Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway

Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects

“…Similarly, the phytochemical carvacrol induces neurite outgrowth by activating the TrkA receptor and its downstream pathways independently of NGF ( Sisti et al, 2021 ). Furthermore, the NGF-signaling pathway is activated by crotapotin, a component of snake venom, which suggests neuroprotective effects against PD-mimetic toxins ( Bernardes et al, 2024 ). These findings underscore the tractability of the NGF pathway for pharmacological intervention.…”

Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects

“…Similarly, the phytochemical carvacrol induces neurite outgrowth by activating the TrkA receptor and its downstream pathways independently of NGF ( Sisti et al, 2021 ). Furthermore, the NGF-signaling pathway is activated by crotapotin, a component of snake venom, which suggests neuroprotective effects against PD-mimetic toxins ( Bernardes et al, 2024 ). These findings underscore the tractability of the NGF pathway for pharmacological intervention.…”

Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects

“…Similarly, the phytochemical carvacrol induces neurite outgrowth by activating the TrkA receptor and its downstream pathways independently of NGF ( Sisti et al, 2021 ). Furthermore, the NGF-signaling pathway is activated by crotapotin, a component of snake venom, which suggests neuroprotective effects against PD-mimetic toxins ( Bernardes et al, 2024 ). These findings underscore the tractability of the NGF pathway for pharmacological intervention.…”

Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects

“…Similarly, the phytochemical carvacrol induces neurite outgrowth by activating the TrkA receptor and its downstream pathways independently of NGF ( Sisti et al, 2021 ). Furthermore, the NGF-signaling pathway is activated by crotapotin, a component of snake venom, which suggests neuroprotective effects against PD-mimetic toxins ( Bernardes et al, 2024 ). These findings underscore the tractability of the NGF pathway for pharmacological intervention.…”