Foxk1 promotes bone formation through inducing aerobic glycolysis
Songlin Peng,
Chungeng Liu,
Naibo Feng
et al.
Abstract:Transcription factor Foxk1 can regulate cell proliferation, differentiation, metabolism, and promote skeletal muscle regeneration and cardiogenesis. However, the roles of Foxk1 in bone formation is unknown. Here, we showed that the expression of Foxk1 decreased in the bone tissue of aged mice and osteoporosis patients. Knockdown of Foxk1 in primary murine calvarial osteoblastssuppressedosteoblast differentiation and proliferation. Conditional knockout of Foxk1 in preosteoblasts and mature osteoblasts in mice e… Show more
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