FOXQ1 inhibits the progression of osteoarthritis by regulating pyroptosis
Zhihuan Luo,
Hui Zeng,
Kanghua Yang
et al.
Abstract:Background: Osteoarthritis (OA) is the most common age-related joint disease, and the NLRP3-induced pyroptosis has been demonstrated in its progression. The upstream molecules or specific mechanisms controlling NLRP3 and pyroptosis in OA remain unclear.
Methods: Transcriptome sequencing was performed in the OA mice model, and the expression levels of differentially expressed genes were assessed by qRT-PCR. The cell model was constructed by IL-1β-induced ATDC5 cells. The cell proliferation was examin… Show more
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