Fractal characterizations of MeV ion fractured CaF2 thin films

Pandey, R. K.; Yadav, R. P.; Kumar, Tanuj; Kumar, Ashish; Pathak, Sachin; Awasthi, Shikha; Singh, Udai B.; Pandey, Avinash C.

doi:10.21203/rs.3.rs-2216652/v1

Cited by 2 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, DDRassociated genes have the potential to be actively regulated by many epigenetic mechanisms simultaneously. In spite of the fact that the MGMT promoter DNA is hypermethylated, robust MGMT expression can be enabled by histone acetylation in active enhancer sites [66][67][68][69][70]. As a result, it is possible to envision a scenario in which a patient who possesses a methylated gene associated with drug resistance may look as if they are a candidate who could benefit from therapy with a DNMT inhibitor; however, this may fail due to the fact that histone modification has a greater effect on expression.…”

Section: Challenges and Future Prospectivesmentioning

confidence: 99%

Herbal used as Epigenetic for Cancer Treatment

Navadiya¹,

Goti²,

Raloliya³

et al. 2023

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

Patterns of chromatin accessibility, which are in turn altered by epigenetic mechanisms, are responsible for determining the interactions that take place between transcription machinery, genes, and the cis-regulatory elements of those genes. Mutations that interfere with epigenetic processes frequently have the unfortunate side effect of causing cancer. Since these mutations can be undone, numerous anticancer treatments that target epigenetic pathways are now being developed and evaluated. (Cancer) is becoming more and more common everywhere. This decline in clinical outcomes is a result of a number of factors, including late diagnosis, a lack of efficient treatments for particular cancer subtypes, and drug resistance. Treatment resistance and stemness traits have been recognised as markers of this disease, and it has been demonstrated that epigenetic changes play a role in the process of cancer growth. Understanding these alterations and how they impact cancer carcinogenesis treatment is challenging but crucial. However, it may be able to provide the special knowledge needed to use these alterations as potential diagnostic, prognostic, therapeutic agents, and predictors of treatment efficacy. This underlines the importance of continued research to advance our knowledge of cancer carcinogenesis and epigenetics and help us overcome these challenges. This review aims to provide an overview of the state of the art in epigenetics research for cancer detection and treatment and to stimulate discussion on this subject.

show abstract

Section: Challenges and Future Prospectivesmentioning

confidence: 99%

Herbal used as Epigenetic for Cancer Treatment

Navadiya¹,

Goti²,

Raloliya³

et al. 2023

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…When diabetes is present, oxidative stress can arise in a number of different types of retinal cells or it can have its effects felt by other types of retinal cells too. There are a number of retinal illnesses that involve oxidative stress in their aetiology [11,12,13]. Some of these diseases include retinitis pigmentosa, age-related macular degeneration, retinopathy of prematurity, and diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Amjad,

Gupta,

Anamika

et al. 2024

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

Researchers have been assuming about the possible connection between the eye and the central nervous system (CNS) for a considerable amount of time. This is primarily due to the fact that the eye is considered to be an extension of the brain, which is a reasonable assumption. The neural tube is the beginning of both structures, and neurons are the building blocks of both structures. Retinal ganglionic cells, also known as RGCs, are a specific type of cell that are found in the retina. These cells are responsible for receiving light signals from the environment around them and then transmitting them to photoreceptors, which are involved in the process of vision. The retina, which is found inside the eye, is responsible for converting light into electrical impulses, which are then sent to the brain through the optic nerve. Glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are only few of the eye illnesses that can be caused by chronic progressive neurodegeneration of the retina, which is more prevalent in older people. It is the elderly who are most likely to be affected by these eye disorders; nevertheless, younger people are also susceptible to them and may experience permanent vision loss or a reduction in their eyesight. In most cases, neurodegenerative disorders that are characteristic of CSN are characterised by common symptoms and a cause that is only partially understood. Although certain risk factors have been identified, they do not account for all instances. On the other hand, according to a number of studies, several illnesses of the central nervous system (CNS), such as Alzheimer's disease (AD) and Parkinson's disease (PD), which are responsible for a significant amount of mortality and morbidity on a global scale, display distinctive alterations at the ocular level. It is helpful to be aware of potential linkages in order to have a better understanding of the mechanics on which onset occurs. In addition, experts have not yet reached a consensus regarding the factors that are responsible for these various disorders. In this overview, the symptoms of ocular illnesses are discussed in detail, with a particular focus on the interaction between the brain and the eye. At some point in the future, a more in-depth understanding could be of assistance in the development of innovative treatments that could help reduce or prevent blindness and improve quality of life.

show abstract

Fractal characterizations of MeV ion fractured CaF2 thin films

Cited by 2 publications

References 26 publications

Herbal used as Epigenetic for Cancer Treatment

Herbal used as Epigenetic for Cancer Treatment

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Contact Info

Product

Resources

About