Foxp4 is essential in maintenance of purkinje cell dendritic arborization in the mouse cerebellum

Tam, Wing Yip; Leung, Constant; Tong, Kwok Kit; Kwan, Kin Ming

doi:10.1016/j.neuroscience.2010.10.023

Cited by 27 publications

(24 citation statements)

References 33 publications

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“…Foxp2 is also expressed from e11.5 within large subpopulations of non-RC V1 neurons including Ia INs [66] and may therefore control different aspects of their development. Likewise, Foxp4, which is present in Foxp2 + V1 cells, may participate in the regulation of differentiation, migration and axonal growth by cooperating with Foxp2 as recently described [117], [118], [119]. Foxp1 is also detected in subsets of V1 INs [66], [120], suggesting that different combinations of Foxp factors may regulate distinct aspects of V1 development including differentiation and migration as recently suggested [58], [66], [121].…”

Section: Discussionmentioning

confidence: 61%

Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord

et al. 2013

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The spinal cord contains neuronal circuits termed Central Pattern Generators (CPGs) that coordinate rhythmic motor activities. CPG circuits consist of motor neurons and multiple interneuron cell types, many of which are derived from four distinct cardinal classes of ventral interneurons, called V0, V1, V2 and V3. While significant progress has been made on elucidating the molecular and genetic mechanisms that control ventral interneuron differentiation, little is known about their distribution along the antero-posterior axis of the spinal cord and their diversification. Here, we report that V0, V1 and V2 interneurons exhibit distinct organizational patterns at brachial, thoracic and lumbar levels of the developing spinal cord. In addition, we demonstrate that each cardinal class of ventral interneurons can be subdivided into several subsets according to the combinatorial expression of different sets of transcription factors, and that these subsets are differentially distributed along the rostrocaudal axis of the spinal cord. This comprehensive molecular profiling of ventral interneurons provides an important resource for investigating neuronal diversification in the developing spinal cord and for understanding the contribution of specific interneuron subsets on CPG circuits and motor control.

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Section: Discussionmentioning

confidence: 61%

Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord

et al. 2013

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“…Intriguingly, Foxp4 loss disrupts the dendritic arborization of mouse Purkinje cells and their contacts with surrounding cells (Tam et al, 2011). Likewise, Foxp2 knockdown in the zebra finch brain has been reported to reduce spine density in regions associated with song acquisition (Schulz et al, 2010), and can accordingly impede vocal motor learning (Haesler et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS

Rousso

Pearson

Gaber

et al. 2012

Neuron

160

192

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SUMMARY Neuroepithelial attachments at adherens junctions are essential for the self-renewal of neural stem and progenitor cells and the polarized organization of the developing central nervous system. The balance between stem cell maintenance and differentiation depends on the precise assembly and disassembly of these adhesive contacts, but the gene regulatory mechanisms orchestrating this process are not known. Here, we demonstrate that two Forkhead transcription factors, Foxp2 and Foxp4, are progressively expressed upon neural differentiation in the spinal cord. Elevated expression of either Foxp represses the expression of a key component of adherens junctions, N-cadherin, and promotes the detachment of differentiating neurons from the neuroepithelium. Conversely, inactivation of Foxp2 and Foxp4 function in both chick and mouse results in a spectrum of neural tube defects associated with neuroepithelial disorganization and enhanced progenitor maintenance. Together, these data reveal a Foxp-based transcriptional mechanism that regulates the integrity and cytoarchitecture of neuroepithelial progenitors.

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“…For example, Purkinje cell differentiation has been shown to require GCps (Berry and Bradley, 1976;Caddy and Herrup, 1990;Baptista et al, 1994). The regulation of GCp proliferation by PCs is well established (Lewis et al, 2004) and PC-derived signals control aspects of glial differentiation (Fukaya et al, 1999;Tam et al, 2010). In addition, the genetic ablation of glial cells has been shown to affect both PC differentiation and GCp proliferation (Delaney et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum

Yaguchi

Echevarrı́a

et al. 2011

Development

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SUMMARYFibroblast growth factors (FGFs) and regulators of the FGF signalling pathway are expressed in several cell types within the cerebellum throughout its development. Although much is known about the function of this pathway during the establishment of the cerebellar territory during early embryogenesis, the role of this pathway during later developmental stages is still poorly understood. Here, we investigated the function of sprouty genes (Spry1, Spry2 and Spry4), which encode feedback antagonists of FGF signalling, during cerebellar development in the mouse. Simultaneous deletion of more than one of these genes resulted in a number of defects, including mediolateral expansion of the cerebellar vermis, reduced thickness of the granule cell layer and abnormal foliation. Analysis of cerebellar development revealed that the anterior cerebellar neuroepithelium in the early embryonic cerebellum was expanded and that granule cell proliferation during late embryogenesis and early postnatal development was reduced. We show that the granule cell proliferation deficit correlated with reduced sonic hedgehog (SHH) expression and signalling. A reduction in Fgfr1 dosage during development rescued these defects, confirming that the abnormalities are due to excess FGF signalling. Our data indicate that sprouty acts both cell autonomously in granule cell precursors and non-cell autonomously to regulate granule cell number. Taken together, our data demonstrate that FGF signalling levels have to be tightly controlled throughout cerebellar development in order to maintain the normal development of multiple cell types.

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Foxp4 is essential in maintenance of purkinje cell dendritic arborization in the mouse cerebellum

Cited by 27 publications

References 33 publications

Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord

Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord

Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS

Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum

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