Fp575uric Acid Induces Intraperitoneal Inflammation in Peritoneal Dialysis Patients

Stepanova, N.; Burdeyna, Olena; Driianska, V.; Snisar, L.

doi:10.1093/ndt/gfz106.fp575

Cited by 2 publications

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“…Considering the fact that peritoneal clearance dominates in SUA balance and peritonitis is a significant risk factor for structural and functional alterations in the peritoneal membrane in PD patients, an increased risk of RD decline might be observed in patients with hyperuricemia [23,24]. Second, it has been postulated that a high SUA level induces systemic and intraperitoneal inflammation [15,18,25]. In turn, chronic inflammation is also associated with low RRF [4,19,26].…”

Section: Discussionmentioning

confidence: 99%

Hyperuricemia Predicts Residual Diuresis Decline in Peritoneal Dialysis Patients

2020

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Introduction. The effect of serum uric acid (SUA) concentration on residual urine volume in peritoneal dialysis (PD) patients has not been postulated yet. The present study aimed to investigate the effect of SUA concentration on residual diuresis in PD patients. Methods. It was a retrospective observational study involving 175 patients who were treated with PD for at least 3 months. The primary study outcome was residual dieresis decline<100 mL/24h represented as the time to onset of anuria. Results. A total of 175 PD patients with the median PD vintage of 13.5 [5.0-19.7] months before the enrollment were included in the study. Among the participants, there were 79 (45.2%) men and 96 (54.8%) women. Hyperuricemia was found in 48/79 (60.8%) men and 39/96 (40.6%) women (p=0.008). Residual renal function was significantly lower in the PD patients with hyperuricemia compared with the hyperuricemia-free patients. During a 22.5 [15.8-28.3] month follow-up period, 64 (42.3%) PD patients progressed to anuria and its prevalence was significantly higher in the hyperuricemic group compared with the normouricemic group (64.3% vs 20.4%, p <0.001). The multivariate logistic regression analysis demonstrated that hyperuricemia was an independent risk factor associated with the development of anuria in PD patients. The additional Cox regression analysis confirmed hyperuricemia as a predictor for anuria development in the PD patients: HR 2.6 (95% CI 1.38; 4.9), p=0.003. Conclusions. Hyperuricemia is an independent risk factor for residual diuresis decline < 100 mL/24h in PD patients.

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Section: Discussionmentioning

confidence: 99%

Hyperuricemia Predicts Residual Diuresis Decline in Peritoneal Dialysis Patients

2020

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“…From one point of view, proteinuria is an established risk factor for CKD progression (14,17) and, consequently, can lead to an increase in SUA concentration. Alternatively, accumulating evidence suggests that increased SUA might be a cause for induced oxidative stress, endothelial dysfunction, an increase in inflammatory responses and the formation of proteinuria (18)(19)(20). Furthermore, both glomerular proteinuria (20) and hyperuricemia (10) are the risk factors for glomerulosclerosis, tubular and interstitial damage.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid and renal survival prognosis in primary glomerulonephritis patients in a retrospective single-center cohort

et al. 2020

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Introduction: The role of serum uric acid (SUA) concentration in primary glomerulonephritis (PGN) aggravation is currently under active discussion. Objectives: This study primarily aimed to analyze the association between SUA concentration and renal survival prognosis in PGN patients and secondarily to determine whether hyperuricemia is an independent risk factor for reduced glomerular filtration rate (GFR) in the presence of nephrotic syndrome. Patients and Methods: We performed a retrospective observational single-center study involving 344 patients with biopsy-proved or clinically diagnosed PGN with the mean follow-up period of 5.3 [3.8-6.2] years. The rate of annual decline in estimated GFR (eGFR) was used to assess chronic kidney disease progression. Primary outcome measures were eGFR decline or transfer to renal replacement therapy (RRT) during the 5-year follow-up period. Results: There were 78/344 (22.7%) patients who eventually progressed to eGFR <15 mL/min/1.73 m2 or started RRT. In multivariate logistic regression analysis eGFR at diagnosis, proteinuria and hyperuricemia were associated with increased renal risk in PGN patients during the 5-year follow-up period. However, a less significant effect of SUA on rapid eGFR decline was found in the patients with nephrotic-range proteinuria compared with the patients with mild proteinuria. Conclusion: Our study revealed that a higher level of SUA was significantly associated with a greater annual decline in GFR and, consequently, a worse 5-year renal survival prognosis in PGN patients. The effect of hyperuricemia on the risk of rapid CKD progression was greater in PGN patients with mild proteinuria compared with the patients with nephrotic-range proteinuria.

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Fp575uric Acid Induces Intraperitoneal Inflammation in Peritoneal Dialysis Patients

Cited by 2 publications

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Hyperuricemia Predicts Residual Diuresis Decline in Peritoneal Dialysis Patients

Hyperuricemia Predicts Residual Diuresis Decline in Peritoneal Dialysis Patients

Serum uric acid and renal survival prognosis in primary glomerulonephritis patients in a retrospective single-center cohort

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