Fractal analysis of mucosal microvascular patterns in oral lichen planus: a preliminary study

Lucchese, Alberta; Gentile, Enrica; Capone, Giovanni; Vico, Gionata De; Serpico, Rosario; Landini, Gabriel

doi:10.1016/j.oooo.2015.06.029

Cited by 12 publications

(17 citation statements)

References 52 publications

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“…Here, the most characteristic RCM signs of malignancies detected were cytological and architectural disarray, mainly expressed by the finding of keratin pearls in well‐differentiated OSCCs; cellular pleomorphism, increased nuclear‐cytoplasmic ratios, and multi‐nucleolated keratinocytes plus rod nucleoli occurring at the suprabasal layers in moderately/poorly‐differentiated OSCC. Finally, the vascular patterns depicted agreed with those reported by Lucchese et al . and Contaldo et al .…”

Section: Discussionsupporting

confidence: 90%

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

et al. 2019

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Background Oral squamous cell carcinoma (OSCC) accounts for more than 90% of oral epithelial malignancies and often arises from precursor lesions, whose diagnosis is based on biopsy and histopathology. In vivo reflectance confocal microscopy (RCM) images the vital tissues at microscopic resolution, well correlating with conventional histopathology, but it is poorly investigated in oral oncology. The present work aims to describe RCM cytoarchitectural findings in oral mucosae affected by OSCC and its precursors. Materials and Methods A series of clinically suspected oral lesions underwent RCM imaging before conventional biopsy and histopathological assessment in order to identify features suggestive of tumoral changes. Sensitivity (SE), specificity (SP), positive and negative predictive values (PPV and NPV) of RCM compared to histopathology were calculated. Results Totally, 30 sites in 20 patients were considered and clinically classified into 16 “leukoplakia”/“ traumatism”, nine erosive‐ulcerative lesions, three verrucous lesions, and two healthy mucosae, as control. The histopathological “positivity,” due to the presence of various degrees of dysplasia and/or neoplasia, was found in 11 lesions; the RCM “positivity” was referred to nine lesions reporting the RCM detection of polymorphism, multinucleated cells, irregular cellular maturation, altered nuclear/cytoplasm ratio, and abnormal blood vessels. After excluding three verrucous lesions from the RCM analysis, due to the low laser penetration through the hyperkeratotic layers, the results well correlated with histopathology, reporting 1.000 (SE), 0.933 (SP), 0.909 (PPV), and 1.000 (NPV). Conclusion RCM can reveal dysplastic/neoplastic signs occurring in oral lesions, thus supporting their diagnostic pathway.

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Section: Discussionsupporting

confidence: 90%

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

et al. 2019

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“…Lucchese et al showed that the FD of LP microvascular pattern is higher in buccal mucosa (1.167) and in the tongue mucosa (1.196) in comparison to healthy mucosa (1.123). 15 No statistical differences were found in our study between the FDs of leukoplakia and LP. However, statistical differences within the groups were observed.…”

Section: Discussioncontrasting

confidence: 65%

Application of fractal dimension analysis and photodynamic diagnosis in the case of differentiation between lichen planus and leukoplakia: A preliminary study

Jurczyszyn¹,

Kazubowska²,

Kubasiewicz−Ross³

et al. 2018

Adv Clin Exp Med

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“…OCTA scans permit to construct a map of blood flow . Considering the central role of vascular architecture in autoimmune disorders and chronic inflammation, the OCTA could prove very encouraging in the study of these diseases in the oral cavity. Although PS‐OCT has been applied to various preclinical and clinical studies and OCTA has been shown to be a useful imaging modality for the evaluation of common ophthalmologic diseases, they have not been used much in the oral cavity …”

Section: Discussionmentioning

confidence: 99%

The potential role of in vivo optical coherence tomography for evaluating oral soft tissue: A systematic review

Gentile

Maio

Romano

et al. 2017

J Oral Pathology Medicine

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Fractal analysis of mucosal microvascular patterns in oral lichen planus: a preliminary study

Abstract: The objective of this study was to assess local vascular architecture in atrophic-erosive oral lichen planus (OLP)

Cited by 12 publications

References 52 publications

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

Application of fractal dimension analysis and photodynamic diagnosis in the case of differentiation between lichen planus and leukoplakia: A preliminary study

The potential role of in vivo optical coherence tomography for evaluating oral soft tissue: A systematic review

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