FOXP3+ regulatory T cells are associated with the severity and prognosis of sarcoidosis
Karen C. Patterson,
Wallace T. Miller,
Wayne W. Hancock
et al.
Abstract:RationaleSarcoidosis is an inflammatory granulomatous disease of unknown etiology with predominant lung involvement. Organ involvement and disease severity, as well as the nature of immune alterations, vary among patients leading to a range of clinical phenotypes and outcomes. Our objective was to evaluate the association of disease course and immune responses in pulmonary sarcoidosis.MethodsIn this prospective cohort study of 30 subjects, most of whom were followed for one year, we evaluated 14 inflammatory m… Show more
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