Fr�h- und Sp�tbefunde nach Biobond-Beschichtung von Intrakraniellen Aneurysmen

Abstract

Fifteen patients with intracranial aneurysms have been treated by coating the aneurysms with Biobond. Three patients died in the postoperative period. Only one patient had recurrent haemorrhage one year after operation. In this case the sac had not been wrapped completely at operation. Histological examination of this aneurysm revealed macrophage reaction and signs of slow disappearance of the plastic. Ten patients, who were followed up for a period of 3 to 8 years after operation, had no recurrent haemorrhage and were in good clinical condition, 8 of them doing full-time work. No complications caused by the material have been encountered. In 5 patients carotid angiography was performed after operation. In 2 cases the size of the aneurysm was diminished and in 3 cases was unchanged. There were no signs of thrombosis or narrowing of the adjacent arteries. We believe that Biobond is suitable for coating intracranial aneurysms that cannot be treated by clipping or ligature. As Biobond in vivo seems partially to disappear after long periods, it should be applied in thick layers.

Coating of intracranial aneurysms: A long-term follow-up study of 34 cases

“…Several synthetic polymers were studied and used for clinical application, but later abandoned: polymethyl methacrylate [5,10,11], Selverstone plastic [23], Biobond, or EDH-adhesive [24]. The group of the cyanoacrylates proved more successful.…”