We develop a Clifford algebra approach for 3D Ising model. We first note the main difficulties of the problem for solving exactly the model and then emphasize two important principles (i.e., Symmetry Principle and Largest Eigenvalue Principle) that will be used for guiding the path to the desired solution. By utilizing somein Jordan algebras is applied instead of the usual matrix multiplication AB (Theorem IV: Commutation Theorem).. This can be realized by time-averaging t systems of the 3D Ising models with time evaluation. In order to determine the rotation angle for the local transformation, the star-triangle relationship of the 3D Ising model is employed for Curie temperature, which is the solution of generalized Yang-Baxter equations in the continuous limit. Finally, the topological phases generated on the eigenvectors are determined, based on the relation with the Ising gauge lattice theory. ..