FPRL1 Receptor Agonist Peptides Prevent Etoposide-Induced Alopecia in Neonatal Rats

Tsuruki, Takahiro; Ito, Ayaka; Takaha, Kyoya; Yoshikawa, Masaaki

doi:10.1111/j.0022-202x.2004.22714.x

Cited by 8 publications

(8 citation statements)

References 7 publications

(7 reference statements)

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“…4). Pyrilamine itself did not induce alopecia (8). These results suggest that GLF prevents etoposide-induced y To whom correspondence should be addressed.…”

mentioning

confidence: 81%

“…7) We found that histamine H 1 receptor antagonist pyrilamine inhibited the anti-alopecia effects of intraperitoneally injected fMLP, suggesting that histamine is involved in the anti-alopecia effects. 8) In this study, we tested the effect of Gly-Leu-Phe (GLF) on etoposide-induced alopecia in neonatal rats to investigate whether the immunostimulating peptide acting through a receptor other than fMLP exhibits an anti-alopecia effect. Originally, GLF was reported to be derived from human casein and to potentiate phagocytosis of human or murine phagocytic cells, [9][10][11] but in fact it is derived from human or bovine -lactalbumin.…”

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confidence: 99%

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Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from α-Lactalbumin

Tsuruki¹,

Yoshikawa²

2005

Bioscience, Biotechnology, and Biochemistry

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Gly-Leu-Phe (GLF), an immunostimulating peptide derived from -lactalbumin, prevented alopecia induced by an anticancer agent etoposide in a neonatal rat model after intraperitoneal injection at a dose of 100 mg/kg for 4 d or oral administration at a dose of 300 mg/kg for 6 d. By microscopic analysis of skin sections, GLF proved to inhibit etoposide-induced loss of hair, thickening of the epidermis, and thinning of the adipocyte layer. The antialopecia effect of GLF was inhibited by pyrilamine, a histamine H 1 receptor antagonist, suggesting that the anti-alopecia effect is mediated by histamine release.

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“…4). Pyrilamine itself did not induce alopecia (8). These results suggest that GLF prevents etoposide-induced y To whom correspondence should be addressed.…”

mentioning

confidence: 81%

mentioning

confidence: 99%

Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from α-Lactalbumin

Tsuruki¹,

Yoshikawa²

2005

Bioscience, Biotechnology, and Biochemistry

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“…Casoxin D (YVPFPPF) was isolated from the pepsin-chymotrypsin digest of human casein as a peptide showing anti-opioid activity in a field-stimulated guinea pig ileum preparation to counteract with -casomorphin [18]. Casoxin D sequence corresponds to the human sl-casein (143)(144)(145)(146)(147)(148)(149). In the absence of field stimulation, Casoxin D is an ileum contracting activity.…”

Section: S1-caseinmentioning

confidence: 99%

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

Yoshikawa

2015

Peptides

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We have found various bioactive peptides derived from animal and plant proteins, which interact with receptors for endogenous bioactive peptides such as opioids, neurotensin, complements C3a and C5a, oxytocin, and formyl peptides etc. Among them, rubiscolin, a δ opioid peptide derived from plant RuBisCO, showed memory-consolidating, anxiolytic-like, and food intake-modulating effects. Soymorphin, a μ opioid peptide derived from β-conglycinin showed anxiolytic-like, anorexigenic, hypoglycemic, and hypotriglyceridemic effects. β-Lactotensin derived from β-lactoglobulin, the first natural ligand for the NTS2 receptor, showed memory-consolidating, anxiolytic-like, and hypocholesterolemic effects. Weak agonist peptides for the complements C3a and C5a receptors were released from many proteins and exerted various central effects. Peptides showing anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were also obtained. Based on these study, new functions and post-receptor mechanisms of receptor commom to endogenous and exogenous bioactive peptides have been clarified.

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“…Rat 8,9 and mouse 7,10 models have been developed to study the histopathologic progression of hair follicle dystrophy 11 after systemic chemotherapy or irradiation of rodents and to test the efficacy of topical or systemic therapies to prevent or suppress alopecia. [12][13][14] A systemic chemotherapy insult to neonatal 10-day-old rat pups, when they are growing their coat at maximum rate, leads to complete alopecia by day 20. 8,9 In adult rats or mice, clipping the coats generally results in synchronized anagen induction, and after systemic chemotherapy, alopecia develops in the clipped area only.…”

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confidence: 99%

A new strategy to prevent chemotherapy and radiotherapy-induced alopecia using topically applied vasoconstrictor

Soref

Fahl

2014

Int. J. Cancer

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In a new strategy, we sought to determine whether topically applied vasoconstrictor, with its accompanying transient skin hypoxia and exclusion of systemic drug, would prevent or suppress radiotherapy or chemotherapy-induced alopecia. Topical vasoconstrictor was applied to 1-cm2 skin patches on the backs of 10-day-old rats and minutes later they received either 7.1 gray (Gy) whole-body radiation or systemic N-nitroso-N-methylurea (MNU) or Cytoxan. The degree of alopecia was scored 10 days later by visual assessment (% coat retention) and hair follicle histologic analysis. Topical application of epinephrine or norepinephrine in an alcohol:water delivery vehicle induced clear skin blanch, and in a dose-dependent manner, topical epinephrine or norepinephrine (20–1,000 mM) applied before 7.1 Gy irradiation conferred 95% of coat retention in the treated skin patches versus 0% coat retention in vehicle controls, or in skin outside the treated patches. By histology, small numbers of dystrophic hair follicles were observed in hairless skin versus the normal density of anagen follicles in the immediately adjacent, drug-protected skin patches at day 20; protected coats were retained into adulthood. Topical epinephrine or norepinephrine before systemic MNU (30 ug/gm body weight) conferred up to 95% of coat retention in treated skin patches versus 0% coat retention elsewhere. Epinephrine-conferred % coat retention dropped to 16% in rats that received systemic Cytoxan, a drug whose plasma half-life is at least 8- to 10-fold longer than MNU. A general strategy is discussed for the use of topical epinephrine or norepinephrine in the clinic to provide an inexpensive and convenient strategy to prevent cancer therapy-induced alopecia.

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FPRL1 Receptor Agonist Peptides Prevent Etoposide-Induced Alopecia in Neonatal Rats

Cited by 8 publications

References 7 publications

Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from α-Lactalbumin

Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from α-Lactalbumin

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

A new strategy to prevent chemotherapy and radiotherapy-induced alopecia using topically applied vasoconstrictor

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