2009
DOI: 10.1016/j.jns.2008.12.023
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Fractal dimension analysis of grey matter in multiple sclerosis

Abstract: The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of a complex object. Among other applications, FD has been used to identify abnormalities of the human brain in conventional magnetic resonance imaging (MRI), including white matter abnormalities in patients with Multiple Sclerosis (MS). Extensive grey matter (GM) pathology has been recently identified in MS and it appears to be a key factor in long-term disability. The aim of the present work was to assess w… Show more

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Cited by 95 publications
(83 citation statements)
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References 35 publications
(49 reference statements)
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“…Moreover, fractal studies have demonstrated a decrease in fractal dimension of the CNS with illness (i.e., Alzheimer's [42], epilepsy [23,24], MS [45], stroke [49]) which correlates with metabolic studies demonstrating a decline in glucose metabolism with illness [83,85,88,[90][91][92][93][94][95][96][97][101][102][103]. Conversely, there are diseases which demonstrate an increase in fractal dimension including cancer [50][51][52][53][54][55] and grey matter structural changes in MS [46]. Of significance, these diseases which demonstrate an increase in fractal dimension also demonstrate an increase in glucose metabolism.…”
Section: Discussionmentioning
confidence: 99%
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“…Moreover, fractal studies have demonstrated a decrease in fractal dimension of the CNS with illness (i.e., Alzheimer's [42], epilepsy [23,24], MS [45], stroke [49]) which correlates with metabolic studies demonstrating a decline in glucose metabolism with illness [83,85,88,[90][91][92][93][94][95][96][97][101][102][103]. Conversely, there are diseases which demonstrate an increase in fractal dimension including cancer [50][51][52][53][54][55] and grey matter structural changes in MS [46]. Of significance, these diseases which demonstrate an increase in fractal dimension also demonstrate an increase in glucose metabolism.…”
Section: Discussionmentioning
confidence: 99%
“…Compared to normal healthy subjects, patients with MS have been shown to have a significant decrease in white matter fractal dimension in both sections with MS lesions and sections with normal appearing white matter [45]. Conversely, one study of the fractal dimension of grey matter has shown that MS patients have a significant increase in grey matter fractal dimension compared to controls and such differences were apparent even in patients with first attacks of MS and patients with relapsing-remitting MS [46]. The difference in the structural changes in the white matter vs. grey matter suggests that different pathological processes are taking place.…”
Section: Multiple Sclerosismentioning
confidence: 98%
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“…FD analysis can also quantify dynamic changes of the structural or functional complexity of the neural system during the process of brain development or degeneration [10][11][12]. Researchers have also applied FD measurement in many image analyses of central nervous system disorders such as schizophrenia [13], tumor detection [14], multiple sclerosis [15], obsessivecompulsive disorder [16], and age-related WM abnormalities [17].…”
Section: Introductionmentioning
confidence: 99%