Foxp3 (−/ATT) Polymorphism Contributes to the Susceptibility of Preeclampsia

Abstract

ObjectiveTo evaluate the potential influence of Foxp3 polymorphism on preeclampsia (PE) susceptibility, we conducted a case-control study in Han Chinese women.Methods Foxp3 genotyping was determined by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 156 PE patients and 252 age-frequency matched controls. Immunohistochemical staining was used to detect the expression of Foxp3 specific transcription factor in 30 PE and 30 normal pregnant women.ResultsThe positive rate of Foxp3 expression in PE (26.67%) was significant difference from that in normal control (63.33%, P<0.05). The frequency of Foxp3-6054 TT genotype was significantly lower in PE patient than that in control. No significant difference was found in Foxp3-3279 genotypes between PE and control, as well as for the variant allele. The frequency of Foxp3-6054A/−3279C haplotype in PE was significantly higher than that in control (P<0.01), while the frequency of Foxp3 6054T/−3279C haplotype was significantly lower in PE patient than that in control (P<0.01).ConclusionOur findings suggest that the immune suppression function in PE patients is weakened, which may result in the occurrence of PE. Foxp3 polymorphism (rs5902434) may be a potential contributor for the development of PE in Han Chinese women.

Association between functional polymorphisms of Foxp3 and Interleukin-21 genes with the occurrence of recurrent pregnancy loss in Gaza strip-Palestine

“…31 On the other hand, the two Foxp3 polymorphisms (rs2232365 and rs3761548) proved to be significantly associated with RPL. This result consolidates the findings of Chen et al, (2013) and Wu et al, (2011) who reported significant associations between pre-eclampsia and rs3761548 in Indian women and between the two polymorphisms and unexplained RPL in Chinese women. 32 In the contrary, Abbasirad et al, (2013) Discrepancies between results of genetic association studies like those encountered here could be due to many reasons including population genetic variation (background) unrelated to the investigated alleles, presence of nucleotide polymorphism somewhere else in the examined gene e.g., in the coding/non-coding regions, epigenetic alterations and linkage disequilibrium to other sequence variants in the vicinity of the studied loci.…”

Polymorphism in Regulatory T-cell (Treg)-Related Genes Is Associated with Unexplained Recurrent Pregnancy Loss

“…Indeed, studies have shown that polymorphisms in those genes are associated with various inflammatory and autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis and SLE, that may also predispose to RPL [3,8,9,[18][19][20][21]. However, very limited studies, and for NKG7 no previous studies, have investigated the direct relation between those five polymorphisms and unexplained RPL.…”

Genetic variants and expression study of FOXP3 gene in acute coronary syndrome in Iranian patients

“…Accordingly, studies in autoimmunity should be stratified based on gender . In addition, the role of FOXP3 variants has been evaluated in many female immune‐related disorders such as unexplained recurrent spontaneous abortion and preeclampsia . Furthermore, there are few reports indicating the protective role of some FOXP3 variants against autoimmune disorders such as vitiligo or allergic rhinitis in only female patients or a more pronounced effect of some variants in male patients, which implies a distinct sex‐related pathogenesis for such disorders.…”