury

Huber

Curt

Freund

2015

Current Opinion in Neurology

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PURPOSE OF REVIEW: This review will highlight the latest findings from neuroimaging studies that track structural and functional changes within the central nervous system at both the brain and spinal cord levels following acute human spinal cord injury (SCI). The putative, underlying biological mechanisms of structural change (e.g. degradation of neural tissue) rostral to the lesion site will be discussed in relation to animal models of SCI and their potential value in clinical studies of human SCI. RECENT FINDINGS: Recent prospective studies in human acute SCI have begun to reveal the timecourse, spatial distribution and extent of structural changes following an acute SCI and their relation to functional outcome. Adaptive changes in sensory and motor pathways above the level of the lesion have prognostic value and complement clinical readouts. SUMMARY: The introduction of sensitive neuroimaging biomarkers will be an essential step forward in the implementation of interventional trials in which proof-of-concept is currently limited to clinical readouts, but more responsive measures are required to improve the sensitivity of clinical trials. Purpose of review This review will highlight the latest findings from neuroimaging studies that track structural and functional changes within the central nervous system at both the brain and spinal cord levels following acute human spinal cord injury (SCI). The putative, underlying biological mechanisms of structural change (e.g. degradation of neural tissue) rostral to the lesion site will be discussed in relation to animal models of SCI and their potential value in clinical studies of human SCI. Recent findingsRecent prospective studies in human acute SCI have begun to reveal the time-course, spatial distribution and extent of structural changes following an acute SCI and their relation to functional outcome. Adaptive changes in sensory and motor pathways above the level of the lesion have prognostic value and complement clinical readouts. SummaryThe introduction of sensitive neuroimaging biomarkers will be an essential step forward in the implementation of interventional trials in which proof-of-concept is currently limited to clinical readouts, but more responsive measures are required to improve the sensitivity of clinical trials.

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Section: Animal Models Of Spinal Cord Injury: Invasive Tracking Of Trmentioning

confidence: 57%

Section: Animal Models Of Spinal Cord Injury: Invasive Tracking Of Trmentioning

confidence: 89%

See 1 more Smart Citation

Tracking trauma-induced structural and functional changes above the level of spinal cord injury

Huber

Curt

Freund

2015

Current Opinion in Neurology

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“…Animal studies on resting-state connectivity in SCI have demonstrated changes between different regions of sensorimotor cortex [ 27 , 28 ]. However, how these alterations in activation patterns of the sensorimotor network affect the overall resting state connectivity in SCI patients is not yet understood In humans, studies looking at changes in cortex have been focused on more acute timeframes and have studied multiple spinal cord injury grades [ 29 – 31 ].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study

Oni-Orisan

Kaushal

et al. 2016

PLoS ONE

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Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients. The interruption to structural integrity of the spinal cord and the resultant disrupted flow of bidirectional communication between the brain and the spinal cord might contribute to the observed dynamic reorganization (neural plasticity). However, the effect of SCI on brain resting-state connectivity patterns remains unclear. We undertook a prospective resting-state fMRI (rs-fMRI) study to explore changes to cortical activation patterns following SCI. With institutional review board approval, rs-fMRI data was obtained in eleven patients with complete cervical SCI (>2 years post injury) and nine age-matched controls. The data was processed using the Analysis of Functional Neuroimages software. Region of interest (ROI) based analysis was performed to study changes in the sensorimotor network using pre- and post-central gyri as seed regions. Two-sampled t-test was carried out to check for significant differences between the two groups. SCI patients showed decreased functional connectivity in motor and sensory cortical regions when compared to controls. The decrease was noted in ipsilateral, contralateral, and interhemispheric regions for left and right precentral ROIs. Additionally, the left postcentral ROI demonstrated increased connectivity with the thalamus bilaterally in SCI patients. Our results suggest that cortical activation patterns in the sensorimotor network undergo dynamic reorganization following SCI. The presence of these changes in chronic spinal cord injury patients is suggestive of the inherent neural plasticity within the central nervous system.

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“…Up to now, various interventional therapies have been attempted in rodent SCI models to improve and restore the residual locomotor functions. [1][2][3][4][5] Because of the striking similarities of neuroanatomical and physiological structures between humans and non-human primates, 6 together with prominent advantages in pre-clinical SCI studies, 7 a large number of non-human primates [8][9][10][11][12][13] have been used to assess the SCI-induced variations, among which locomotor changes are considered the most critical.…”

Section: Introductionmentioning

confidence: 99%

Combination of kinematic analyses and diffusion tensor tractrography to evaluate the residual motor functions in spinal cord‐hemisected monkeys

Zhao

Song

Rao

et al. 2017

J of Medical Primatology

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Fractional amplitude of low-frequency fluctuation changes in monkeys with spinal cord injury: A resting-state fMRI study

Cited by 24 publications

References 47 publications

Tracking trauma-induced structural and functional changes above the level of spinal cord injury

Tracking trauma-induced structural and functional changes above the level of spinal cord injury

Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study

Combination of kinematic analyses and diffusion tensor tractrography to evaluate the residual motor functions in spinal cord‐hemisected monkeys

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