FOXP3+ T regulatory cells in idiopathic inflammatory myopathies

Waschbisch, Anne; Schwab, Nicholas; Ruck, Tobias; Stenner, Max-Philipp; Wiendl, Heinz

doi:10.1016/j.jneuroim.2010.03.013

Cited by 55 publications

(49 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Foxp3+ T regulatory cells have been detected in patients with DM, PM and IBM and their numbers have been found to inversely correlate with the severity of disease activity [115]. The number of circulating Tregs in patients with IBM and DM has been documented to be lower than in healthy controls [116,117].…”

Section: Induction Of Regulatory T Cellsmentioning

confidence: 99%

The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications

Moran

Mastaglia

2014

Neuromuscular Disorders

View full text Add to dashboard Cite

The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications. Neuromuscular Disorders, 24 (11) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Induction Of Regulatory T Cellsmentioning

confidence: 99%

The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications

Moran

Mastaglia

2014

Neuromuscular Disorders

View full text Add to dashboard Cite

show abstract

“…The amount of Tregs positively correlated with the amount of total CD3 + cells. However, these results are not specific for IBM but could be obtained in PM and DM muscle as well 121. A more recent report shows a significant decrease in circulating Tregs in IBM patients compared to nonmyositic controls 82.…”

Section: Pathomechanisms In Ibmmentioning

confidence: 78%

“…Coadministration of functional Tregs fully protects animals from developing myositis 120. Furthermore, the capacity of Tregs to dampen CD8 + T cell cytotoxicity directed against human myoblasts has been confirmed in vitro121 and immunohistochemical studies in IBM muscle revealed presence of Tregs in close spatial association to other infiltrating mononuclear cells. The amount of Tregs positively correlated with the amount of total CD3 + cells.…”

Section: Pathomechanisms In Ibmmentioning

confidence: 84%

Immune and myodegenerative pathomechanisms in inclusion body myositis

Keller

Schmidt

Lünemann

2017

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Inclusion Body Myositis (IBM) is a relatively common acquired inflammatory myopathy in patients above 50 years of age. Pathological hallmarks of IBM are intramyofiber protein inclusions and endomysial inflammation, indicating that both myodegenerative and inflammatory mechanisms contribute to its pathogenesis. Impaired protein degradation by the autophagic machinery, which regulates innate and adaptive immune responses, in skeletal muscle fibers has recently been identified as a potential key pathomechanism in IBM. Immunotherapies, which are successfully used for treating other inflammatory myopathies lack efficacy in IBM and so far no effective treatment is available. Thus, a better understanding of the mechanistic pathways underlying progressive muscle weakness and atrophy in IBM is crucial in identifying novel promising targets for therapeutic intervention. Here, we discuss recent insights into the pathomechanistic network of mutually dependent inflammatory and degenerative events during IBM.

show abstract

“…Nevertheless, FOXP3 + regulatory T-cells (Treg), which main subset is also CD4+ CD25+, were recently to play a role in IIMs. The number of FOXP3 + Tregs in muscle biopsies correlated with the total number of infiltrating T-cells irrespective of the clinicopathologic IM subset, suggesting that Tregs were attracted as part of the overall inflammatory reaction [49]. In vitro tests showed their ''myo-protective'' function against allogeninc cytotoxic CD8+ T-cells.…”

Section: T-cell: Myofiber Interactions In Polymyositismentioning

confidence: 95%

Pathogenic aspects of dermatomyositis, polymyositis and overlap myositis

Gherardi

2011

La Presse Médicale

View full text Add to dashboard Cite

FOXP3+ T regulatory cells in idiopathic inflammatory myopathies

Cited by 55 publications

References 32 publications

The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications

The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications

Immune and myodegenerative pathomechanisms in inclusion body myositis

Pathogenic aspects of dermatomyositis, polymyositis and overlap myositis

Contact Info

Product

Resources

About