Fraction of exhaled nitric oxide in healthy Chilean schoolchildren aged 8–15 years

Mallol, Javier; Aguirre, Viviana; Córdova, Pablo; Cortez, E.; Gallardo, Alejandro; Riquelme, Carlos

doi:10.1016/j.aller.2014.07.003

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…This pattern was observed both for year 3 BMI% and time-varying BMI%. Previous studies have found no association between F ENO 50 in children and weight [6][7][8], body surface area [8] or BMI [7,10,29], with exception of a reported negative association with BMI z-score, primarily in atopic children [30] and weak positive correlation for body surface area [7]. BMI%, which is considered in the present study, may better represent being under-/overweight at a given age and sex.…”

Section: Discussioncontrasting

confidence: 68%

“…Prior studies of the distribution and determinants of F ENO 50 in healthy paediatric populations were based on single cross-sectional measurements among children across a range of ages [5][6][7][8][9][10][11], which may have missed important patterns in F ENO 50 change as children grow. Serial measurements within the same set of children as they age are likely to be more informative for understanding trajectory of F ENO 50 across childhood and adolescence as well as potential determinants of this evolution.…”

Section: Introductionmentioning

confidence: 99%

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Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period

et al. 2020

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Fractional exhaled nitric oxide (FENO50), a marker of allergic airway inflammation, is used in respiratory research and asthma clinical care; however, its trajectory with increasing age during childhood has not been well characterised. We examined FENO50 longitudinally during a period of important somatic growth to describe trajectories across childhood and adolescence in healthy participants and evaluate clinical factors as potential determinants of trajectories.FENO50 was collected at six visits over 8 years in a population-based cohort of 1791 schoolchildren without asthma (median age at entry 8.4 years). Smooth sex-specific FENO50 trajectories were estimated using generalised additive mixed models, with participant-level random effects. We evaluated whether sex-specific trajectories were influenced by race/ethnicity, body mass index (BMI) percentile, allergic rhinitis or puberty.Different FENO50 patterns were observed by sex in later childhood and several factors were associated with either FENO50 level or change in FENO50 as participants aged. FENO50–age trajectories were similar by sex until age ∼11.5 years, after which males had greater FENO50 change than females. This divergence in FENO50–age trajectories coincides with puberty. Males with higher starting BMI percentile had attenuated FENO50–age slopes. Among males, FENO50 levels were lower in non-Hispanic white subjects. Among both sexes, participants with rhinitis had higher FENO50. FENO50 levels within individuals tracked over time; however, there was considerable variation in FENO50 patterns across participants.FENO50 trajectories from longitudinal data provide evidence of sex differences coinciding with puberty, suggesting potential hormone link. Improved understanding of determinants of FENO50 trajectories is needed to realise the potential for using individualised predicted FENO50 trajectories.

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Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period

et al. 2020

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“…NO formation is already detected at birth [ 22 , 23 ] and is important in humans, which are under strict biological control. NO formation is a complex and energy consuming process whereby NO is produced by inducible NO synthase in the airway epithelium.…”

Section: Discussionmentioning

confidence: 99%

Reference Ranges and Determinant Factors for Fractional Exhaled Nitric Oxide in a Healthy Saudi Adult Population

Habib

Alzoghaibi

Habib

et al. 2020

Med Sci Monit Basic Res

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Background Fractional exhaled nitric oxide (FENO) has emerged as a promising marker in respiratory research. The aim of this study was to determine the reference range values of FENO for healthy Saudi adults and the factors associated with FENO levels. Material/Methods This cross-sectional study was conducted at the Department of Physiology, King Saud University, Riyadh, Saudi Arabia, from January 2016 to August 2017. A total of 429 healthy Saudi adults were initially recruited. The final selection included 412 participants, consisting of 307 men and 105 women. FENO measurements were performed according to the current recommendations of the American Thoracic Society. Results We observed that the FENO levels of women were significantly lower than those of men (18.6 vs. 21.3, P =0.009). In women, the measured FENO ranged from 5.7 ppb to 42 ppb, and in men from 5.0 ppb to 55.0 ppb. The mean FENO level in the entire study population was 20.6, with a range of 5.0 ppb to 55.0 ppb. The difference became non-significant when we calculated the FENO after adjusting for body surface area by different percentile distributions. Multiple linear regression analysis showed that body surface area and weight were significant predictors of FENO levels. Conclusions In this study, FENO levels were significantly affected by demographic variables. Therefore, it is important to consider the factors influencing FENO values to make a valid clinical interpretation.

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“…However, reports on the relationship between FeNO levels and age compared subjects aged 35–44 years to those aged 64 years and older [18], or between subjects aged less than 60 years to those aged 60 years and older [19]: that is, each group covered a wide age range. Reports on children include a study finding no difference in FeNO level by age in children aged 5–16 years [20], and a study that demonstrated no correlation between FeNO level and age in a group of children aged 8–15 years [21], suggesting that it was highly unlikely that the 1-year difference in age was responsible for the difference in FeNO levels.…”

Section: Discussionmentioning

confidence: 99%

School-aged asthma children with high fractional exhaled nitric oxide levels and lung dysfunction are at high risk of prolonged lung dysfunction

Saito

Kikuchi

Lefor

2019

Asia Pacific Allergy

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BackgroundLong-term management of bronchial asthma based on the fractional exhaled nitric oxide (FeNO) value alone is not conclusive yet. Therefore, we combined FeNO testing and spirometry, a commonly used test in routine practice, to evaluate acute exacerbation and respiratory function in children with bronchial asthma.ObjectiveWe combined FeNO testing and spirometry, commonly used in routine practice, to evaluate acute exacerbations and respiratory function in children with bronchial asthma.MethodsSubjects were school aged children 7 years and older with bronchial asthma who underwent FeNO testing in January 2015 to May 2016. We evaluated the changes in the frequency of acute exacerbations and respiratory function in the 30 subsequent months. Subjects were divided into 2 groups: those with initial FeNO levels ≥ 21 parts per billion (ppb) (high FeNO) and < 20 ppb (normal FeNO) groups.ResultsThere were 48 children (33 boys) in the high FeNO group and 68 children (46 boys) in the normal FeNO group. Spirometry was conducted on 83 children (72%) prior to the initial FeNO test, revealing no difference in the ratio of detecting lung dysfunction between the 2 groups. The observation period was 25.8 ± 0.7 and 24.7 ± 0.6 months for the high and normal FeNO groups, respectively. The children in the high FeNO group with lung dysfunction in the initial FeNO test continued to exhibit lung dysfunction at the test at 30 months. In the normal FeNO group, even if lung dysfunction was observed at the initial FeNO, it improved within the 20-month point, and the improvement was maintained thereafter.ConclusionChildren with bronchial asthma with high FeNO levels and lung dysfunction are at a higher risk of prolonged lung dysfunction.

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Fraction of exhaled nitric oxide in healthy Chilean schoolchildren aged 8–15 years

Abstract: This study suggests that FENO values higher than 27ppb are likely to be abnormal and would reflect airway inflammation in children as those in the present study.

Cited by 8 publications

References 23 publications

Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period

Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period

Reference Ranges and Determinant Factors for Fractional Exhaled Nitric Oxide in a Healthy Saudi Adult Population

School-aged asthma children with high fractional exhaled nitric oxide levels and lung dysfunction are at high risk of prolonged lung dysfunction

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