FOXK2 Transcription Factor and Its Emerging Roles in Cancer

Moraes, Gabriela Nestal de; Carneiro, Luciana da Torre; Maia, Raquel Ciuvalschi; Lam, Eric W.‐F.; Sharrocks, Andrew D.

doi:10.3390/cancers11030393

Cited by 44 publications

(34 citation statements)

References 58 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Foxk proteins promote the expression of genes encoding components from the glycolytic pathway and hence contribute to metabolic reprogramming ( 15 , 16 ). There is a growing appreciation of the biological importance of the FOXK proteins and their deregulation in diseases such as cancer (reviewed in 17 ). Developmentally, FoxK has been implicated in TGF-β signalling during midgut differentiation in Drosophila ( 18 ) and also has a role in stem cell biology as the mouse homologue of FOXK1, MNF, controls the proliferation of myogenic stem cells ( 8 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation

Liu

et al. 2021

Nucleic Acids Research

View full text Add to dashboard Cite

Enhancers play important roles in controlling gene expression in a choreographed spatial and temporal manner during development. However, it is unclear how these regulatory regions are established during differentiation. Here we investigated the genome-wide binding profile of the forkhead transcription factor FOXK2 in human embryonic stem cells (ESCs) and downstream cell types. This transcription factor is bound to thousands of regulatory regions in human ESCs, and binding at many sites is maintained as cells differentiate to mesendodermal and neural precursor cell (NPC) types, alongside the emergence of new binding regions. FOXK2 binding is generally associated with active histone marks in any given cell type. Furthermore newly acquired, or retained FOXK2 binding regions show elevated levels of activating histone marks following differentiation to NPCs. In keeping with this association with activating marks, we demonstrate a role for FOXK transcription factors in gene activation during NPC differentiation. FOXK2 occupancy in ESCs is therefore an early mark for delineating the regulatory regions, which become activated in later lineages.

show abstract

Section: Introductionmentioning

confidence: 99%

The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation

Liu

et al. 2021

Nucleic Acids Research

View full text Add to dashboard Cite

show abstract

“…Growing evidence shows that FOXK2 participates in a range of key processes in cancer cells, such as cell proliferation, invasion and migration, DNA damage, and autophagy [46]. The function of FOXK2 is context and tumor-speci c, and it might serve as an oncogene and tumor suppressor in different cancers [47]. It was reported that FOXK2 inhibited cell proliferation and invasion in breast cancer, non-small cell lung cancer (NSCLC), clear-cell renal cell carcinoma, gastric cancer, and indicated favorable prognosis [48][49][50][51].…”

Section: Discussionmentioning

confidence: 99%

Development of a novel transcription factors-related prognostic signature for serous ovarian cancer

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundOvarian cancer (OC) is one of the most lethal gynecological cancer globally. Serous ovarian cancer (SOC) is most common pathological type of ovarian cancer. Growing evidence suggests that transcription factors (TFs) play vital roles in serous ovarian cancer (SOC). In the present study, we aimed to develop a transcription factors-related prognostic signature to better predict the survival in patients with SOC.Materials and methodsThe TFs mRNA expression profiles of 564 SOC subjects in the TCGA database, and 70 SOC subjects in the GEO database were screened. Lasso cox regression and consensus clustering analysis were utilized to construct a novel TFs related signature and cluster model, respectively. Genomic alternative analysis was used to elaborate on the association between the TFs related prognostic signature and genomic aberrations. GSEA analysis was applied to identify the biological functional difference between high risk-score group and low-risk score group.ResultsA 17-TFs related prognostic signature was constructed using lasso cox regression and validated in the TCGA and GEO cohorts. Consensus clustering analysis was applied to establish a cluster model. The 17-TFs related prognostic signature, risk score, and cluster models were effective at accurately distinguishing the prognosis of SOC. The GSEA assay results suggested that there was a significant difference in the inflammatory and immune response pathways between the high-risk and low-risk score groups. Immune infiltration, immunotherapy, and chemotherapy responses were analyzed due to the significant difference in the regulation of lymphocyte migration and T cell-mediated cytotoxicity between the two groups; indicating that patients with low-risk score were more likely to respond anti-PD-1, etoposide, paclitaxel, and veliparib but not to gemcitabine, doxorubicin, docetaxel, and cisplatin. Also, the prognostic nomogram model revealed that the risk score was a good prognostic indicator for SOC patients.ConclusionsIn conclusion, we explored the prognostic values of TFs in SOC and developed a 17-TFs related prognostic signature to predict the survival of SOC patients.

show abstract

“…5G). Transcription factor (TF) binding to promoters or enhancers is essential for gene transcription, which can activate or repress the expression of genes in a sequencespeci c manner 6 . To further explore this possibility, several TFs were analysed.…”

Section: Construction and Analysis Of Top2a Co-expression Network Inmentioning

confidence: 99%

Identification of DNA topoisomerase II-alpha as a regulatory target in hepatocellular carcinoma

Chen¹,

Zhao²,

Yang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Although DNA topoisomerase II-alpha (TOP2A) has been reported to be associated with tumour pathological processes, systematic research in hepatocellular carcinoma (HCC) prognosis remains scarce. Therefore, this study aimed to investigate the role of differential TOP2A expression in HCC.Results: Our findings revealed that TOP2A was significantly overexpressed in patients with HCC. Higher TOP2A expression is an independent risk factor for survival and prognosis. Subsequently, GO and KEGG pathway analyses showed TOP2A was mainly enriched in cell cycle, DNA replication, immunity, and metabolic-related pathway. We then conducted an integrated analysis of TOP2A, it showed specific relationship between TOP2A and immune-infiltrating cells in HCC. Furthermore, the latent function of query drugs in HCC was explored by integrating drug‑target, drug‑pathway and drug‑protein interactions.Conclusions: Mechanistically, we suggest that overexpression of TOP2A in patients with liver cancer can trigger an anti-tumour immune response by modulating the effective immune response and lymphocyte infiltration. Our findings suggest that TOP2A may play essential biological roles in HCC progression and represent potentially important candidate target in HCC therapy.

show abstract

FOXK2 Transcription Factor and Its Emerging Roles in Cancer

Cited by 44 publications

References 58 publications

The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation

The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation

Development of a novel transcription factors-related prognostic signature for serous ovarian cancer

Identification of DNA topoisomerase II-alpha as a regulatory target in hepatocellular carcinoma

Contact Info

Product

Resources

About