FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation

Cai, Wei; Hu, Mengyan; Li, Chunyi; Wu, Ruizhen; Lu, Danli; Xie, Chichu; Zhang, Wei; Li, Tiemei; Shen, Shishi; Huang, Huipeng; Qiu, Wei; Liu, Quentin; Lu, Yan; Lu, Zhengqi

doi:10.1080/15548627.2022.2116833

Cited by 23 publications

(15 citation statements)

References 31 publications

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“…It has been reported that BM-MSC shift macrophage toward M2 phenotype, [35] which is endowed with prominent phagocytic capability. [36] LC3-associated phagocytosis (LAP), a noncanonical autophagic pathway, is responsible for bacteria killing in macrophages. [17,37] The current study demonstrated that adoptive BM-MSC transfer enhance LAP of macrophages, which is indispensable for the anti-bacterial effect of the treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Murine Models of Acute Cerebral Ischemic Stroke: An ischemic stroke model was induced with transient middle cerebral artery occlusion (tM-CAO) as previously described. [36] In brief, mice were anesthetized with 1.5-2.0% isoflurane under spontaneous breath. A filament was inserted into the external carotid artery (ECA) and was directed to the middle cerebral artery (MCA) through the internal carotid artery (ICA).…”

Section: Osteogenic and Adipogenic Differentiation Of Bone Marrow Mes...mentioning

confidence: 99%

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Bone Marrow Mesenchymal Stem Cell‐Derived Dermcidin‐Containing Migrasomes enhance LC3‐Associated Phagocytosis of Pulmonary Macrophages and Protect against Post‐Stroke Pneumonia

Li,

Su,

et al. 2023

Advanced Science

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Pneumonia is one of the leading causes of death in patients with acute ischemic stroke (AIS). Antibiotics fail to improve prognosis of patientswith post-stroke pneumonia, albeit suppressing infection, due to adverse impacts on the immune system. The current study reports that bone marrow mesenchymal stem cells (BM-MSC) downregulate bacterial load in the lungs of stroke mice models. RNA-sequencing of the lung from BM-MSC-treated stroke models indicates that BM-MSC modulates pulmonary macrophage activities after cerebral ischemia. Mechanistically, BM-MSC promotes the bacterial phagocytosis of pulmonary macrophages through releasing migrasomes, which are migration-dependent extracellular vesicles. With liquid chromatography-tandem mass spectrometry (LC-MS/MS), the result shows that BM-MSC are found to load the antibacterial peptide dermcidin (DCD) in migrasomes upon bacterial stimulation. Besides the antibiotic effect, DCD enhances LC3-associated phagocytosis (LAP) of macrophages, facilitating their bacterial clearance. The data demonstrate that BM-MSC is a promising therapeutic candidate against post-stroke pneumonia, with dual functions of anti-infection and immunol modulation, which is more than a match for antibiotics treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Osteogenic and Adipogenic Differentiation Of Bone Marrow Mes...mentioning

confidence: 99%

Bone Marrow Mesenchymal Stem Cell‐Derived Dermcidin‐Containing Migrasomes enhance LC3‐Associated Phagocytosis of Pulmonary Macrophages and Protect against Post‐Stroke Pneumonia

Li,

Su,

et al. 2023

Advanced Science

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“…Total protein and mitochondrial proteins of liver tissues are used to assess the effects of ATZ and LYC on mitophagy. Beclin1 acts as an integral scaffold for the PI3K complex and promotes the localization of autophagy-associated proteins to autophagic vesicles . P62 is the first receptor identified as a scavenger of protein polymers and damaged mitochondria.…”

Section: Discussionmentioning

confidence: 99%

“…Beclin1 acts as an integral scaffold for the PI3K complex and promotes the localization of autophagy-associated proteins to autophagic vesicles. 33 P62 is the first receptor identified as a scavenger of protein polymers and damaged mitochondria. The p62 attached to the damaged mitochondria is ubiquitinated and attached to the autophagosome, so the p62 protein and mitochondria are rapidly cleared.…”

Section: Discussionmentioning

confidence: 99%

Holistic Assessment Based On Hepatocyte Mitochondria: Lycopene Repairs Oxidized mtDNA to Alleviate Mitochondrial Stress Induced by Atrazine

Yang,

Wang,

Jian

et al. 2023

J. Agric. Food Chem.

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“…The premise of tissue repair in acute ischemic stroke is the proper termination of cell-death-induced neural inflammation (AIS). Macrophages scavenge cell corpses and produce inflammatory mediators that coordinate immune responses (3).…”

Section: Editorial On the Research Topic Inflammation In Ischemic Str...mentioning

confidence: 99%

Editorial: Inflammation in ischemic stroke and novel therapeutic strategies for stroke treatment

et al. 2022

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FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation

Cited by 23 publications

References 31 publications

Bone Marrow Mesenchymal Stem Cell‐Derived Dermcidin‐Containing Migrasomes enhance LC3‐Associated Phagocytosis of Pulmonary Macrophages and Protect against Post‐Stroke Pneumonia

Bone Marrow Mesenchymal Stem Cell‐Derived Dermcidin‐Containing Migrasomes enhance LC3‐Associated Phagocytosis of Pulmonary Macrophages and Protect against Post‐Stroke Pneumonia

Holistic Assessment Based On Hepatocyte Mitochondria: Lycopene Repairs Oxidized mtDNA to Alleviate Mitochondrial Stress Induced by Atrazine

Editorial: Inflammation in ischemic stroke and novel therapeutic strategies for stroke treatment

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