FRAC Mode of Action Classification and Resistance Risk of Fungicides

Kück, Karl‐Heinz; Leadbeater, Andy; Gisi, U.

doi:10.1002/9783527644179.ch14

Cited by 37 publications

(44 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In particular, the development of resistance to glyphosate in a number of key weed species has been a wake‐up call catalyzing a renewed interest in new herbicides, especially the search for new modes of action (MoAs). Likewise, resistance to fungicides such as the benzimidazoles and strobilurins has had a major impact on the fungicide market and agrochemical discovery . Thus resistance to agrochemicals is an ongoing driver for the development of new chemical control options, along with an increased emphasis on resistance management and how these new tools can fit into resistance management programs .…”

Section: Factors Shaping Agrochemical Discoverymentioning

confidence: 99%

“…Because resistance is such a key driver for the development of new agrochemicals, a highly prized attribute for a new agrochemical is a new MoA that is ideally a new molecular target either in an existing target site (e.g., an unexploited binding site in the voltage‐gated sodium channel), or new/under‐utilized target site such as calcium channels. As such, these new MoAs are distinct from existing target sites facilitating a number of resistance management schemes, especially those based on rotation of MoAs …”

Section: Factors Shaping Agrochemical Discoverymentioning

confidence: 99%

See 1 more Smart Citation

Perspectives on the agrochemical industry and agrochemical discovery

Sparks¹,

Lorsbach²

2016

Pest Management Science

197

184

View full text Add to dashboard Cite

Agrochemicals have been critical to the production of food and fiber, as well as the control of vectors of disease. The need for the discovery and development of new agrochemicals continues unabated due to the loss of existing products through the development of resistance, the desire for products with more favorable environmental and toxicological profiles, shifting pest spectra, and changing agricultural needs and practices. As presented in the associated analysis of the agrochemical industry, the rising costs and complexities of agrochemical discovery have, in part, led to increasing consolidation, especially in the USA and Europe. However, as demonstrated by the present analysis, the discovery of new agrochemicals continues in spite of the challenges. © 2016 Society of Chemical Industry.

show abstract

Section: Factors Shaping Agrochemical Discoverymentioning

confidence: 99%

Section: Factors Shaping Agrochemical Discoverymentioning

confidence: 99%

Perspectives on the agrochemical industry and agrochemical discovery

Sparks¹,

Lorsbach²

2016

Pest Management Science

197

184

View full text Add to dashboard Cite

show abstract

“…Table shows the different classes of fungicides, all based on the FRAC mode of action classification . Perhaps, in comparison with insecticides (see below), the fungicides arguably have been less influenced by NPs.…”

Section: Fungicidesmentioning

confidence: 99%

“…As such, there is a critical need for new tools to control an array of insects, weeds and diseases that reduce the yield of crops the world depends on for food. Compounding the problem is that many of the most important fungal, weed and insect pest species have developed resistance to a majority of the currently available agrochemical tools used for their control . Thus, there is a continuing need for the development of new agrochemical products to provide growers with tools needed to address pest control problems.…”

Section: Introductionmentioning

confidence: 99%

Natural products for pest control: an analysis of their role, value and future

Gerwick¹,

Sparks²

2014

Pest Management Science

244

225

View full text Add to dashboard Cite

Natural products (NPs) have long been used as pesticides and have broadly served as a source of inspiration for a great many commercial synthetic organic fungicides, herbicides and insecticides that are in the market today. In light of the continuing need for new tools to address an ever-changing array of fungal, weed and insect pests, NPs continue to be a source of models and templates for the development of new pest control agents. Interestingly, an examination of the literature suggests that NP models exist for many of the pest control agents that were discovered by other means, suggesting that, had circumstances been different, these NPs could have served as inspiration for the discovery of a great many more of today's pest control agents. Here, an attempt is made to answer questions regarding the existence of an NP model for existing classes of pesticides and what is needed for the discovery of new NPs and NP models for pest control agents.

show abstract

“…Modern agriculture is highly dependent on the use of synthetic chemicals, such as fertilizers and pesticides, including insecticides, herbicides, and fungicides, which are used worldwide to increase crop yield . However, the repeated use of substances that act by the same mechanism of action continuously leads to the development of resistance in several organisms, such as insects, fungi, and weeds, representing a major issue in crop protection . Thus, there is a continuous need for the development of new agrochemicals to provide farmers with effective tools to control pests .…”

Section: Introductionmentioning

confidence: 99%

Amino‐substituted para‐Benzoquinones as Potential Herbicides

Nain-Pérez

Barbosa

Picanço

et al. 2016

Chemistry & Biodiversity

View full text Add to dashboard Cite

Although quinones present a large array of biological activities, a few studies on the herbicidal potential of 2,5-bis(alkyl/arylamino)-1,4-benzoquinones have been reported to date. In this work, starting from benzoquinone, 13 2,5-bis(alkyl/arylamino)-1,4-benzoquinones were prepared in 46 - 93% yield. The products were fully characterized by spectroscopic analyses and their phytotoxicity against Cucumis sativus and Sorghum bicolor seedlings was investigated. At 100 ppm, compounds caused 10 - 88% growth inhibition of the dicotyledonous species, whereas the monocotyledon was less affected. Most compounds exerted little inhibitory effect on a cyanobacterial model strain. However, at 100 μm, compounds 8 - 10 caused about 50% inhibition of algal growth, and compounds 1 and 2 reduced cell viability in the 1 - 10 μm range. The ability of benzoquinone derivatives to interfere with the light-driven ferricyanide reduction by isolated spinach chloroplasts was evaluated. Some substances showed a moderate effect as uncouplers, but no relationship was found between this property and their biological activity, indicating that the herbicidal effect is not associated with the inhibition of the photosynthetic electron transport chain. Phytotoxic compounds were not toxic to insects, strengthening the possibility that they may serve as lead for the development of eco-friendly herbicides.

show abstract

FRAC Mode of Action Classification and Resistance Risk of Fungicides

Cited by 37 publications

References 6 publications

Perspectives on the agrochemical industry and agrochemical discovery

Perspectives on the agrochemical industry and agrochemical discovery

Natural products for pest control: an analysis of their role, value and future

Amino‐substituted para‐Benzoquinones as Potential Herbicides

Contact Info

Product

Resources

About