FOXP3 rs3761548 gene variant and interleukin-35 serum levels as biomarkers in patients with multiple sclerosis

Kamal, Ahmed A. M.; Hosny, Marwa M.; Elwahab, Ahmed Abd; Kamal, Yasmine; Shehata, Hatem S.; Hassan, Amr

doi:10.1016/j.neurol.2020.07.010

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…Therefore, SNPs within the promoter region of the FOXP3 gene may contribute to the susceptibility to SLE. Numerous studies have indicated that variations in the FOXP3 gene, specifically those found in the regulatory regions, have been linked to various autoimmune conditions, including asthma [ 36 ], type I diabetes (TID) [ 37 ], MS [ 38 ] and rheumatoid arthritis [ 19 ]. It has been observed that several autoimmune disorders may have overlapping genetic factors.…”

Section: Discussionmentioning

confidence: 99%

FOXP3 gene polymorphisms increase the risk of systemic lupus erythematosus in a Han Chinese population

Du,

Zhao,

et al. 2024

Annals of Medicine

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Section: Discussionmentioning

confidence: 99%

FOXP3 gene polymorphisms increase the risk of systemic lupus erythematosus in a Han Chinese population

Du,

Zhao,

et al. 2024

Annals of Medicine

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“…IL-35 levels have been found to be significantly reduced in patients with ulcerative colitis and multiple sclerosis. IL-35 has also been shown to prevent the development of autoimmune diabetes [74][75][76]. This cytokine is highly unconventional given the number and types of receptors it utilizes, as well as the various pathways it induces [72,73].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between TNF-a, IL-35, VEGF and Cutaneous Microvascular Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes

Neubauer-Geryk,

Wielicka,

Myśliwiec

et al. 2023

Biomedicines

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The aim of this study was to analyze the relationship between immunological markers and the dysfunction of cutaneous microcirculation in young patients with type 1 diabetes. The study group consisted of 46 young patients with type 1 diabetes and no associated complications. Microvascular function was assessed with the use of nail fold capillaroscopy before and after implementing post-occlusive reactive hyperemia. This evaluation was then repeated after 12 months. Patients were divided into two subgroups according to their baseline median coverage (defined as the ratio of capillary surface area to surface area of the image area), which was established during the initial exam (coverageBASE). Additionally, the levels of several serum biomarkers, including VEGF, TNF-a and IL-35, were assessed at the time of the initial examination. HbA1c levels obtained at baseline and after a 12-month interval were also obtained. Mean HbA1c levels obtained during the first two years of the course of the disease were also analyzed. Patients with coverageBASE below 16.85% were found to have higher levels of VEGF and TNF-α, as well as higher levels of HbA1c during the first two years following diabetes diagnosis. Our results support the hypothesis that the development of diabetic complications is strongly influenced by metabolic memory and an imbalance of pro- and anti-inflammatory cytokines, regardless of achieving adequate glycemic control.

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“…Besides vitiligo ,FOXP3 rs3761548C< A was found to be associated with other autoimmune disorders like multiple sclerosis 42 , systemic lupus erythematosus 43 , Graves' Disease 44 , acute cellular rejection after liver transplantation 45 46 and idiopathic recurrent miscarriages 47 .…”

Section: Discussionmentioning

confidence: 99%

Association Between Foxp3 (Rs3761548) Promoter Polymorphism With Vitiligo Patients, Their Clinical Data and Response to Phototherapy: A Study From Egypt

Abdel‐Salam

Zohdy²,

Wassefy³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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Background:The rs3761548 polymorphism (3279 C> A) of the FOXP3 gene is associated with several autoimmune disorders. Its role in vitiligo has not been well studied.We sought to investigate whether rs3761548 polymorphism is associated with vitiligo in Egyptian subjects. Methods:Case-control study where genomic DNA was isolated from blood samples of 100 patients and 100 control subjects and genotyping was done by allele-specific primers. Given that FOXP3 is an X-linked marker, data analysis was done for the entire cohort and then stratified based on the gender. Results:The genotype frequencies differed significantly from patients to control subjects showing that AC genotype was significantly higher in the patient group than control subjects (risky genotype ) despite of the protective nature of CC genotype which observed in our study. According to the alleles , the A allele was higher in the patient than in the control group .Insignificant results were reported according to the association between FOXP3 (rs3761548) promoter polymorphism and clinical data of patients and their response to phototherapy.Conclusions: The rs3761548 of FOXP3 gene may be associated with susceptibility to vitiligo because of altered expression.Both the A allele and AC genotype were significantly associated with vitiligo .

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FOXP3 rs3761548 gene variant and interleukin-35 serum levels as biomarkers in patients with multiple sclerosis

Cited by 8 publications

References 36 publications

FOXP3 gene polymorphisms increase the risk of systemic lupus erythematosus in a Han Chinese population

FOXP3 gene polymorphisms increase the risk of systemic lupus erythematosus in a Han Chinese population

The Relationship between TNF-a, IL-35, VEGF and Cutaneous Microvascular Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes

Association Between Foxp3 (Rs3761548) Promoter Polymorphism With Vitiligo Patients, Their Clinical Data and Response to Phototherapy: A Study From Egypt

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