Foxp3 Expressing Regulatory T-Cells in Allergic Disease

Nouri‐Aria, Kayhan T.

doi:10.1007/978-1-4419-1599-3_14

Cited by 21 publications

(16 citation statements)

References 88 publications

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“…Because Th2 cytokines were markedly increased in the lung in this study, most CD4 + cells increased in the lung by multiple antigen challenges should be CD4 + Th2 cells; however, it is well known that some dendritic cells and iNKT cells are also CD4 + (38,39 (40,41). We have detected antigen-induced Tr1-type IL-10-producing cells in the lung (T. Nabe et al, unpublished data).…”

Section: Effects Of Anti-il-5 Mab On the Development Of Airway Remodementioning

confidence: 53%

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Nabe¹,

Morishita²,

Matsuya³

et al. 2011

J Pharmacol Sci

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Abstract. It is known that the late asthmatic response (LAR), a characteristic feature of asthma, is closely associated with CD4 + Th2 cell-mediated allergic inflammation. Airway remodeling is also a pathogenesis of asthma, but literature reporting roles of CD4 + cells in the remodeling is controversial. There has been no study that simultaneously assessed the roles of CD4 + cells in both LAR and airway remodeling. Sensitized mice were intratracheally challenged with ovalbumin 4 times. Treatment with an anti-CD4 monoclonal antibody (mAb) before the 1st challenge almost completely abolished increase in CD4 + cells in the tissues after the 4th challenge. The late phase increase in airway resistance after the 4th challenge was also completely inhibited by anti-CD4 mAb. Parameters of airway remodeling, subepithelial fibrosis and epithelial thickening were attenuated by treatment, whereas the inhibition was only 30% -40%. Bronchial smooth muscle thickening was not affected. Because interleukin (IL)-5 production as well as eosinophilia was effectively suppressed by anti-CD4 mAb, the effect of anti-IL-5 mAb was also examined, resulting in no inhibition of airway remodeling. Collectively, although the LAR was completely dependent on CD4 + cell activation, airway remodeling was only partially dependent on the cell.

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Section: Effects Of Anti-il-5 Mab On the Development Of Airway Remodementioning

confidence: 53%

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Nabe¹,

Morishita²,

Matsuya³

et al. 2011

J Pharmacol Sci

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“…It is known that T cells play a key regulatory role in T-cell homeostasis and promote a correct immune response [38,39]. It is widely believed that immunological basis of chronic allergic inflammatory according to inappropriate responses of T-cell helper 2 (Th2) to common allergens.…”

Section: Examination Of Correlation Between Vitamin D 3 (25-ohd 3 ) Cmentioning

confidence: 99%

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Kalicki¹,

Lewicki²,

Stankiewicz³

et al. 2013

cejoi

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Populations of T lymphocytes cells called regulatory T lymphocytes (Tregs) play a key role in the formation and maintenance of immune tolerance. This phenotypically heterogeneous group of cells regulates the immune system and plays an important role in tumor immunology, transplant immunology and the pathogenesis of multiple disorders, in particular autoimmune diseases. In the study it was decided to investigate the difference in the correlation of levels of vitamin D 3 (25-OHD 3 ) with the percentage of Tregs cells (FoxP3+) in children with no symptoms of allergy (control group), and with symptoms of allergy. In addition, in both groups the phenotype of lymphocytes was identified. The results indicate a positive correlation between only in children with allergic symptoms (no correlation in the control group), along with a simultaneous significant reduction in the percentage of CD4 lymphocytes in this group.

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“…Moreover, several studies have demonstrated that epigenetic modifications in CpG-rich regions within the FOXP3 locus of Treg are associated with stable Foxp3 expression and Treg suppressive function 25–27,69 . Treg subsets including natural Treg (nTreg, derived from the thymus) and induced Treg (iTreg, derived from the periphery from Teff cells) have been described 28–31 . iTreg can be characterized as CD4+CD25 hi cells that proliferate in response to specific antigens (i.e., CFSE lo or CD40L/CD69+) 32–35 .…”

Section: Introductionmentioning

confidence: 99%

“…iTreg can be Foxp3+ and/or TGF-β+ and/or IL-10+ 32,34,36,37,49,68 . Type 1 regulatory T cells (Tr1) release IL-10 28,38,39 and express CD4, CD49, and LAG3 on their surface 28,38,39 which differs from nTreg expressing CD4, CD25 hi , CD127 lo , and perhaps by Helios on their surface 25–27,40–43 .…”

Section: Introductionmentioning

confidence: 99%

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

Syed

Garcia

Lyu

et al. 2014

Journal of Allergy and Clinical Immunology

406

412

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Background The mechanisms contributing to clinical immune tolerance remain incompletely understood. This study provides evidence for specific immune mechanisms that are associated with a model of operationally defined clinical tolerance. Objective Our overall objective was to study laboratory changes associated with clinical immune tolerance in antigen-induced T cells, basophils, and antibodies in subjects undergoing oral immunotherapy (OIT) for peanut allergy. Methods In a phase 1, single site study, we studied participants (n=23) undergoing peanut OIT and compared them to age-matched allergic controls (n=20) undergoing standard of care (abstaining from peanut) for 24 months. Participants were operationally defined as clinically immune tolerant (IT) if they had no detectable allergic reactions to a peanut oral food challenge after 3 months of therapy withdrawal (IT, n=7) while those that had an allergic reaction were categorized as non-tolerant (NT, n=13). Results Antibody and basophil activation measurements did not statistically differentiate between NT vs. IT. However, T-cell function and demethylation of FOXP3 CpG sites in antigen-induced Treg were significantly different between IT vs. NT participants. When IT participants were withdrawn from peanut therapy for an additional 3 months (total of 6 months); only 3 participants remained "immune tolerant" and 4 participants regained sensitivity along with increased methylation of FOXP3 CpG sites in antigen-induced Treg. Conclusion In summary, modifications at the DNA level of antigen-induced T-cell subsets may be predictive of a state of operationally-defined clinical "immune tolerance" during peanut OIT.

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Foxp3 Expressing Regulatory T-Cells in Allergic Disease

Cited by 21 publications

References 88 publications

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

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